The impact of multimorbidity on Quality of Life in inflammatory myopathies: A cluster analysis from the COVAD dataset

on behalf of CoVAD Study Group

doi:10.1093/rheumatology/keae520

The impact of multimorbidity on Quality of Life in inflammatory myopathies: A cluster analysis from the COVAD dataset

on behalf of CoVAD Study Group

Department of Medicine

University of Bari “Aldo Moro,” Plastic and Reconstructive Surgery and Burns Unit
University of Milan
BJ Medical College and Sassoon General Hospitals
Taichung Veterans General Hospital
NIHR Leeds Biomedical Research Centre
University of Leeds, School of Medicine
Mymensingh Medical College
University of Illinois College of Medicine
Mahatma Gandhi Mission Medical College
University of São Paulo
Universidade Potiguar
Seth GS Medical College and KEM Hospital
Saint-Joseph University
Hotel-Dieu de France Hospital
Sofia University St. Kliment Ohridski
Green Life Medical College
University Hospital "St. Ivan Rilski"
Pomeranian Medical University in Szczecin
Hospital Sultanah Bahiyah
Instituto Mexicano del Seguro Social
University of Pavia
National Center for Rheumatic Diseases (NCRD)
Nippon Medical School Graduate School of Medicine
National University of Malaysia
Erlangen University Hospital
Mayo Clinic
Instituto Nacional de Enfermedades Respiratorias
King Faisal Specialist Hospital and Research Center
University of Ghana
Pontifica Universidad Javeriana
Queen Savang Vadhana Memorial Hospital
Hospital Universidad Del Norte
University Hospital Zurich
Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Royal Melbourne Hospital
Karolinska Institutet and Karolinska University Hospital
Faculty of Medicine and Health
King's College London
King's College Hospital
Manchester University NHS Foundation Trust
Salford Royal Hospital
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Royal Wolverhampton Hospitals Nhs Trust

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

Objective: The presence of comorbidities can substantially affect patients’ quality of life, but data regarding their impact on idiopathic inflammatory myopathies (IIMs) are limited. Methods: We examined the prevalence of comorbidities in IIM patients, other autoimmune rheumatic diseases (oAIRDs) and healthy controls (HCs), using data from the self-reported COVAD-2 survey. We defined basic multimorbidity (BM) as the presence of ≥2 non-rheumatic chronic conditions and complex multimorbidity (CM) as the presence of ≥3 non-rheumatic chronic conditions affecting ≥3 organ systems. Hierarchical clustering on principal components was performed for grouping. Results: Among the COVAD respondents, 1558 IIMs, 4591 oAIRDs and 3652 HCs were analysed. IIMs exhibited a high burden of comorbidities (odds ratio [OR]: 1.62 vs oAIRDs and 2.95 vs HCs, P<0.01), BM (OR: 1.66 vs oAIRDs and 3.52 vs HCs, P<0.01), CM (OR: 1.69 vs AIRDs and 6.23 vs HCs, P<0.01) and mental health disorders (MHDs) (OR: 1.33 vs oAIRDs and 2.63 vs HCs, P<0.01). Among the IIM patients, those with comorbidities or MHDs had lower PROMIS Global Physical (PGP), PROMIS Global Mental (PGM), and PROMIS Physical Function (SF10) scores, and higher fatigue (F4a) scores (all P<0.001). PGP, PGM, SF10a and F4a were influenced by age, active disease, BM and MHDs. Four distinct clusters were identified among the IIMs according to comorbidities and PROMIS scores. Conclusion: Patients with IIMs have a higher burden of comorbidities that influence physical and mental health, identifiable as clinical clusters for optimized and holistic management approaches.

Original language	English
Pages (from-to)	2133-2142
Number of pages	10
Journal	Rheumatology
Volume	64
Issue number	4
DOIs	https://doi.org/10.1093/rheumatology/keae520
Publication status	Published - 1 Apr 2025

Keywords

autoinflammatory condition
comorbidity
myositis
observational studies
quality of life

Access to Document

10.1093/rheumatology/keae520

Cite this

@article{17e3ce8c565e4b0e99291352ad0064db,

title = "The impact of multimorbidity on Quality of Life in inflammatory myopathies: A cluster analysis from the COVAD dataset",

abstract = "Objective: The presence of comorbidities can substantially affect patients{\textquoteright} quality of life, but data regarding their impact on idiopathic inflammatory myopathies (IIMs) are limited. Methods: We examined the prevalence of comorbidities in IIM patients, other autoimmune rheumatic diseases (oAIRDs) and healthy controls (HCs), using data from the self-reported COVAD-2 survey. We defined basic multimorbidity (BM) as the presence of ≥2 non-rheumatic chronic conditions and complex multimorbidity (CM) as the presence of ≥3 non-rheumatic chronic conditions affecting ≥3 organ systems. Hierarchical clustering on principal components was performed for grouping. Results: Among the COVAD respondents, 1558 IIMs, 4591 oAIRDs and 3652 HCs were analysed. IIMs exhibited a high burden of comorbidities (odds ratio [OR]: 1.62 vs oAIRDs and 2.95 vs HCs, P<0.01), BM (OR: 1.66 vs oAIRDs and 3.52 vs HCs, P<0.01), CM (OR: 1.69 vs AIRDs and 6.23 vs HCs, P<0.01) and mental health disorders (MHDs) (OR: 1.33 vs oAIRDs and 2.63 vs HCs, P<0.01). Among the IIM patients, those with comorbidities or MHDs had lower PROMIS Global Physical (PGP), PROMIS Global Mental (PGM), and PROMIS Physical Function (SF10) scores, and higher fatigue (F4a) scores (all P<0.001). PGP, PGM, SF10a and F4a were influenced by age, active disease, BM and MHDs. Four distinct clusters were identified among the IIMs according to comorbidities and PROMIS scores. Conclusion: Patients with IIMs have a higher burden of comorbidities that influence physical and mental health, identifiable as clinical clusters for optimized and holistic management approaches.",

keywords = "autoinflammatory condition, comorbidity, myositis, observational studies, quality of life",

author = "\{on behalf of CoVAD Study Group\} and Marco Fornaro and Vincenzo Venerito and Pellico, \{Maria Rosa\} and Florenzo Iannone and Mrudula Joshi and Chen, \{Yi Ming\} and Tan, \{Ai Lyn\} and Sreoshy Saha and Tulika Chatterjee and Vishwesh Agarwal and Shinjo, \{Samuel Katsuyuki\} and Hoff, \{Leonardo Santos\} and Esha Kadam and Nelly Ziade and Tsvetelina Velikova and Hasan, \{A. T.M.Tanveer\} and Russka Shumnalieva and Marcin Milchert and Tan, \{Chou Luan\} and Gracia-Ramos, \{Abraham Edgar\} and Lorenzo Cavagna and Binit Vaidya and Masataka Kuwana and Shaharir, \{Syahrul Sazliyana\} and Johannes Knitza and Ashima Makol and Tehozol, \{Erick Adrian Zamora\} and Serrano, \{Jorge Rojas\} and Hussein Halabi and Dzifa Dey and Toro-Guti{\'e}rrez, \{Carlos Enrique\} and Goo, \{Phonpen Akarawatcharangura\} and Caballero-Uribe, \{Carlo V.\} and Oliver Distler and Wanruchada Katchamart and Jessica Day and Ioannis Parodis and Elena Nikiphorou and Hector Chinoy and Vikas Agarwal and Latika Gupta and Parikshit Sen and Mahnoor Javaid and Laura Andreoli and Daniele Lini and Karen Schreiber and Arvind Nune and Aarat Patel and Pauling, \{John D.\} and Chris Wincup",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology.",

year = "2025",

month = apr,

day = "1",

doi = "10.1093/rheumatology/keae520",

language = "English",

volume = "64",

pages = "2133--2142",

journal = "Rheumatology",

issn = "1462-0324",

publisher = "Oxford University Press",

number = "4",

}

TY - JOUR

T1 - The impact of multimorbidity on Quality of Life in inflammatory myopathies

T2 - A cluster analysis from the COVAD dataset

AU - on behalf of CoVAD Study Group

AU - Fornaro, Marco

AU - Venerito, Vincenzo

AU - Pellico, Maria Rosa

AU - Iannone, Florenzo

AU - Joshi, Mrudula

AU - Chen, Yi Ming

AU - Tan, Ai Lyn

AU - Saha, Sreoshy

AU - Chatterjee, Tulika

AU - Agarwal, Vishwesh

AU - Shinjo, Samuel Katsuyuki

AU - Hoff, Leonardo Santos

AU - Kadam, Esha

AU - Ziade, Nelly

AU - Velikova, Tsvetelina

AU - Hasan, A. T.M.Tanveer

AU - Shumnalieva, Russka

AU - Milchert, Marcin

AU - Tan, Chou Luan

AU - Gracia-Ramos, Abraham Edgar

AU - Cavagna, Lorenzo

AU - Vaidya, Binit

AU - Kuwana, Masataka

AU - Shaharir, Syahrul Sazliyana

AU - Knitza, Johannes

AU - Makol, Ashima

AU - Tehozol, Erick Adrian Zamora

AU - Serrano, Jorge Rojas

AU - Halabi, Hussein

AU - Dey, Dzifa

AU - Toro-Gutiérrez, Carlos Enrique

AU - Goo, Phonpen Akarawatcharangura

AU - Caballero-Uribe, Carlo V.

AU - Distler, Oliver

AU - Katchamart, Wanruchada

AU - Day, Jessica

AU - Parodis, Ioannis

AU - Nikiphorou, Elena

AU - Chinoy, Hector

AU - Agarwal, Vikas

AU - Gupta, Latika

AU - Sen, Parikshit

AU - Javaid, Mahnoor

AU - Andreoli, Laura

AU - Lini, Daniele

AU - Schreiber, Karen

AU - Nune, Arvind

AU - Patel, Aarat

AU - Pauling, John D.

AU - Wincup, Chris

PY - 2025/4/1

Y1 - 2025/4/1

N2 - Objective: The presence of comorbidities can substantially affect patients’ quality of life, but data regarding their impact on idiopathic inflammatory myopathies (IIMs) are limited. Methods: We examined the prevalence of comorbidities in IIM patients, other autoimmune rheumatic diseases (oAIRDs) and healthy controls (HCs), using data from the self-reported COVAD-2 survey. We defined basic multimorbidity (BM) as the presence of ≥2 non-rheumatic chronic conditions and complex multimorbidity (CM) as the presence of ≥3 non-rheumatic chronic conditions affecting ≥3 organ systems. Hierarchical clustering on principal components was performed for grouping. Results: Among the COVAD respondents, 1558 IIMs, 4591 oAIRDs and 3652 HCs were analysed. IIMs exhibited a high burden of comorbidities (odds ratio [OR]: 1.62 vs oAIRDs and 2.95 vs HCs, P<0.01), BM (OR: 1.66 vs oAIRDs and 3.52 vs HCs, P<0.01), CM (OR: 1.69 vs AIRDs and 6.23 vs HCs, P<0.01) and mental health disorders (MHDs) (OR: 1.33 vs oAIRDs and 2.63 vs HCs, P<0.01). Among the IIM patients, those with comorbidities or MHDs had lower PROMIS Global Physical (PGP), PROMIS Global Mental (PGM), and PROMIS Physical Function (SF10) scores, and higher fatigue (F4a) scores (all P<0.001). PGP, PGM, SF10a and F4a were influenced by age, active disease, BM and MHDs. Four distinct clusters were identified among the IIMs according to comorbidities and PROMIS scores. Conclusion: Patients with IIMs have a higher burden of comorbidities that influence physical and mental health, identifiable as clinical clusters for optimized and holistic management approaches.

AB - Objective: The presence of comorbidities can substantially affect patients’ quality of life, but data regarding their impact on idiopathic inflammatory myopathies (IIMs) are limited. Methods: We examined the prevalence of comorbidities in IIM patients, other autoimmune rheumatic diseases (oAIRDs) and healthy controls (HCs), using data from the self-reported COVAD-2 survey. We defined basic multimorbidity (BM) as the presence of ≥2 non-rheumatic chronic conditions and complex multimorbidity (CM) as the presence of ≥3 non-rheumatic chronic conditions affecting ≥3 organ systems. Hierarchical clustering on principal components was performed for grouping. Results: Among the COVAD respondents, 1558 IIMs, 4591 oAIRDs and 3652 HCs were analysed. IIMs exhibited a high burden of comorbidities (odds ratio [OR]: 1.62 vs oAIRDs and 2.95 vs HCs, P<0.01), BM (OR: 1.66 vs oAIRDs and 3.52 vs HCs, P<0.01), CM (OR: 1.69 vs AIRDs and 6.23 vs HCs, P<0.01) and mental health disorders (MHDs) (OR: 1.33 vs oAIRDs and 2.63 vs HCs, P<0.01). Among the IIM patients, those with comorbidities or MHDs had lower PROMIS Global Physical (PGP), PROMIS Global Mental (PGM), and PROMIS Physical Function (SF10) scores, and higher fatigue (F4a) scores (all P<0.001). PGP, PGM, SF10a and F4a were influenced by age, active disease, BM and MHDs. Four distinct clusters were identified among the IIMs according to comorbidities and PROMIS scores. Conclusion: Patients with IIMs have a higher burden of comorbidities that influence physical and mental health, identifiable as clinical clusters for optimized and holistic management approaches.

KW - autoinflammatory condition

KW - comorbidity

KW - myositis

KW - observational studies

KW - quality of life

UR - https://www.scopus.com/pages/publications/105002248724

U2 - 10.1093/rheumatology/keae520

DO - 10.1093/rheumatology/keae520

M3 - Review article

C2 - 39324556

AN - SCOPUS:105002248724

SN - 1462-0324

VL - 64

SP - 2133

EP - 2142

JO - Rheumatology

JF - Rheumatology

IS - 4

ER -

The impact of multimorbidity on Quality of Life in inflammatory myopathies: A cluster analysis from the COVAD dataset

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this