Synthesis and investigations of mineral ions-loaded apatite from fish scale and PLA/chitosan composite for bone scaffolds

Weeraphat Pon-On; Panan Suntornsaratoon; Narattaphol Charoenphandhu; Jirawan Thongbunchoo; Nateetip Krishnamra; I. Ming Tang

doi:10.1016/j.matlet.2018.03.063

Synthesis and investigations of mineral ions-loaded apatite from fish scale and PLA/chitosan composite for bone scaffolds

Weeraphat Pon-On
, Panan Suntornsaratoon
, Narattaphol Charoenphandhu
, Jirawan Thongbunchoo
, Nateetip Krishnamra
, I. Ming Tang

Department of Physiology

Kasetsart University
Mahidol University
K. Mongkut's Univ. Technol. Thonburi

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

In this study, composite scaffolds consisting of mineral ion-loaded hydroxyapatite derived from fish scale (mHAFS) in a poly(lactic acid) (PLA)/chitosan (Chi) matrix (mHAFS@PLAChi) were fabricated by an in situ blending technique. Mineral ion loaded HAFS was successfully converted into mHAFS via the hydrothermal heating of HAFS in a SBF (simulated body fluid) solution. The composite mHAFS with PLAChi showed a compressive strength of 20 MPa and a compressive modulus of 539.88 MPa with a microporous structure. In vitro investigation showed that the UMR-106 cells adhered well and proliferated on the mHAFS@PLAChi surface. Most importantly it improved the cell viability and alkaline phosphate (ALP) activity. These findings suggest that these synthesized materials have great potential for use in bone tissue engineering.

Original language	English
Pages (from-to)	143-146
Number of pages	4
Journal	Materials Letters
Volume	221
DOIs	https://doi.org/10.1016/j.matlet.2018.03.063
Publication status	Published - 15 Jun 2018

Keywords

Bone tissue engineering
Composite scaffolds
Fish scale
Hydroxyapatite
Natural resource

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10.1016/j.matlet.2018.03.063

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title = "Synthesis and investigations of mineral ions-loaded apatite from fish scale and PLA/chitosan composite for bone scaffolds",

abstract = "In this study, composite scaffolds consisting of mineral ion-loaded hydroxyapatite derived from fish scale (mHAFS) in a poly(lactic acid) (PLA)/chitosan (Chi) matrix (mHAFS@PLAChi) were fabricated by an in situ blending technique. Mineral ion loaded HAFS was successfully converted into mHAFS via the hydrothermal heating of HAFS in a SBF (simulated body fluid) solution. The composite mHAFS with PLAChi showed a compressive strength of 20 MPa and a compressive modulus of 539.88 MPa with a microporous structure. In vitro investigation showed that the UMR-106 cells adhered well and proliferated on the mHAFS@PLAChi surface. Most importantly it improved the cell viability and alkaline phosphate (ALP) activity. These findings suggest that these synthesized materials have great potential for use in bone tissue engineering.",

keywords = "Bone tissue engineering, Composite scaffolds, Fish scale, Hydroxyapatite, Natural resource",

author = "Weeraphat Pon-On and Panan Suntornsaratoon and Narattaphol Charoenphandhu and Jirawan Thongbunchoo and Nateetip Krishnamra and Tang, \{I. Ming\}",

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T1 - Synthesis and investigations of mineral ions-loaded apatite from fish scale and PLA/chitosan composite for bone scaffolds

AU - Pon-On, Weeraphat

AU - Suntornsaratoon, Panan

AU - Charoenphandhu, Narattaphol

AU - Thongbunchoo, Jirawan

AU - Krishnamra, Nateetip

AU - Tang, I. Ming

PY - 2018/6/15

Y1 - 2018/6/15

N2 - In this study, composite scaffolds consisting of mineral ion-loaded hydroxyapatite derived from fish scale (mHAFS) in a poly(lactic acid) (PLA)/chitosan (Chi) matrix (mHAFS@PLAChi) were fabricated by an in situ blending technique. Mineral ion loaded HAFS was successfully converted into mHAFS via the hydrothermal heating of HAFS in a SBF (simulated body fluid) solution. The composite mHAFS with PLAChi showed a compressive strength of 20 MPa and a compressive modulus of 539.88 MPa with a microporous structure. In vitro investigation showed that the UMR-106 cells adhered well and proliferated on the mHAFS@PLAChi surface. Most importantly it improved the cell viability and alkaline phosphate (ALP) activity. These findings suggest that these synthesized materials have great potential for use in bone tissue engineering.

AB - In this study, composite scaffolds consisting of mineral ion-loaded hydroxyapatite derived from fish scale (mHAFS) in a poly(lactic acid) (PLA)/chitosan (Chi) matrix (mHAFS@PLAChi) were fabricated by an in situ blending technique. Mineral ion loaded HAFS was successfully converted into mHAFS via the hydrothermal heating of HAFS in a SBF (simulated body fluid) solution. The composite mHAFS with PLAChi showed a compressive strength of 20 MPa and a compressive modulus of 539.88 MPa with a microporous structure. In vitro investigation showed that the UMR-106 cells adhered well and proliferated on the mHAFS@PLAChi surface. Most importantly it improved the cell viability and alkaline phosphate (ALP) activity. These findings suggest that these synthesized materials have great potential for use in bone tissue engineering.

KW - Bone tissue engineering

KW - Composite scaffolds

KW - Fish scale

KW - Hydroxyapatite

KW - Natural resource

UR - https://www.scopus.com/pages/publications/85044130494

U2 - 10.1016/j.matlet.2018.03.063

DO - 10.1016/j.matlet.2018.03.063

M3 - Article

AN - SCOPUS:85044130494

SN - 0167-577X

VL - 221

SP - 143

EP - 146

JO - Materials Letters

JF - Materials Letters

ER -

Synthesis and investigations of mineral ions-loaded apatite from fish scale and PLA/chitosan composite for bone scaffolds

Abstract

Keywords

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