Preparation of core-stabilized polyion complex micelles entrapping enzymes as novel bionano-reactor system

A. Harada; A. Kawamura; M. Jaturanpinyo; X. Yuan; K. Kono; T. Takagishi; K. Kataoka

Preparation of core-stabilized polyion complex micelles entrapping enzymes as novel bionano-reactor system

A. Harada
, A. Kawamura
, M. Jaturanpinyo
, X. Yuan
, K. Kono
, T. Takagishi
, K. Kataoka

Osaka Prefecture University
University of Tokyo

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The preparation of core-stabilized polyion complex (PIC) micelles entrapping enzymes was investigated. The PIC micelles were prepared from the anionic block copolymer, polyethylene glycol (PEG-P) and a cationic enzyme, bovine pancreas trypsin by cross linking with glutaraldehyde through the Schiff base formation. The stability of PIC micelles entrapping enzymes was found to be improved by introducing cross-linking in the core with glutaraldehyde. The results provided a concept in the design of bionano-reactor potentially useful as protein delivery systems.

Original language	English
Title of host publication	Transactions - 7th World Biomaterials Congress
Pages	1749
Number of pages	1
Publication status	Published - 2004
Externally published	Yes
Event	Transactions - 7th World Biomaterials Congress - Sydney, Australia Duration: 17 May 2004 → 21 May 2004

Publication series

Name	Transactions - 7th World Biomaterials Congress

Conference

Conference	Transactions - 7th World Biomaterials Congress
Country/Territory	Australia
City	Sydney
Period	17/05/04 → 21/05/04

Cite this

@inproceedings{f0f4f79442884b06a6ed5d6911c5578c,

title = "Preparation of core-stabilized polyion complex micelles entrapping enzymes as novel bionano-reactor system",

abstract = "The preparation of core-stabilized polyion complex (PIC) micelles entrapping enzymes was investigated. The PIC micelles were prepared from the anionic block copolymer, polyethylene glycol (PEG-P) and a cationic enzyme, bovine pancreas trypsin by cross linking with glutaraldehyde through the Schiff base formation. The stability of PIC micelles entrapping enzymes was found to be improved by introducing cross-linking in the core with glutaraldehyde. The results provided a concept in the design of bionano-reactor potentially useful as protein delivery systems.",

author = "A. Harada and A. Kawamura and M. Jaturanpinyo and X. Yuan and K. Kono and T. Takagishi and K. Kataoka",

year = "2004",

language = "English",

isbn = "1877040193",

series = "Transactions - 7th World Biomaterials Congress",

pages = "1749",

booktitle = "Transactions - 7th World Biomaterials Congress",

note = "Transactions - 7th World Biomaterials Congress ; Conference date: 17-05-2004 Through 21-05-2004",

}

Harada, A, Kawamura, A, Jaturanpinyo, M, Yuan, X, Kono, K, Takagishi, T & Kataoka, K 2004, Preparation of core-stabilized polyion complex micelles entrapping enzymes as novel bionano-reactor system. in Transactions - 7th World Biomaterials Congress. Transactions - 7th World Biomaterials Congress, pp. 1749, Transactions - 7th World Biomaterials Congress, Sydney, Australia, 17/05/04.

Preparation of core-stabilized polyion complex micelles entrapping enzymes as novel bionano-reactor system. / Harada, A.; Kawamura, A.; Jaturanpinyo, M. et al.
Transactions - 7th World Biomaterials Congress. 2004. p. 1749 (Transactions - 7th World Biomaterials Congress).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Preparation of core-stabilized polyion complex micelles entrapping enzymes as novel bionano-reactor system

AU - Harada, A.

AU - Kawamura, A.

AU - Jaturanpinyo, M.

AU - Yuan, X.

AU - Kono, K.

AU - Takagishi, T.

AU - Kataoka, K.

PY - 2004

Y1 - 2004

N2 - The preparation of core-stabilized polyion complex (PIC) micelles entrapping enzymes was investigated. The PIC micelles were prepared from the anionic block copolymer, polyethylene glycol (PEG-P) and a cationic enzyme, bovine pancreas trypsin by cross linking with glutaraldehyde through the Schiff base formation. The stability of PIC micelles entrapping enzymes was found to be improved by introducing cross-linking in the core with glutaraldehyde. The results provided a concept in the design of bionano-reactor potentially useful as protein delivery systems.

AB - The preparation of core-stabilized polyion complex (PIC) micelles entrapping enzymes was investigated. The PIC micelles were prepared from the anionic block copolymer, polyethylene glycol (PEG-P) and a cationic enzyme, bovine pancreas trypsin by cross linking with glutaraldehyde through the Schiff base formation. The stability of PIC micelles entrapping enzymes was found to be improved by introducing cross-linking in the core with glutaraldehyde. The results provided a concept in the design of bionano-reactor potentially useful as protein delivery systems.

UR - https://www.scopus.com/pages/publications/13844267059

M3 - Conference contribution

AN - SCOPUS:13844267059

SN - 1877040193

SN - 9781877040191

T3 - Transactions - 7th World Biomaterials Congress

SP - 1749

BT - Transactions - 7th World Biomaterials Congress

T2 - Transactions - 7th World Biomaterials Congress

Y2 - 17 May 2004 through 21 May 2004

ER -

Preparation of core-stabilized polyion complex micelles entrapping enzymes as novel bionano-reactor system

Abstract

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Conference

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