Polymeric disinfectant nanocapsules: Effect of molecular weight of poly(methyl acrylate)

Saovaree Tanpantree; Pakorn Opaprakasit; Duangporn Polpanich; Srung Smanmoo; Pramuan Tangboriboonrat

doi:10.1166/jbn.2010.1134

Polymeric disinfectant nanocapsules: Effect of molecular weight of poly(methyl acrylate)

Saovaree Tanpantree
, Pakorn Opaprakasit
, Duangporn Polpanich
, Srung Smanmoo
, Pramuan Tangboriboonrat

Mahidol University
Sirindhorn International Institute of Technology, Thammasat University
National Science and Technology Development Agency (NSTDA)

Research output: Contribution to journal › Article › peer-review

Abstract

Poly(methyl acrylate) (PMA) of various weight average molecular weights (M̄_w) were synthesized via the iniferter route and applied for the encapsulation of disinfectant agent (chlorhexidine digluconate; CHD) by using the controlled precipitation technique. The encapsulation efficiency of CHD-PMA nanocapsules suspended in cyclohexane increased from 70 to 100% when the M̄_w of PMA increased from 40 K to 550 K. After redispersing the capsules into 0.5% w/v of sodium dodecyl sulphate aqueous solution, the maximum content of CHD in the nanocapsules remained >90%. Transmission electron micrographs showed the spherical nanocapsule with continuous intact shell.

Original language	English
Pages (from-to)	385-390
Number of pages	6
Journal	Journal of Biomedical Nanotechnology
Volume	6
Issue number	4
DOIs	https://doi.org/10.1166/jbn.2010.1134
Publication status	Published - Aug 2010
Externally published	Yes

Keywords

Disinfectant agent
Iniferter
Nanocapsule
Nanoparticle

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10.1166/jbn.2010.1134

Cite this

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title = "Polymeric disinfectant nanocapsules: Effect of molecular weight of poly(methyl acrylate)",

abstract = "Poly(methyl acrylate) (PMA) of various weight average molecular weights ({\=M}w) were synthesized via the iniferter route and applied for the encapsulation of disinfectant agent (chlorhexidine digluconate; CHD) by using the controlled precipitation technique. The encapsulation efficiency of CHD-PMA nanocapsules suspended in cyclohexane increased from 70 to 100\% when the {\=M}w of PMA increased from 40 K to 550 K. After redispersing the capsules into 0.5\% w/v of sodium dodecyl sulphate aqueous solution, the maximum content of CHD in the nanocapsules remained >90\%. Transmission electron micrographs showed the spherical nanocapsule with continuous intact shell.",

keywords = "Disinfectant agent, Iniferter, Nanocapsule, Nanoparticle",

author = "Saovaree Tanpantree and Pakorn Opaprakasit and Duangporn Polpanich and Srung Smanmoo and Pramuan Tangboriboonrat",

year = "2010",

month = aug,

doi = "10.1166/jbn.2010.1134",

language = "English",

volume = "6",

pages = "385--390",

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TY - JOUR

T1 - Polymeric disinfectant nanocapsules

T2 - Effect of molecular weight of poly(methyl acrylate)

AU - Tanpantree, Saovaree

AU - Opaprakasit, Pakorn

AU - Polpanich, Duangporn

AU - Smanmoo, Srung

AU - Tangboriboonrat, Pramuan

PY - 2010/8

Y1 - 2010/8

N2 - Poly(methyl acrylate) (PMA) of various weight average molecular weights (M̄w) were synthesized via the iniferter route and applied for the encapsulation of disinfectant agent (chlorhexidine digluconate; CHD) by using the controlled precipitation technique. The encapsulation efficiency of CHD-PMA nanocapsules suspended in cyclohexane increased from 70 to 100% when the M̄w of PMA increased from 40 K to 550 K. After redispersing the capsules into 0.5% w/v of sodium dodecyl sulphate aqueous solution, the maximum content of CHD in the nanocapsules remained >90%. Transmission electron micrographs showed the spherical nanocapsule with continuous intact shell.

AB - Poly(methyl acrylate) (PMA) of various weight average molecular weights (M̄w) were synthesized via the iniferter route and applied for the encapsulation of disinfectant agent (chlorhexidine digluconate; CHD) by using the controlled precipitation technique. The encapsulation efficiency of CHD-PMA nanocapsules suspended in cyclohexane increased from 70 to 100% when the M̄w of PMA increased from 40 K to 550 K. After redispersing the capsules into 0.5% w/v of sodium dodecyl sulphate aqueous solution, the maximum content of CHD in the nanocapsules remained >90%. Transmission electron micrographs showed the spherical nanocapsule with continuous intact shell.

KW - Disinfectant agent

KW - Iniferter

KW - Nanocapsule

KW - Nanoparticle

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DO - 10.1166/jbn.2010.1134

M3 - Article

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AN - SCOPUS:79953012455

SN - 1550-7033

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SP - 385

EP - 390

JO - Journal of Biomedical Nanotechnology

JF - Journal of Biomedical Nanotechnology

IS - 4

ER -

Polymeric disinfectant nanocapsules: Effect of molecular weight of poly(methyl acrylate)

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Keywords

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