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Transport of single molecules through nanochannels: A novel approach to DNA sequencing

  • Rattikan Chantiwas
  • , Mateusz L. Hupert
  • , Jesús Tamarit López
  • , Proyag Datta
  • , Jost Gottert
  • , Brian Novak
  • , Dorel Moldovan
  • , Shantenu Jha
  • , Sunggook Park
  • , Michael C. Murphy
  • , Dimitris E. Nikitopoulos
  • , Steven A. Soper
  • Louisiana State University
  • Universitat Politècnica de València

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Understanding the transport dynamics of single molecules through 1D and 2D nano-channels is a fundamental prerequisite toward designing high-throughput systems for DNA sequencing. Our efforts are focused on the fabrication of the prerequisite structures using replication technology to produce both nano- and micro-scale channels in polymeric substrates with the size of these channels equal to or less than the persistence length of a dsDNA biopolymer. Molecular dynamics is being used to study the transport of DNA mononucleotides through 1D molecular-scale channels for identification.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages177-179
Number of pages3
ISBN (Print)9780979806421
Publication statusPublished - 2009
Externally publishedYes
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: 1 Nov 20095 Nov 2009

Publication series

NameProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
Country/TerritoryKorea, Republic of
CityJeju
Period1/11/095/11/09

Keywords

  • DNA sequencing
  • Nanochannels
  • Single molecules

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