Pughiinin A, a sesquiterpene from the fungus Kionochaeta pughii BCC 3878

Pattama Pittayakhajonwut; Man Theerasilp; Palangpon Kongsaeree; Amporn Rungrod; Morakot Tanticharoen; Yodhathai Thebtaranonth

doi:10.1055/s-2002-35653

Pughiinin A, a sesquiterpene from the fungus Kionochaeta pughii BCC 3878

Pattama Pittayakhajonwut
, Man Theerasilp
, Palangpon Kongsaeree
, Amporn Rungrod
, Morakot Tanticharoen
, Yodhathai Thebtaranonth

National Science and Technology Development Agency (NSTDA)
Mahidol University

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

A novel secondary metabolite, pughiinin A, together with pycnidione, mevalonolactone, and 7-hydroxy-2-methylchromanone, was isolated from the seed fungus Kionochaeta pughii BCC 3878. The chemical structure was established by spectroscopic methods and by single crystal X-ray crystallography. Pughiinin A and pycnidione exhibited in vitro antiplasmodial activity against Plasmodium falciparum (K1 strain). Pycnidione also showed anti-cancer activity against KB and BC cell lines with the IC₅₀ values of 2.0 and 1.6 μg/mL, respectively.

Original language	English
Pages (from-to)	1017-1019
Number of pages	3
Journal	Planta Medica
Volume	68
Issue number	11
DOIs	https://doi.org/10.1055/s-2002-35653
Publication status	Published - 1 Nov 2002
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-cancer activity
Antiplasmodial activity
Kionochaeta pughii
Seed fungus

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10.1055/s-2002-35653

Cite this

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title = "Pughiinin A, a sesquiterpene from the fungus Kionochaeta pughii BCC 3878",

abstract = "A novel secondary metabolite, pughiinin A, together with pycnidione, mevalonolactone, and 7-hydroxy-2-methylchromanone, was isolated from the seed fungus Kionochaeta pughii BCC 3878. The chemical structure was established by spectroscopic methods and by single crystal X-ray crystallography. Pughiinin A and pycnidione exhibited in vitro antiplasmodial activity against Plasmodium falciparum (K1 strain). Pycnidione also showed anti-cancer activity against KB and BC cell lines with the IC50 values of 2.0 and 1.6 μg/mL, respectively.",

keywords = "Anti-cancer activity, Antiplasmodial activity, Kionochaeta pughii, Seed fungus",

author = "Pattama Pittayakhajonwut and Man Theerasilp and Palangpon Kongsaeree and Amporn Rungrod and Morakot Tanticharoen and Yodhathai Thebtaranonth",

year = "2002",

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doi = "10.1055/s-2002-35653",

language = "English",

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TY - JOUR

T1 - Pughiinin A, a sesquiterpene from the fungus Kionochaeta pughii BCC 3878

AU - Pittayakhajonwut, Pattama

AU - Theerasilp, Man

AU - Kongsaeree, Palangpon

AU - Rungrod, Amporn

AU - Tanticharoen, Morakot

AU - Thebtaranonth, Yodhathai

PY - 2002/11/1

Y1 - 2002/11/1

N2 - A novel secondary metabolite, pughiinin A, together with pycnidione, mevalonolactone, and 7-hydroxy-2-methylchromanone, was isolated from the seed fungus Kionochaeta pughii BCC 3878. The chemical structure was established by spectroscopic methods and by single crystal X-ray crystallography. Pughiinin A and pycnidione exhibited in vitro antiplasmodial activity against Plasmodium falciparum (K1 strain). Pycnidione also showed anti-cancer activity against KB and BC cell lines with the IC50 values of 2.0 and 1.6 μg/mL, respectively.

AB - A novel secondary metabolite, pughiinin A, together with pycnidione, mevalonolactone, and 7-hydroxy-2-methylchromanone, was isolated from the seed fungus Kionochaeta pughii BCC 3878. The chemical structure was established by spectroscopic methods and by single crystal X-ray crystallography. Pughiinin A and pycnidione exhibited in vitro antiplasmodial activity against Plasmodium falciparum (K1 strain). Pycnidione also showed anti-cancer activity against KB and BC cell lines with the IC50 values of 2.0 and 1.6 μg/mL, respectively.

KW - Anti-cancer activity

KW - Antiplasmodial activity

KW - Kionochaeta pughii

KW - Seed fungus

UR - https://www.scopus.com/pages/publications/18744369890

U2 - 10.1055/s-2002-35653

DO - 10.1055/s-2002-35653

M3 - Article

C2 - 12451493

AN - SCOPUS:18744369890

SN - 0032-0943

VL - 68

SP - 1017

EP - 1019

JO - Planta Medica

JF - Planta Medica

IS - 11

ER -

Pughiinin A, a sesquiterpene from the fungus Kionochaeta pughii BCC 3878

Abstract

UN SDGs

Keywords

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