Abstract
This review covers recent advances of capillary electrophoresis (CE) in pharmaceutical analysis. The principle, instrumentation, and conventional modes of CE are briefly discussed. Advances in the different CE techniques (non-aqueous CE, microemulsion electrokinetic chromatography, capillary isotachophoresis, capillary electrochromatography, and immunoaffinity CE), detection techniques (mass spectrometry, light-emitting diode, fluorescence, chemiluminescence, and contactless conductivity), on-line sample pretreatment (flow injection) and chiral separation are described. Applications of CE to assay of active pharmaceutical ingredients (APIs), drug impurity testing, chiral drug separation, and determination of APIs in biological fluids published from 2008 to 2009 are tabulated.
| Original language | English |
|---|---|
| Pages (from-to) | 29-52 |
| Number of pages | 24 |
| Journal | Analytical and Bioanalytical Chemistry |
| Volume | 398 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Sept 2010 |
Keywords
- Active pharmaceutical ingredient
- Biological fluid
- Capillary electrophoresis
- Chiral separation
- Impurity
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