Production and characterization of rice bran extract encapsulated in solid lipid nanoparticles for dermal delivery

Usawadee Sakulkhu; Sanitra Jarupaiboon; Alongkot Trithong; Sirapat Prathontep; Varaporn Janyaprasert; Satit Puttipipatkhachorn; Uracha Ruktanonchai

doi:10.1109/NEMS.2007.352191

Production and characterization of rice bran extract encapsulated in solid lipid nanoparticles for dermal delivery

Usawadee Sakulkhu
, Sanitra Jarupaiboon
, Alongkot Trithong
, Sirapat Prathontep
, Varaporn Janyaprasert
, Satit Puttipipatkhachorn
, Uracha Ruktanonchai

Department of Manufacturing Pharmacy

National Science and Technology Development Agency (NSTDA)
Mahidol University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Citations (Scopus)

Abstract

Solid lipid nanoparticles (SLNs) recently gain attention as colloidal drug carriers, for both intravenous and dermal delivery. The present study focused on the preparation and some characterization of SLN associated with gamma-oryzanol of the specialized delivery systems. The nanoparticles, containing Dynasan 114 as lipid and Pluronic® F68 as emulsifying agent were prepared by hot homogenization method. Particle sizes of SLNs were in suitable range and homogenous. Moreover, SLNs containing gamma-oryzanol are stable for investigated time as suggested by size, pH, % entrapment efficiency and DSC. Moreover, HPLC chromatograms indicated that no degradation was observed within the investigated period. Therefore chosen composition and method of preparation benefit the stability of the nanoparticles, which is suitable for transdermal skin penetration.

Original language	English
Title of host publication	Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
Pages	1020-1023
Number of pages	4
DOIs	https://doi.org/10.1109/NEMS.2007.352191
Publication status	Published - 2007
Event	2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 - Bangkok, Thailand Duration: 16 Jan 2007 → 19 Jan 2007

Publication series

Name	Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

Conference

Conference	2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
Country/Territory	Thailand
City	Bangkok
Period	16/01/07 → 19/01/07

Keywords

Drug delivery
Gamma-oryzanol
Nanparticles
Solid lipid nanoparticles

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10.1109/NEMS.2007.352191

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Sakulkhu, U., Jarupaiboon, S., Trithong, A., Prathontep, S., Janyaprasert, V., Puttipipatkhachorn, S., & Ruktanonchai, U. (2007). Production and characterization of rice bran extract encapsulated in solid lipid nanoparticles for dermal delivery. In Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 (pp. 1020-1023). Article 4160494 (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007). https://doi.org/10.1109/NEMS.2007.352191

Sakulkhu, Usawadee ; Jarupaiboon, Sanitra ; Trithong, Alongkot et al. / Production and characterization of rice bran extract encapsulated in solid lipid nanoparticles for dermal delivery. Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. pp. 1020-1023 (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007).

@inproceedings{b7ffc0736d6143ffb26c099a74602df6,

title = "Production and characterization of rice bran extract encapsulated in solid lipid nanoparticles for dermal delivery",

abstract = "Solid lipid nanoparticles (SLNs) recently gain attention as colloidal drug carriers, for both intravenous and dermal delivery. The present study focused on the preparation and some characterization of SLN associated with gamma-oryzanol of the specialized delivery systems. The nanoparticles, containing Dynasan 114 as lipid and Pluronic{\textregistered} F68 as emulsifying agent were prepared by hot homogenization method. Particle sizes of SLNs were in suitable range and homogenous. Moreover, SLNs containing gamma-oryzanol are stable for investigated time as suggested by size, pH, \% entrapment efficiency and DSC. Moreover, HPLC chromatograms indicated that no degradation was observed within the investigated period. Therefore chosen composition and method of preparation benefit the stability of the nanoparticles, which is suitable for transdermal skin penetration.",

keywords = "Drug delivery, Gamma-oryzanol, Nanparticles, Solid lipid nanoparticles",

author = "Usawadee Sakulkhu and Sanitra Jarupaiboon and Alongkot Trithong and Sirapat Prathontep and Varaporn Janyaprasert and Satit Puttipipatkhachorn and Uracha Ruktanonchai",

year = "2007",

doi = "10.1109/NEMS.2007.352191",

language = "English",

isbn = "1424406102",

series = "Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007",

pages = "1020--1023",

booktitle = "Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007",

note = "2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 ; Conference date: 16-01-2007 Through 19-01-2007",

}

Sakulkhu, U, Jarupaiboon, S, Trithong, A, Prathontep, S, Janyaprasert, V, Puttipipatkhachorn, S & Ruktanonchai, U 2007, Production and characterization of rice bran extract encapsulated in solid lipid nanoparticles for dermal delivery. in Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007., 4160494, Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007, pp. 1020-1023, 2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007, Bangkok, Thailand, 16/01/07. https://doi.org/10.1109/NEMS.2007.352191

Production and characterization of rice bran extract encapsulated in solid lipid nanoparticles for dermal delivery. / Sakulkhu, Usawadee; Jarupaiboon, Sanitra; Trithong, Alongkot et al.
Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. p. 1020-1023 4160494 (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Production and characterization of rice bran extract encapsulated in solid lipid nanoparticles for dermal delivery

AU - Sakulkhu, Usawadee

AU - Jarupaiboon, Sanitra

AU - Trithong, Alongkot

AU - Prathontep, Sirapat

AU - Janyaprasert, Varaporn

AU - Puttipipatkhachorn, Satit

AU - Ruktanonchai, Uracha

PY - 2007

Y1 - 2007

N2 - Solid lipid nanoparticles (SLNs) recently gain attention as colloidal drug carriers, for both intravenous and dermal delivery. The present study focused on the preparation and some characterization of SLN associated with gamma-oryzanol of the specialized delivery systems. The nanoparticles, containing Dynasan 114 as lipid and Pluronic® F68 as emulsifying agent were prepared by hot homogenization method. Particle sizes of SLNs were in suitable range and homogenous. Moreover, SLNs containing gamma-oryzanol are stable for investigated time as suggested by size, pH, % entrapment efficiency and DSC. Moreover, HPLC chromatograms indicated that no degradation was observed within the investigated period. Therefore chosen composition and method of preparation benefit the stability of the nanoparticles, which is suitable for transdermal skin penetration.

AB - Solid lipid nanoparticles (SLNs) recently gain attention as colloidal drug carriers, for both intravenous and dermal delivery. The present study focused on the preparation and some characterization of SLN associated with gamma-oryzanol of the specialized delivery systems. The nanoparticles, containing Dynasan 114 as lipid and Pluronic® F68 as emulsifying agent were prepared by hot homogenization method. Particle sizes of SLNs were in suitable range and homogenous. Moreover, SLNs containing gamma-oryzanol are stable for investigated time as suggested by size, pH, % entrapment efficiency and DSC. Moreover, HPLC chromatograms indicated that no degradation was observed within the investigated period. Therefore chosen composition and method of preparation benefit the stability of the nanoparticles, which is suitable for transdermal skin penetration.

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KW - Gamma-oryzanol

KW - Nanparticles

KW - Solid lipid nanoparticles

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DO - 10.1109/NEMS.2007.352191

M3 - Conference contribution

AN - SCOPUS:34548129923

SN - 1424406102

SN - 9781424406104

T3 - Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

SP - 1020

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BT - Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

T2 - 2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

Y2 - 16 January 2007 through 19 January 2007

ER -

Sakulkhu U, Jarupaiboon S, Trithong A, Prathontep S, Janyaprasert V, Puttipipatkhachorn S et al. Production and characterization of rice bran extract encapsulated in solid lipid nanoparticles for dermal delivery. In Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. p. 1020-1023. 4160494. (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007). doi: 10.1109/NEMS.2007.352191

Production and characterization of rice bran extract encapsulated in solid lipid nanoparticles for dermal delivery

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