Synthesis of the Repeating Unit of Capsular Polysaccharide Staphylococcus aureus Type 5 to Study Chemical Activation and Conjugation of Native CP5

Jagodige P. Yasomanee; Satsawat Visansirikul; Papapida Pornsuriyasak; Melissa Thompson; Stephen A. Kolodziej; Alexei V. Demchenko

doi:10.1021/acs.joc.6b00910

Synthesis of the Repeating Unit of Capsular Polysaccharide Staphylococcus aureus Type 5 to Study Chemical Activation and Conjugation of Native CP5

Jagodige P. Yasomanee
, Satsawat Visansirikul
, Papapida Pornsuriyasak
, Melissa Thompson
, Stephen A. Kolodziej
, Alexei V. Demchenko

Department of Chemistry and Biochemistry
Pfizer Inc.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The chemical synthesis of the repeating unit of S. aureus capsular polysaccharide type 5 equipped with capping methyl groups at the points of propagation of the polysaccharide sequence is described. This model compound was designed to study activation of the full length polysaccharide for conjugation to a carrier protein.

Original language	English
Pages (from-to)	5981-5987
Number of pages	7
Journal	Journal of Organic Chemistry
Volume	81
Issue number	14
DOIs	https://doi.org/10.1021/acs.joc.6b00910
Publication status	Published - 15 Jul 2016
Externally published	Yes

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10.1021/acs.joc.6b00910

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title = "Synthesis of the Repeating Unit of Capsular Polysaccharide Staphylococcus aureus Type 5 to Study Chemical Activation and Conjugation of Native CP5",

abstract = "The chemical synthesis of the repeating unit of S. aureus capsular polysaccharide type 5 equipped with capping methyl groups at the points of propagation of the polysaccharide sequence is described. This model compound was designed to study activation of the full length polysaccharide for conjugation to a carrier protein.",

author = "Yasomanee, \{Jagodige P.\} and Satsawat Visansirikul and Papapida Pornsuriyasak and Melissa Thompson and Kolodziej, \{Stephen A.\} and Demchenko, \{Alexei V.\}",

note = "Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

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day = "15",

doi = "10.1021/acs.joc.6b00910",

language = "English",

volume = "81",

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journal = "Journal of Organic Chemistry",

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publisher = "American Chemical Society",

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Synthesis of the Repeating Unit of Capsular Polysaccharide Staphylococcus aureus Type 5 to Study Chemical Activation and Conjugation of Native CP5. / Yasomanee, Jagodige P.; Visansirikul, Satsawat; Pornsuriyasak, Papapida et al.
In: Journal of Organic Chemistry, Vol. 81, No. 14, 15.07.2016, p. 5981-5987.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis of the Repeating Unit of Capsular Polysaccharide Staphylococcus aureus Type 5 to Study Chemical Activation and Conjugation of Native CP5

AU - Yasomanee, Jagodige P.

AU - Visansirikul, Satsawat

AU - Pornsuriyasak, Papapida

AU - Thompson, Melissa

AU - Kolodziej, Stephen A.

AU - Demchenko, Alexei V.

PY - 2016/7/15

Y1 - 2016/7/15

N2 - The chemical synthesis of the repeating unit of S. aureus capsular polysaccharide type 5 equipped with capping methyl groups at the points of propagation of the polysaccharide sequence is described. This model compound was designed to study activation of the full length polysaccharide for conjugation to a carrier protein.

AB - The chemical synthesis of the repeating unit of S. aureus capsular polysaccharide type 5 equipped with capping methyl groups at the points of propagation of the polysaccharide sequence is described. This model compound was designed to study activation of the full length polysaccharide for conjugation to a carrier protein.

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U2 - 10.1021/acs.joc.6b00910

DO - 10.1021/acs.joc.6b00910

M3 - Article

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AN - SCOPUS:84978471898

SN - 0022-3263

VL - 81

SP - 5981

EP - 5987

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 14

ER -

Synthesis of the Repeating Unit of Capsular Polysaccharide Staphylococcus aureus Type 5 to Study Chemical Activation and Conjugation of Native CP5

Abstract

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