TY - GEN
T1 - Pharmacokinetic simulation for prediction of drug-drug interactions based on agent based modeling
AU - Hunta, Sathien
AU - Longpradit, Panchit
N1 - Publisher Copyright:
© 2018 IEEE.
PY - 2018/6/8
Y1 - 2018/6/8
N2 - Drug-Drug Interactions (DDI) is a cause of treatment inefficacy and toxicity. Many DDIs are caused by alterations in drug metabolism that related to drug-enzyme actions. Drugs can be substrate, inhibitor or inducer of enzymes which interfere their metabolism. Therefore, this paper proposes a method for simulating the DDI using agent based modeling (ABM). The study consists of three steps: data gathering, drug-enzyme action pairing and ABM generation. The ABM application was developed, allows user to adjust drug concentration, reaction rate parameters, and add others drugs to the system environment. To demonstrate the ABM application, the enzyme reaction of DDI example (simvastatin and amiodarone) was simulated. Simulation results demonstrate that the model could be an effective method to do the DDI simulation without the setting of the real experiment.
AB - Drug-Drug Interactions (DDI) is a cause of treatment inefficacy and toxicity. Many DDIs are caused by alterations in drug metabolism that related to drug-enzyme actions. Drugs can be substrate, inhibitor or inducer of enzymes which interfere their metabolism. Therefore, this paper proposes a method for simulating the DDI using agent based modeling (ABM). The study consists of three steps: data gathering, drug-enzyme action pairing and ABM generation. The ABM application was developed, allows user to adjust drug concentration, reaction rate parameters, and add others drugs to the system environment. To demonstrate the ABM application, the enzyme reaction of DDI example (simvastatin and amiodarone) was simulated. Simulation results demonstrate that the model could be an effective method to do the DDI simulation without the setting of the real experiment.
UR - https://www.scopus.com/pages/publications/85049893780
U2 - 10.1109/ICDAMT.2018.8376508
DO - 10.1109/ICDAMT.2018.8376508
M3 - Conference contribution
AN - SCOPUS:85049893780
T3 - 3rd International Conference on Digital Arts, Media and Technology, ICDAMT 2018
SP - 126
EP - 129
BT - 3rd International Conference on Digital Arts, Media and Technology, ICDAMT 2018
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 3rd International Conference on Digital Arts, Media and Technology, ICDAMT 2018
Y2 - 25 February 2018 through 28 February 2018
ER -