Site-Specific Synthesis of β-Fluorinated γ-Butyrolactams via Decarboxylative Fluorination of β-Carboxyl-γ-Butyrolactams

Supasorn Phae-nok; Manat Pohmakotr; Chutima Kuhakarn; Vichai Reutrakul; Darunee Soorukram

doi:10.1002/ejoc.201900685

Site-Specific Synthesis of β-Fluorinated γ-Butyrolactams via Decarboxylative Fluorination of β-Carboxyl-γ-Butyrolactams

Supasorn Phae-nok
, Manat Pohmakotr
, Chutima Kuhakarn
, Vichai Reutrakul
, Darunee Soorukram

Mahidol University

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Monofluorinated cyclic nitrogen-containing compounds are synthetically useful scaffolds in organic synthesis and medicinal applications. In this report, AgNO₃ mediated decarboxylative fluorination of β-carboxyl-γ-butyrolactams using Selectfluor® as a fluorine source was described to achieve a site-specific synthesis of β-fluorinated γ-butyrolactams.

Original language	English
Pages (from-to)	4710-4720
Number of pages	11
Journal	European Journal of Organic Chemistry
Volume	2019
Issue number	29
DOIs	https://doi.org/10.1002/ejoc.201900685
Publication status	Published - 7 Aug 2019
Externally published	Yes

Keywords

Decarboxylation
Fluorinated lactams
Fluorination
γ-Butyrolactams

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10.1002/ejoc.201900685

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title = "Site-Specific Synthesis of β-Fluorinated γ-Butyrolactams via Decarboxylative Fluorination of β-Carboxyl-γ-Butyrolactams",

abstract = "Monofluorinated cyclic nitrogen-containing compounds are synthetically useful scaffolds in organic synthesis and medicinal applications. In this report, AgNO3 mediated decarboxylative fluorination of β-carboxyl-γ-butyrolactams using Selectfluor{\textregistered} as a fluorine source was described to achieve a site-specific synthesis of β-fluorinated γ-butyrolactams.",

keywords = "Decarboxylation, Fluorinated lactams, Fluorination, γ-Butyrolactams",

author = "Supasorn Phae-nok and Manat Pohmakotr and Chutima Kuhakarn and Vichai Reutrakul and Darunee Soorukram",

note = "Publisher Copyright: {\textcopyright} 2019 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2019",

month = aug,

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doi = "10.1002/ejoc.201900685",

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T1 - Site-Specific Synthesis of β-Fluorinated γ-Butyrolactams via Decarboxylative Fluorination of β-Carboxyl-γ-Butyrolactams

AU - Phae-nok, Supasorn

AU - Pohmakotr, Manat

AU - Kuhakarn, Chutima

AU - Reutrakul, Vichai

AU - Soorukram, Darunee

PY - 2019/8/7

Y1 - 2019/8/7

N2 - Monofluorinated cyclic nitrogen-containing compounds are synthetically useful scaffolds in organic synthesis and medicinal applications. In this report, AgNO3 mediated decarboxylative fluorination of β-carboxyl-γ-butyrolactams using Selectfluor® as a fluorine source was described to achieve a site-specific synthesis of β-fluorinated γ-butyrolactams.

AB - Monofluorinated cyclic nitrogen-containing compounds are synthetically useful scaffolds in organic synthesis and medicinal applications. In this report, AgNO3 mediated decarboxylative fluorination of β-carboxyl-γ-butyrolactams using Selectfluor® as a fluorine source was described to achieve a site-specific synthesis of β-fluorinated γ-butyrolactams.

KW - Decarboxylation

KW - Fluorinated lactams

KW - Fluorination

KW - γ-Butyrolactams

UR - https://www.scopus.com/pages/publications/85069882375

U2 - 10.1002/ejoc.201900685

DO - 10.1002/ejoc.201900685

M3 - Article

AN - SCOPUS:85069882375

SN - 1434-193X

VL - 2019

SP - 4710

EP - 4720

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 29

ER -

Site-Specific Synthesis of β-Fluorinated γ-Butyrolactams via Decarboxylative Fluorination of β-Carboxyl-γ-Butyrolactams

Abstract

Keywords

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