Abstract
The human UDP-glucuronosyltransferase, UGT1A9, catalyzes glucuronidation of various endobiotics and xenobiotics. In this study, we sequenced the promoter and exon 1 regions of the UGT1A9 gene in 93 Thai individuals and identified 7 genetic polymorphisms. The allele frequencies of all 3 novel single nucleotide polymorphisms (SNPs): 454A>G and 455A>C (N152A) and 760C>T (R254X) were 0.005. The other 4 known polymorphisms, -688A>C, 440T>C, 331C>T -118A(T)10AT (UGT1A9*1b), were identified and found to have frequencies of 0.124, 0.978, 0.968 and 0.532, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 482-485 |
| Number of pages | 4 |
| Journal | Drug Metabolism and Pharmacokinetics |
| Volume | 24 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2009 |
| Externally published | Yes |
Keywords
- Nonsynonymous SNP
- Novel SNPs
- Thai
- Udp-glucuronosyltransferase
- Ugt1a9
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