Xanthogranuloma of the Iris Simulating Melanoma in an Adult

Somsiri Sukavatcharin; Sylvia Cursino; Gisele Li; Ronald L. Green; Jennifer I. Lim; Narsing A. Rao

doi:10.1016/j.ajo.2006.10.023

Xanthogranuloma of the Iris Simulating Melanoma in an Adult

Somsiri Sukavatcharin
, Sylvia Cursino
, Gisele Li
, Ronald L. Green
, Jennifer I. Lim
, Narsing A. Rao

Keck School of Medicine of USC

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Purpose: To report a case in an adult of xanthogranuloma of the iris that clinically simulated iris melanoma. Design: Observational case report. Methods: Clinical and histopathologic examination of iris mass obtained from a 77-year-old white woman. Results: High-frequency ultrasonography of the right eye revealed a small, echodense lesion involving the iris root. The mass revealed histopathologic features identical to juvenile xanthogranuloma (JXG), including histiocytes and lymphocytes mixed with multinucleated giant cells, and eosinophilic leukocytes. The histiocytes stained positive for CD68, CD45, and factor XIIIa and negative for S-100 and CD1a. Conclusions: Xanthogranuloma of the iris can occur in elderly patients. Such lesions should be considered in the differential diagnosis of iris melanoma.

Original language	English
Pages (from-to)	529-531
Number of pages	3
Journal	American Journal of Ophthalmology
Volume	143
Issue number	3
DOIs	https://doi.org/10.1016/j.ajo.2006.10.023
Publication status	Published - Mar 2007
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.ajo.2006.10.023

Cite this

@article{583b82b638ad45fe8afcd9577911c4eb,

title = "Xanthogranuloma of the Iris Simulating Melanoma in an Adult",

abstract = "Purpose: To report a case in an adult of xanthogranuloma of the iris that clinically simulated iris melanoma. Design: Observational case report. Methods: Clinical and histopathologic examination of iris mass obtained from a 77-year-old white woman. Results: High-frequency ultrasonography of the right eye revealed a small, echodense lesion involving the iris root. The mass revealed histopathologic features identical to juvenile xanthogranuloma (JXG), including histiocytes and lymphocytes mixed with multinucleated giant cells, and eosinophilic leukocytes. The histiocytes stained positive for CD68, CD45, and factor XIIIa and negative for S-100 and CD1a. Conclusions: Xanthogranuloma of the iris can occur in elderly patients. Such lesions should be considered in the differential diagnosis of iris melanoma.",

author = "Somsiri Sukavatcharin and Sylvia Cursino and Gisele Li and Green, \{Ronald L.\} and Lim, \{Jennifer I.\} and Rao, \{Narsing A.\}",

year = "2007",

month = mar,

doi = "10.1016/j.ajo.2006.10.023",

language = "English",

volume = "143",

pages = "529--531",

journal = "American Journal of Ophthalmology",

issn = "0002-9394",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Xanthogranuloma of the Iris Simulating Melanoma in an Adult

AU - Sukavatcharin, Somsiri

AU - Cursino, Sylvia

AU - Li, Gisele

AU - Green, Ronald L.

AU - Lim, Jennifer I.

AU - Rao, Narsing A.

PY - 2007/3

Y1 - 2007/3

N2 - Purpose: To report a case in an adult of xanthogranuloma of the iris that clinically simulated iris melanoma. Design: Observational case report. Methods: Clinical and histopathologic examination of iris mass obtained from a 77-year-old white woman. Results: High-frequency ultrasonography of the right eye revealed a small, echodense lesion involving the iris root. The mass revealed histopathologic features identical to juvenile xanthogranuloma (JXG), including histiocytes and lymphocytes mixed with multinucleated giant cells, and eosinophilic leukocytes. The histiocytes stained positive for CD68, CD45, and factor XIIIa and negative for S-100 and CD1a. Conclusions: Xanthogranuloma of the iris can occur in elderly patients. Such lesions should be considered in the differential diagnosis of iris melanoma.

AB - Purpose: To report a case in an adult of xanthogranuloma of the iris that clinically simulated iris melanoma. Design: Observational case report. Methods: Clinical and histopathologic examination of iris mass obtained from a 77-year-old white woman. Results: High-frequency ultrasonography of the right eye revealed a small, echodense lesion involving the iris root. The mass revealed histopathologic features identical to juvenile xanthogranuloma (JXG), including histiocytes and lymphocytes mixed with multinucleated giant cells, and eosinophilic leukocytes. The histiocytes stained positive for CD68, CD45, and factor XIIIa and negative for S-100 and CD1a. Conclusions: Xanthogranuloma of the iris can occur in elderly patients. Such lesions should be considered in the differential diagnosis of iris melanoma.

UR - https://www.scopus.com/pages/publications/33847022262

U2 - 10.1016/j.ajo.2006.10.023

DO - 10.1016/j.ajo.2006.10.023

M3 - Article

C2 - 17317408

AN - SCOPUS:33847022262

SN - 0002-9394

VL - 143

SP - 529

EP - 531

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

IS - 3

ER -

Xanthogranuloma of the Iris Simulating Melanoma in an Adult

Abstract

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