The scent of Mycobacterium tuberculosis - Part II breath

Mona Syhre; Laurens Manning; Suparat Phuanukoonnon; Paul Harino; Stephen T. Chambers

doi:10.1016/j.tube.2009.04.003

The scent of Mycobacterium tuberculosis - Part II breath

Mona Syhre
, Laurens Manning
, Suparat Phuanukoonnon
, Paul Harino
, Stephen T. Chambers

Otago University
Papua New Guinea Institute of Medical Research
University of Western Australia

Research output: Contribution to journal › Article › peer-review

128 Citations (Scopus)

Abstract

Recent figures show that tuberculosis (TB) is advancing and killing more than two million people annually, yet no breakthrough in rapid diagnostics is in sight. Volatile metabolites of Mycobacterium tuberculosis (MTB) may provide just that. It is well established that MTB produces nicotinic acid in vitro. We have converted the free acid into methyl nicotinate and detected statistically significant differences in the breath of smear positive patients compared with healthy (smear negative) subjects.

Original language	English
Pages (from-to)	263-266
Number of pages	4
Journal	Tuberculosis
Volume	89
Issue number	4
DOIs	https://doi.org/10.1016/j.tube.2009.04.003
Publication status	Published - Jul 2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breath
GC/MS-MS
Methyl nicotinate
Mycobacterium tuberculosis
SPME

Access to Document

10.1016/j.tube.2009.04.003

Cite this

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title = "The scent of Mycobacterium tuberculosis - Part II breath",

abstract = "Recent figures show that tuberculosis (TB) is advancing and killing more than two million people annually, yet no breakthrough in rapid diagnostics is in sight. Volatile metabolites of Mycobacterium tuberculosis (MTB) may provide just that. It is well established that MTB produces nicotinic acid in vitro. We have converted the free acid into methyl nicotinate and detected statistically significant differences in the breath of smear positive patients compared with healthy (smear negative) subjects.",

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AU - Syhre, Mona

AU - Manning, Laurens

AU - Phuanukoonnon, Suparat

AU - Harino, Paul

AU - Chambers, Stephen T.

PY - 2009/7

Y1 - 2009/7

N2 - Recent figures show that tuberculosis (TB) is advancing and killing more than two million people annually, yet no breakthrough in rapid diagnostics is in sight. Volatile metabolites of Mycobacterium tuberculosis (MTB) may provide just that. It is well established that MTB produces nicotinic acid in vitro. We have converted the free acid into methyl nicotinate and detected statistically significant differences in the breath of smear positive patients compared with healthy (smear negative) subjects.

AB - Recent figures show that tuberculosis (TB) is advancing and killing more than two million people annually, yet no breakthrough in rapid diagnostics is in sight. Volatile metabolites of Mycobacterium tuberculosis (MTB) may provide just that. It is well established that MTB produces nicotinic acid in vitro. We have converted the free acid into methyl nicotinate and detected statistically significant differences in the breath of smear positive patients compared with healthy (smear negative) subjects.

KW - Breath

KW - GC/MS-MS

KW - Methyl nicotinate

KW - Mycobacterium tuberculosis

KW - SPME

UR - https://www.scopus.com/pages/publications/67650708042

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DO - 10.1016/j.tube.2009.04.003

M3 - Article

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JO - Tuberculosis

JF - Tuberculosis

IS - 4

ER -

The scent of Mycobacterium tuberculosis - Part II breath

Abstract

UN SDGs

Keywords

Access to Document

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