Resistance of monocyte to HIV-1 infection is not due to uncoating defect

Sirawat Srichatrapimuk; Prasert Auewarakul

doi:10.1016/j.virusres.2007.02.016

Resistance of monocyte to HIV-1 infection is not due to uncoating defect

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Freshly isolated blood monocytes show an early postentry block to in vitro HIV-1 infection. Differentiation into monocyte-derived macrophages (MDMs) is required to allow HIV replication in this cell type. In this study, we investigated whether the resistance of monocyte to HIV infection stemmed from uncoating defect. Monocyte and MDM lysates induced HIV-1 core uncoating to a comparable degree. This suggests that monocyte lacks a factor(s) essential for viral reverse transcription and/or contains a factor(s) interfering with this step.

Original language	English
Pages (from-to)	277-281
Number of pages	5
Journal	Virus Research
Volume	126
Issue number	1-2
DOIs	https://doi.org/10.1016/j.virusres.2007.02.016
Publication status	Published - Jun 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HIV
Macrophage
Monocyte
Postentry
Uncoating

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10.1016/j.virusres.2007.02.016

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abstract = "Freshly isolated blood monocytes show an early postentry block to in vitro HIV-1 infection. Differentiation into monocyte-derived macrophages (MDMs) is required to allow HIV replication in this cell type. In this study, we investigated whether the resistance of monocyte to HIV infection stemmed from uncoating defect. Monocyte and MDM lysates induced HIV-1 core uncoating to a comparable degree. This suggests that monocyte lacks a factor(s) essential for viral reverse transcription and/or contains a factor(s) interfering with this step.",

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author = "Sirawat Srichatrapimuk and Prasert Auewarakul",

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AU - Srichatrapimuk, Sirawat

AU - Auewarakul, Prasert

PY - 2007/6

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N2 - Freshly isolated blood monocytes show an early postentry block to in vitro HIV-1 infection. Differentiation into monocyte-derived macrophages (MDMs) is required to allow HIV replication in this cell type. In this study, we investigated whether the resistance of monocyte to HIV infection stemmed from uncoating defect. Monocyte and MDM lysates induced HIV-1 core uncoating to a comparable degree. This suggests that monocyte lacks a factor(s) essential for viral reverse transcription and/or contains a factor(s) interfering with this step.

AB - Freshly isolated blood monocytes show an early postentry block to in vitro HIV-1 infection. Differentiation into monocyte-derived macrophages (MDMs) is required to allow HIV replication in this cell type. In this study, we investigated whether the resistance of monocyte to HIV infection stemmed from uncoating defect. Monocyte and MDM lysates induced HIV-1 core uncoating to a comparable degree. This suggests that monocyte lacks a factor(s) essential for viral reverse transcription and/or contains a factor(s) interfering with this step.

KW - HIV

KW - Macrophage

KW - Monocyte

KW - Postentry

KW - Uncoating

UR - https://www.scopus.com/pages/publications/34248143315

U2 - 10.1016/j.virusres.2007.02.016

DO - 10.1016/j.virusres.2007.02.016

M3 - Article

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EP - 281

JO - Virus Research

JF - Virus Research

IS - 1-2

ER -

Resistance of monocyte to HIV-1 infection is not due to uncoating defect

Abstract

UN SDGs

Keywords

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