Optimal cutoff titers for indirect immunofluorescence assay for diagnosis of scrub typhus

Cherry Lim; Stuart D. Blacksell; Achara Laongnualpanich; Pacharee Kantipong; Nicholas P.J. Day; Daniel H. Paris; Direk Limmathurotsakul

doi:10.1128/JCM.01680-15

Optimal cutoff titers for indirect immunofluorescence assay for diagnosis of scrub typhus

Cherry Lim
, Stuart D. Blacksell
, Achara Laongnualpanich
, Pacharee Kantipong
, Nicholas P.J. Day
, Daniel H. Paris
, Direk Limmathurotsakul

Department of Tropical Hygiene

Mahidol University
Nuffield Department of Medicine
Chiangrai Prachanukroh Hospital

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

We determined the optimal cutoff titers in admission and convalescent-phase samples for scrub typhus indirect immunofluorescence assay using Bayesian latent class models. Cutoff titers of>1:3,200 in an admission sample or of a>4-fold rise to>1:3,200 in a convalescent-phase sample provided the highest accuracy (sensitivity, 81.6%; specificity, 100%).

Original language	English
Pages (from-to)	3663-3666
Number of pages	4
Journal	Journal of Clinical Microbiology
Volume	53
Issue number	11
DOIs	https://doi.org/10.1128/JCM.01680-15
Publication status	Published - Nov 2015

Access to Document

10.1128/JCM.01680-15

Cite this

@article{fcedf54d70f54ccb8aef66424c6ef0d4,

title = "Optimal cutoff titers for indirect immunofluorescence assay for diagnosis of scrub typhus",

abstract = "We determined the optimal cutoff titers in admission and convalescent-phase samples for scrub typhus indirect immunofluorescence assay using Bayesian latent class models. Cutoff titers of>1:3,200 in an admission sample or of a>4-fold rise to>1:3,200 in a convalescent-phase sample provided the highest accuracy (sensitivity, 81.6\%; specificity, 100\%).",

author = "Cherry Lim and Blacksell, \{Stuart D.\} and Achara Laongnualpanich and Pacharee Kantipong and Day, \{Nicholas P.J.\} and Paris, \{Daniel H.\} and Direk Limmathurotsakul",

year = "2015",

month = nov,

doi = "10.1128/JCM.01680-15",

language = "English",

volume = "53",

pages = "3663--3666",

journal = "Journal of Clinical Microbiology",

issn = "0095-1137",

publisher = "American Society for Microbiology",

number = "11",

}

TY - JOUR

T1 - Optimal cutoff titers for indirect immunofluorescence assay for diagnosis of scrub typhus

AU - Lim, Cherry

AU - Blacksell, Stuart D.

AU - Laongnualpanich, Achara

AU - Kantipong, Pacharee

AU - Day, Nicholas P.J.

AU - Paris, Daniel H.

AU - Limmathurotsakul, Direk

PY - 2015/11

Y1 - 2015/11

N2 - We determined the optimal cutoff titers in admission and convalescent-phase samples for scrub typhus indirect immunofluorescence assay using Bayesian latent class models. Cutoff titers of>1:3,200 in an admission sample or of a>4-fold rise to>1:3,200 in a convalescent-phase sample provided the highest accuracy (sensitivity, 81.6%; specificity, 100%).

AB - We determined the optimal cutoff titers in admission and convalescent-phase samples for scrub typhus indirect immunofluorescence assay using Bayesian latent class models. Cutoff titers of>1:3,200 in an admission sample or of a>4-fold rise to>1:3,200 in a convalescent-phase sample provided the highest accuracy (sensitivity, 81.6%; specificity, 100%).

UR - https://www.scopus.com/pages/publications/84945241907

U2 - 10.1128/JCM.01680-15

DO - 10.1128/JCM.01680-15

M3 - Article

C2 - 26354819

AN - SCOPUS:84945241907

SN - 0095-1137

VL - 53

SP - 3663

EP - 3666

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 11

ER -

Optimal cutoff titers for indirect immunofluorescence assay for diagnosis of scrub typhus

Abstract

Access to Document

Other files and links

Fingerprint

Cite this