The effects of mosquito saliva on dengue virus infectivity in humans

Sineewanlaya Wichit; Pauline Ferraris; Valérie Choumet; Dorothée Missé

doi:10.1016/j.coviro.2016.10.001

The effects of mosquito saliva on dengue virus infectivity in humans

Sineewanlaya Wichit
, Pauline Ferraris
, Valérie Choumet
, Dorothée Missé

CNRS Centre National de la Recherche Scientifique
Environment and Infectious Risks Unit
Institut Pasteur, Paris

Research output: Contribution to journal › Review article › peer-review

26 Citations (Scopus)

Abstract

Arboviruses such as Dengue, Chikungunya, and Zika viruses represent a major public health problem due to globalization and propagation of susceptible vectors worldwide. Arthropod vector-derived salivary factors have the capacity to modulate human cells function by enhancing or suppressing viral replication and, therefore, modify the establishment of local and systemic viral infection. Here, we discuss how mosquito saliva may interfere with Dengue virus (DENV) infection in humans. Identification of saliva factors that enhance infectivity will allow the production of vector-based vaccines and therapeutics that would interfere with viral transmission by targeting arthropod saliva components. Understanding the role of salivary proteins in DENV transmission will provide tools to control not only Dengue but also other arboviral diseases transmitted by the same vectors.

Original language	English
Pages (from-to)	139-145
Number of pages	7
Journal	Current Opinion in Virology
Volume	21
DOIs	https://doi.org/10.1016/j.coviro.2016.10.001
Publication status	Published - 1 Dec 2016
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1016/j.coviro.2016.10.001

Cite this

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title = "The effects of mosquito saliva on dengue virus infectivity in humans",

abstract = "Arboviruses such as Dengue, Chikungunya, and Zika viruses represent a major public health problem due to globalization and propagation of susceptible vectors worldwide. Arthropod vector-derived salivary factors have the capacity to modulate human cells function by enhancing or suppressing viral replication and, therefore, modify the establishment of local and systemic viral infection. Here, we discuss how mosquito saliva may interfere with Dengue virus (DENV) infection in humans. Identification of saliva factors that enhance infectivity will allow the production of vector-based vaccines and therapeutics that would interfere with viral transmission by targeting arthropod saliva components. Understanding the role of salivary proteins in DENV transmission will provide tools to control not only Dengue but also other arboviral diseases transmitted by the same vectors.",

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T1 - The effects of mosquito saliva on dengue virus infectivity in humans

AU - Wichit, Sineewanlaya

AU - Ferraris, Pauline

AU - Choumet, Valérie

AU - Missé, Dorothée

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Arboviruses such as Dengue, Chikungunya, and Zika viruses represent a major public health problem due to globalization and propagation of susceptible vectors worldwide. Arthropod vector-derived salivary factors have the capacity to modulate human cells function by enhancing or suppressing viral replication and, therefore, modify the establishment of local and systemic viral infection. Here, we discuss how mosquito saliva may interfere with Dengue virus (DENV) infection in humans. Identification of saliva factors that enhance infectivity will allow the production of vector-based vaccines and therapeutics that would interfere with viral transmission by targeting arthropod saliva components. Understanding the role of salivary proteins in DENV transmission will provide tools to control not only Dengue but also other arboviral diseases transmitted by the same vectors.

AB - Arboviruses such as Dengue, Chikungunya, and Zika viruses represent a major public health problem due to globalization and propagation of susceptible vectors worldwide. Arthropod vector-derived salivary factors have the capacity to modulate human cells function by enhancing or suppressing viral replication and, therefore, modify the establishment of local and systemic viral infection. Here, we discuss how mosquito saliva may interfere with Dengue virus (DENV) infection in humans. Identification of saliva factors that enhance infectivity will allow the production of vector-based vaccines and therapeutics that would interfere with viral transmission by targeting arthropod saliva components. Understanding the role of salivary proteins in DENV transmission will provide tools to control not only Dengue but also other arboviral diseases transmitted by the same vectors.

UR - https://www.scopus.com/pages/publications/84992202398

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DO - 10.1016/j.coviro.2016.10.001

M3 - Review article

C2 - 27770704

AN - SCOPUS:84992202398

SN - 1879-6257

VL - 21

SP - 139

EP - 145

JO - Current Opinion in Virology

JF - Current Opinion in Virology

ER -

The effects of mosquito saliva on dengue virus infectivity in humans

Abstract

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