Survey of antimicrobial resistance in clinical Burkholderia pseudomallei isolates over two decades in Northeast Thailand

Vanaporn Wuthiekanun; Premjit Amornchai; Natnaree Saiprom; Narisara Chantratita; Wirongrong Chierakul; Gavin C.K.W. Koh; Wipada Chaowagul; Nicholas P.J. Day; Direk Limmathurotsakul; Sharon J. Peacock

doi:10.1128/AAC.05517-11

Survey of antimicrobial resistance in clinical Burkholderia pseudomallei isolates over two decades in Northeast Thailand

Vanaporn Wuthiekanun
, Premjit Amornchai
, Natnaree Saiprom
, Narisara Chantratita
, Wirongrong Chierakul
, Gavin C.K.W. Koh
, Wipada Chaowagul
, Nicholas P.J. Day
, Direk Limmathurotsakul
, Sharon J. Peacock

Mahidol University
Faculty of Tropical Medicine, Mahidol University
Department of Medicine
Sapasittiprasong Hospital
Nuffield Department of Medicine

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

Abstract

A 21-year survey conducted in northeast Thailand of antimicrobial resistance to parenteral antimicrobial drugs used to treat melioidosis identified 24/4,021 (0.6%) patients with one or more isolates resistant to ceftazidime (n ∇ 8), amoxicillin-clavulanic acid (n ∇ 4), or both drugs (n ∇ 12). Two cases were identified at admission, and the remainder were detected a median of 15 days after starting antimicrobial therapy. Resistance to carbapenem drugs was not detected. These findings support the current prescribing recommendations for melioidosis.

Original language	English
Pages (from-to)	5388-5391
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	55
Issue number	11
DOIs	https://doi.org/10.1128/AAC.05517-11
Publication status	Published - Nov 2011

Access to Document

10.1128/AAC.05517-11

Cite this

Wuthiekanun, V., Amornchai, P., Saiprom, N., Chantratita, N., Chierakul, W., Koh, G. C. K. W., Chaowagul, W., Day, N. P. J., Limmathurotsakul, D., & Peacock, S. J. (2011). Survey of antimicrobial resistance in clinical Burkholderia pseudomallei isolates over two decades in Northeast Thailand. Antimicrobial Agents and Chemotherapy, 55(11), 5388-5391. https://doi.org/10.1128/AAC.05517-11

@article{baa227422c7143af98b6a358c461be92,

title = "Survey of antimicrobial resistance in clinical Burkholderia pseudomallei isolates over two decades in Northeast Thailand",

abstract = "A 21-year survey conducted in northeast Thailand of antimicrobial resistance to parenteral antimicrobial drugs used to treat melioidosis identified 24/4,021 (0.6\%) patients with one or more isolates resistant to ceftazidime (n ∇ 8), amoxicillin-clavulanic acid (n ∇ 4), or both drugs (n ∇ 12). Two cases were identified at admission, and the remainder were detected a median of 15 days after starting antimicrobial therapy. Resistance to carbapenem drugs was not detected. These findings support the current prescribing recommendations for melioidosis.",

author = "Vanaporn Wuthiekanun and Premjit Amornchai and Natnaree Saiprom and Narisara Chantratita and Wirongrong Chierakul and Koh, \{Gavin C.K.W.\} and Wipada Chaowagul and Day, \{Nicholas P.J.\} and Direk Limmathurotsakul and Peacock, \{Sharon J.\}",

year = "2011",

month = nov,

doi = "10.1128/AAC.05517-11",

language = "English",

volume = "55",

pages = "5388--5391",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "11",

}

Wuthiekanun, V, Amornchai, P, Saiprom, N, Chantratita, N , Chierakul, W, Koh, GCKW, Chaowagul, W, Day, NPJ, Limmathurotsakul, D & Peacock, SJ 2011, 'Survey of antimicrobial resistance in clinical Burkholderia pseudomallei isolates over two decades in Northeast Thailand', Antimicrobial Agents and Chemotherapy, vol. 55, no. 11, pp. 5388-5391. https://doi.org/10.1128/AAC.05517-11

TY - JOUR

T1 - Survey of antimicrobial resistance in clinical Burkholderia pseudomallei isolates over two decades in Northeast Thailand

AU - Wuthiekanun, Vanaporn

AU - Amornchai, Premjit

AU - Saiprom, Natnaree

AU - Chantratita, Narisara

AU - Chierakul, Wirongrong

AU - Koh, Gavin C.K.W.

AU - Chaowagul, Wipada

AU - Day, Nicholas P.J.

AU - Limmathurotsakul, Direk

AU - Peacock, Sharon J.

PY - 2011/11

Y1 - 2011/11

N2 - A 21-year survey conducted in northeast Thailand of antimicrobial resistance to parenteral antimicrobial drugs used to treat melioidosis identified 24/4,021 (0.6%) patients with one or more isolates resistant to ceftazidime (n ∇ 8), amoxicillin-clavulanic acid (n ∇ 4), or both drugs (n ∇ 12). Two cases were identified at admission, and the remainder were detected a median of 15 days after starting antimicrobial therapy. Resistance to carbapenem drugs was not detected. These findings support the current prescribing recommendations for melioidosis.

AB - A 21-year survey conducted in northeast Thailand of antimicrobial resistance to parenteral antimicrobial drugs used to treat melioidosis identified 24/4,021 (0.6%) patients with one or more isolates resistant to ceftazidime (n ∇ 8), amoxicillin-clavulanic acid (n ∇ 4), or both drugs (n ∇ 12). Two cases were identified at admission, and the remainder were detected a median of 15 days after starting antimicrobial therapy. Resistance to carbapenem drugs was not detected. These findings support the current prescribing recommendations for melioidosis.

UR - https://www.scopus.com/pages/publications/80054710806

U2 - 10.1128/AAC.05517-11

DO - 10.1128/AAC.05517-11

M3 - Article

C2 - 21876049

AN - SCOPUS:80054710806

SN - 0066-4804

VL - 55

SP - 5388

EP - 5391

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

ER -

Survey of antimicrobial resistance in clinical Burkholderia pseudomallei isolates over two decades in Northeast Thailand

Abstract

Access to Document

Other files and links

Fingerprint

Cite this