The Incidence of Autosomal Dominant Polycystic Kidney Disease (ADPKD) in Patients with Intracranial Aneurysms

Background: There has been no previous study about the incidence of autosomal dominant polycystic kidney disease (ADPKD) and factors predicting possibility of ADPKD in patients with intracranial aneurysms. Objective: To investigate the incidence of ADPKD in patients with intracranial aneurysms and predictive factor of ADPKD to screen and treat patients and family members who may have hidden abnormal genes of this disease. Material and Method: This is a retrospective study which recruited patients with intracranial aneurysms who underwent abdominal imaging study, including ultrasonography (USG) or computerized tomography (CT). The incidence of ADPKD and factor predicting this disease were investigated. Results: Of 94 patients with intracranial aneurysms, the incidence of ADPKD was 8.5%. Factors predicting ADPKD included high serum creatinine level and male gender. There was no significant difference in age, incidence of hypertension and diabetes mellitus between intracranial aneurysm patients with and without ADPKD. Conclusion: The present authors recommend performing abdominal USG in patients with intracranial aneurysms for screening ADPKD because USG is non-invasive, inexpensive and useful in treatment and prevention of consequence of this disease in patients and family members who may have the abnormal genes.