TY - GEN
T1 - Novel Protein-Protein Interaction Network of Antipsychotic Drugs and Cognitive Function
AU - Thanontip, Kamonwan
AU - Chetsawang, Banthit
AU - Chumchua, Vasunun
N1 - Publisher Copyright:
© 2019 IEEE.
PY - 2019/11
Y1 - 2019/11
N2 - Cognitive function is the intellectual activity of mental processes, such as, attention, processing speed, learning and memory, executive function, verbal fluency, and working memory. Cognitive deficits may contribute to functional disability in psychiatric disorders. Therefore, improving cognitive function has the potential to enhance the quality of life and occupational capacity, and reduce disease problems and societal costs. Recent evidence emphasized that conventional antipsychotics effective in treating positive symptoms but have almost no therapeutic benefit on cognitive impairment and produce a poor functional outcome. It has been hypothesized that antipsychotics might induce cognitive impairment or decline in psychiatric disorders. Therefore, this study aims to elucidate the network of proteins that may involve in antipsychotic drug-induced cognitive impairment. The results of GeneCards analysis showed 213 target genes of commonly use antipsychotics in schizophrenia, 122 genes associated with cognitive function in schizophrenia, and 28 genes related to antipsychotics and cognitive function in schizophrenia. Protein-protein interaction (PPI) network of 12 significantly interconnected proteins was generated by the PPI network analysis and clustering method. The 16 significant pathways related to antipsychotic drugs and cognitive function were identified using pathway grouped network analysis. These results demonstrate clue evidence to discover novel target sites of action of antipsychotics that might play a pivotal role in cognitive deficits in schizophrenia.
AB - Cognitive function is the intellectual activity of mental processes, such as, attention, processing speed, learning and memory, executive function, verbal fluency, and working memory. Cognitive deficits may contribute to functional disability in psychiatric disorders. Therefore, improving cognitive function has the potential to enhance the quality of life and occupational capacity, and reduce disease problems and societal costs. Recent evidence emphasized that conventional antipsychotics effective in treating positive symptoms but have almost no therapeutic benefit on cognitive impairment and produce a poor functional outcome. It has been hypothesized that antipsychotics might induce cognitive impairment or decline in psychiatric disorders. Therefore, this study aims to elucidate the network of proteins that may involve in antipsychotic drug-induced cognitive impairment. The results of GeneCards analysis showed 213 target genes of commonly use antipsychotics in schizophrenia, 122 genes associated with cognitive function in schizophrenia, and 28 genes related to antipsychotics and cognitive function in schizophrenia. Protein-protein interaction (PPI) network of 12 significantly interconnected proteins was generated by the PPI network analysis and clustering method. The 16 significant pathways related to antipsychotic drugs and cognitive function were identified using pathway grouped network analysis. These results demonstrate clue evidence to discover novel target sites of action of antipsychotics that might play a pivotal role in cognitive deficits in schizophrenia.
KW - antipsychotics
KW - cognitive function
KW - network analysis
KW - schizophrenia
UR - https://www.scopus.com/pages/publications/85080029970
U2 - 10.1109/BMEiCON47515.2019.8990302
DO - 10.1109/BMEiCON47515.2019.8990302
M3 - Conference contribution
AN - SCOPUS:85080029970
T3 - BMEiCON 2019 - 12th Biomedical Engineering International Conference
BT - BMEiCON 2019 - 12th Biomedical Engineering International Conference
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 12th Biomedical Engineering International Conference, BMEiCON 2019
Y2 - 19 November 2019 through 22 November 2019
ER -