Wound healing activity of lawsoniainermis linn in rat model

Background: Wound healing is the repairing process following the injury to the skin and soft tissues. Many kinds of wound dressings and agents are used for promoting the wound healing process. Objective: To evaluate the effect of Lawsoniainermis Linn. A herbal extraction, in wound healing process. Material and Method: In the present study Twenty Sprague Dawley rats were equally random into 4 groups. Each group were created similar excisional wound model and received 4 different kinds of wound dressings including Lawsoniainermis Linn., Silver Zinc sulfadiazine and hydrogel. We compared wound size reduction and rate of epithelalization and also studied histological change of the wound. Results: The wound size reduction and rate of epithelialiazation were significantly better in Lawsoniainermis Linn comparing to the other groups. Also, Histological study showed a significant increase in collagen and fibroblasts and decrease inflammatory cells. Conclusion: Lawsoniainermis Linn can promote the process of wound healing in animal model and should be further studied in the future.