TY - GEN
T1 - Palm-sized magnetofluidic platform for bacterial identification and antimicrobial susceptibility testing of infected wounds
AU - Lee, Pei Wei
AU - Chen, Liben
AU - Trick, Alexander Y.
AU - Athamanolap, Pornpat
AU - Chen, Fan En
AU - Wang, Tza Huei
N1 - Publisher Copyright:
© 2019 CBMS-0001.
PY - 2019
Y1 - 2019
N2 - Evidence-based clinical practice can reduce antibiotic resistance caused by empirical therapy. To this end, diagnostics methods that can quickly provide results of both bacterial identification and bacterial antimicrobial susceptibility are highly desired. Here, we present a palm-sized device that can identify bacteria and simultaneously test their antibiotic susceptibility from infected wounds. The device couples magnetofluidic technology for DNA extraction and purification, with the high-resolution melt for bacterial identification. Using our device, we have been able to identify 7 common wound pathogens and to simultaneously perform the antimicrobial susceptibility tests. The results can be delivered within 2.5 hours.
AB - Evidence-based clinical practice can reduce antibiotic resistance caused by empirical therapy. To this end, diagnostics methods that can quickly provide results of both bacterial identification and bacterial antimicrobial susceptibility are highly desired. Here, we present a palm-sized device that can identify bacteria and simultaneously test their antibiotic susceptibility from infected wounds. The device couples magnetofluidic technology for DNA extraction and purification, with the high-resolution melt for bacterial identification. Using our device, we have been able to identify 7 common wound pathogens and to simultaneously perform the antimicrobial susceptibility tests. The results can be delivered within 2.5 hours.
KW - Antimicrobial susceptibility testing
KW - Bacterial identification
KW - Magnetfluidic
KW - Wound
UR - https://www.scopus.com/pages/publications/85094979843
M3 - Conference contribution
AN - SCOPUS:85094979843
T3 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
SP - 858
EP - 859
BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PB - Chemical and Biological Microsystems Society
T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Y2 - 27 October 2019 through 31 October 2019
ER -