Skip to main navigation Skip to search Skip to main content

The accumulation of beneficial mutations and convergence to a Poisson process

  • Mahidol University
  • University of California, San Diego

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We consider a model of a population with fixed size N, which is subjected to an unlimited supply of beneficial mutations at a constant rate μN. Individuals with k beneficial mutations have the fitness (1+sN)k. Each individual dies at rate 1 and is replaced by a random individual chosen with probability proportional to its fitness. We show that when μN≪1/(NlogN) and N−η≪sN≪1 for some η<1, the fixation times of beneficial mutations, after a time scaling, converge to the times of a Poisson process, even though for some choices of sN and μN satisfying these conditions, there will sometimes be multiple beneficial mutations with distinct origins in the population, competing against each other.

Original languageEnglish
Article number104578
JournalStochastic Processes and their Applications
Volume183
DOIs
Publication statusPublished - May 2025
Externally publishedYes

Keywords

  • Mutation
  • Poisson process
  • Population model
  • Selection

Fingerprint

Dive into the research topics of 'The accumulation of beneficial mutations and convergence to a Poisson process'. Together they form a unique fingerprint.

Cite this