Secondary metabolites from cultures of the ant pathogenic fungus Ophiocordyceps irangiensis BCC 2728

Siriporn Saepua; Jittra Kornsakulkarn; Patchanee Auncharoen; Pranee Rachtawee; Surisa Kongthong; Nattawut Boonyuen; David J. Harding; Tatsuo Nehira; Tienthong Thongpanchang; Chawanee Thongpanchang

doi:10.1080/14786419.2020.1713119

Secondary metabolites from cultures of the ant pathogenic fungus Ophiocordyceps irangiensis BCC 2728

Siriporn Saepua
, Jittra Kornsakulkarn
, Patchanee Auncharoen
, Pranee Rachtawee
, Surisa Kongthong
, Nattawut Boonyuen
, David J. Harding
, Tatsuo Nehira
, Tienthong Thongpanchang
, Chawanee Thongpanchang

National Science and Technology Development Agency (NSTDA)
Walailak University
Hiroshima University
Mahidol University

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Five new compounds, iranginins A–E (1–5), together with sixteen known compounds were isolated from the insect pathogenic fungus Ophiocordyceps irangiensis BCC 2728. The structures and the absolute configurations of the new compounds were established by spectroscopic analyses, the application of modified Mosher’s method (for 2), ECD calculation (for 5), and X-ray crystallographic analysis (for 4). LL-Z1640-5 and mucorisocoumarin C were active against Mycobacterium tuberculosis (MIC 41.7 and 85.0 µM, respectively), while peyroisocoumarin D exhibited cytotoxic activity (IC₅₀ 65.6 µM).

Original language	English
Pages (from-to)	3556-3561
Number of pages	6
Journal	Natural Product Research
Volume	35
Issue number	21
DOIs	https://doi.org/10.1080/14786419.2020.1713119
Publication status	Published - 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Ophiocordyceps irangiensis
Polyketides
bioactive secondary metabolites
insect pathogenic fungus

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10.1080/14786419.2020.1713119

Cite this

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title = "Secondary metabolites from cultures of the ant pathogenic fungus Ophiocordyceps irangiensis BCC 2728",

abstract = "Five new compounds, iranginins A–E (1–5), together with sixteen known compounds were isolated from the insect pathogenic fungus Ophiocordyceps irangiensis BCC 2728. The structures and the absolute configurations of the new compounds were established by spectroscopic analyses, the application of modified Mosher{\textquoteright}s method (for 2), ECD calculation (for 5), and X-ray crystallographic analysis (for 4). LL-Z1640-5 and mucorisocoumarin C were active against Mycobacterium tuberculosis (MIC 41.7 and 85.0 µM, respectively), while peyroisocoumarin D exhibited cytotoxic activity (IC50 65.6 µM).",

keywords = "Ophiocordyceps irangiensis, Polyketides, bioactive secondary metabolites, insect pathogenic fungus",

author = "Siriporn Saepua and Jittra Kornsakulkarn and Patchanee Auncharoen and Pranee Rachtawee and Surisa Kongthong and Nattawut Boonyuen and Harding, \{David J.\} and Tatsuo Nehira and Tienthong Thongpanchang and Chawanee Thongpanchang",

note = "Publisher Copyright: {\textcopyright} 2020 Informa UK Limited, trading as Taylor \& Francis Group.",

year = "2021",

doi = "10.1080/14786419.2020.1713119",

language = "English",

volume = "35",

pages = "3556--3561",

journal = "Natural Product Research",

issn = "1478-6419",

publisher = "Taylor and Francis Ltd.",

number = "21",

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TY - JOUR

T1 - Secondary metabolites from cultures of the ant pathogenic fungus Ophiocordyceps irangiensis BCC 2728

AU - Saepua, Siriporn

AU - Kornsakulkarn, Jittra

AU - Auncharoen, Patchanee

AU - Rachtawee, Pranee

AU - Kongthong, Surisa

AU - Boonyuen, Nattawut

AU - Harding, David J.

AU - Nehira, Tatsuo

AU - Thongpanchang, Tienthong

AU - Thongpanchang, Chawanee

PY - 2021

Y1 - 2021

N2 - Five new compounds, iranginins A–E (1–5), together with sixteen known compounds were isolated from the insect pathogenic fungus Ophiocordyceps irangiensis BCC 2728. The structures and the absolute configurations of the new compounds were established by spectroscopic analyses, the application of modified Mosher’s method (for 2), ECD calculation (for 5), and X-ray crystallographic analysis (for 4). LL-Z1640-5 and mucorisocoumarin C were active against Mycobacterium tuberculosis (MIC 41.7 and 85.0 µM, respectively), while peyroisocoumarin D exhibited cytotoxic activity (IC50 65.6 µM).

AB - Five new compounds, iranginins A–E (1–5), together with sixteen known compounds were isolated from the insect pathogenic fungus Ophiocordyceps irangiensis BCC 2728. The structures and the absolute configurations of the new compounds were established by spectroscopic analyses, the application of modified Mosher’s method (for 2), ECD calculation (for 5), and X-ray crystallographic analysis (for 4). LL-Z1640-5 and mucorisocoumarin C were active against Mycobacterium tuberculosis (MIC 41.7 and 85.0 µM, respectively), while peyroisocoumarin D exhibited cytotoxic activity (IC50 65.6 µM).

KW - Ophiocordyceps irangiensis

KW - Polyketides

KW - bioactive secondary metabolites

KW - insect pathogenic fungus

UR - https://www.scopus.com/pages/publications/85078025640

U2 - 10.1080/14786419.2020.1713119

DO - 10.1080/14786419.2020.1713119

M3 - Article

C2 - 31933382

AN - SCOPUS:85078025640

SN - 1478-6419

VL - 35

SP - 3556

EP - 3561

JO - Natural Product Research

JF - Natural Product Research

IS - 21

ER -

Secondary metabolites from cultures of the ant pathogenic fungus Ophiocordyceps irangiensis BCC 2728

Abstract

UN SDGs

Keywords

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