Supramolecular electrochemical detection of bisphenol A using a melamine-functionalized reduced graphene oxide modified screen-printed electrode

Detection of bisphenol A (BPA), an endocrine disruptor, requires rapid and reliable methods to ensure water safety. In the current work, we present a supramolecular electrochemical sensor based on a melamine-immobilized reduced graphene oxide-modified screen-printed carbon electrode (Mel-rGO SPE) for the determination of BPA. The sensing design exploits dual supramolecular interactions: hydrogen bonding between melamine's amine groups and BPA's hydroxyl moieties, and π–π stacking between their aromatic rings. While rGO significantly enhances electron transfer, these synergistic effects improve device sensitivity. A Mel-rGO SPE was fabricated using an ink-mixing approach to produce a uniform and robust sensor. BPA detection was performed using cyclic voltammetry, and the anodic peak potential was 0.32 V. The current response provided a good correlation with BPA concentrations in the range of 1–250 μM. The detection limit was low, 0.23 μM. The Mel-rGO SPE was successfully applied to determine BPA in polycarbonate bottled water. These promising results indicate that the developed sensor is an alternative device for rapid screening of BPA contamination of water samples.