Role of Calcium sensing receptor (CaSR) in tumorigenesis

Navneet Singh; Moltira Promkan; Guangming Liu; James Varani; Subhas Chakrabarty

doi:10.1016/j.beem.2013.04.001

Role of Calcium sensing receptor (CaSR) in tumorigenesis

Navneet Singh
, Moltira Promkan
, Guangming Liu
, James Varani
, Subhas Chakrabarty

Department of Clinical Microscopy

Southern Illinois University School of Medicine and Simmons Cancer Institute
University of Michigan Medical School

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

The extracellular Ca²⁺-sensing receptor (CaSR) is a robust promoter of differentiation in colonic epithelial cells and functions as a tumor suppressor in colon cancer. CaSR mediates its biologic effects through diverse mechanisms. Loss of CaSR expression activates a myriad of stem cell-like molecular features that drive and sustain the malignant and drug-resistant phenotypes of colon cancer. This CaSR-null phenotype, however, is not irreversible and induction of CaSR expression in CaSR-null cells promotes cell death mechanisms and restores drug sensitivity. The CaSR also functions as a tumor suppressor in breast cancer and promotes cellular sensitivity to cytotoxic drugs. BRCA1 and CaSR functions intersect in breast cancer cells, and CaSR activation can rescue breast cancer cells from the deleterious effect of BRCA1 mutations.

Original language	English
Pages (from-to)	455-463
Number of pages	9
Journal	Best Practice and Research: Clinical Endocrinology and Metabolism
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/j.beem.2013.04.001
Publication status	Published - Jun 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CaSR
breast cancer
colon cancer
differentiation
drug resistance
tumor suppressor

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10.1016/j.beem.2013.04.001

Cite this

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title = "Role of Calcium sensing receptor (CaSR) in tumorigenesis",

abstract = "The extracellular Ca2+-sensing receptor (CaSR) is a robust promoter of differentiation in colonic epithelial cells and functions as a tumor suppressor in colon cancer. CaSR mediates its biologic effects through diverse mechanisms. Loss of CaSR expression activates a myriad of stem cell-like molecular features that drive and sustain the malignant and drug-resistant phenotypes of colon cancer. This CaSR-null phenotype, however, is not irreversible and induction of CaSR expression in CaSR-null cells promotes cell death mechanisms and restores drug sensitivity. The CaSR also functions as a tumor suppressor in breast cancer and promotes cellular sensitivity to cytotoxic drugs. BRCA1 and CaSR functions intersect in breast cancer cells, and CaSR activation can rescue breast cancer cells from the deleterious effect of BRCA1 mutations.",

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author = "Navneet Singh and Moltira Promkan and Guangming Liu and James Varani and Subhas Chakrabarty",

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T1 - Role of Calcium sensing receptor (CaSR) in tumorigenesis

AU - Singh, Navneet

AU - Promkan, Moltira

AU - Liu, Guangming

AU - Varani, James

AU - Chakrabarty, Subhas

PY - 2013/6

Y1 - 2013/6

N2 - The extracellular Ca2+-sensing receptor (CaSR) is a robust promoter of differentiation in colonic epithelial cells and functions as a tumor suppressor in colon cancer. CaSR mediates its biologic effects through diverse mechanisms. Loss of CaSR expression activates a myriad of stem cell-like molecular features that drive and sustain the malignant and drug-resistant phenotypes of colon cancer. This CaSR-null phenotype, however, is not irreversible and induction of CaSR expression in CaSR-null cells promotes cell death mechanisms and restores drug sensitivity. The CaSR also functions as a tumor suppressor in breast cancer and promotes cellular sensitivity to cytotoxic drugs. BRCA1 and CaSR functions intersect in breast cancer cells, and CaSR activation can rescue breast cancer cells from the deleterious effect of BRCA1 mutations.

AB - The extracellular Ca2+-sensing receptor (CaSR) is a robust promoter of differentiation in colonic epithelial cells and functions as a tumor suppressor in colon cancer. CaSR mediates its biologic effects through diverse mechanisms. Loss of CaSR expression activates a myriad of stem cell-like molecular features that drive and sustain the malignant and drug-resistant phenotypes of colon cancer. This CaSR-null phenotype, however, is not irreversible and induction of CaSR expression in CaSR-null cells promotes cell death mechanisms and restores drug sensitivity. The CaSR also functions as a tumor suppressor in breast cancer and promotes cellular sensitivity to cytotoxic drugs. BRCA1 and CaSR functions intersect in breast cancer cells, and CaSR activation can rescue breast cancer cells from the deleterious effect of BRCA1 mutations.

KW - CaSR

KW - breast cancer

KW - colon cancer

KW - differentiation

KW - drug resistance

KW - tumor suppressor

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U2 - 10.1016/j.beem.2013.04.001

DO - 10.1016/j.beem.2013.04.001

M3 - Article

AN - SCOPUS:85027945625

SN - 1521-690X

VL - 27

SP - 455

EP - 463

JO - Best Practice and Research: Clinical Endocrinology and Metabolism

JF - Best Practice and Research: Clinical Endocrinology and Metabolism

IS - 3

ER -

Role of Calcium sensing receptor (CaSR) in tumorigenesis

Abstract

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Keywords

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