Novel denisovan and neanderthal retroviruses

Adam Lee; Derek Huntley; Pakorn Aiewsakun; Ravinder K. Kanda; Claire Lynn; Michael Tristem

doi:10.1128/JVI.01825-14

Novel denisovan and neanderthal retroviruses

Adam Lee
, Derek Huntley
, Pakorn Aiewsakun
, Ravinder K. Kanda
, Claire Lynn
, Michael Tristem

Imperial College London
Oxford University Clinical Academic Graduate School

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Following the recent availability of high-coverage genomes for Denisovan and Neanderthal hominids, we conducted a screen for endogenized retroviruses, identifying six novel, previously unreported HERV-K(HML2) elements (HERV-K is human endogenous retrovirus K). These elements are absent from the human genome (hg38) and appear to be unique to archaic hominids. These findings provide further evidence supporting the recent activity of the HERV-K(HML2) group, which has been implicated in human disease. They will also provide insights into the evolution of archaic hominids.

Original language	English
Pages (from-to)	12907-12909
Number of pages	3
Journal	Journal of Virology
Volume	88
Issue number	21
DOIs	https://doi.org/10.1128/JVI.01825-14
Publication status	Published - 2014
Externally published	Yes

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title = "Novel denisovan and neanderthal retroviruses",

abstract = "Following the recent availability of high-coverage genomes for Denisovan and Neanderthal hominids, we conducted a screen for endogenized retroviruses, identifying six novel, previously unreported HERV-K(HML2) elements (HERV-K is human endogenous retrovirus K). These elements are absent from the human genome (hg38) and appear to be unique to archaic hominids. These findings provide further evidence supporting the recent activity of the HERV-K(HML2) group, which has been implicated in human disease. They will also provide insights into the evolution of archaic hominids.",

author = "Adam Lee and Derek Huntley and Pakorn Aiewsakun and Kanda, \{Ravinder K.\} and Claire Lynn and Michael Tristem",

note = "Publisher Copyright: {\textcopyright} 2014, American Society for Microbiology.",

year = "2014",

doi = "10.1128/JVI.01825-14",

language = "English",

volume = "88",

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T1 - Novel denisovan and neanderthal retroviruses

AU - Lee, Adam

AU - Huntley, Derek

AU - Aiewsakun, Pakorn

AU - Kanda, Ravinder K.

AU - Lynn, Claire

AU - Tristem, Michael

PY - 2014

Y1 - 2014

N2 - Following the recent availability of high-coverage genomes for Denisovan and Neanderthal hominids, we conducted a screen for endogenized retroviruses, identifying six novel, previously unreported HERV-K(HML2) elements (HERV-K is human endogenous retrovirus K). These elements are absent from the human genome (hg38) and appear to be unique to archaic hominids. These findings provide further evidence supporting the recent activity of the HERV-K(HML2) group, which has been implicated in human disease. They will also provide insights into the evolution of archaic hominids.

AB - Following the recent availability of high-coverage genomes for Denisovan and Neanderthal hominids, we conducted a screen for endogenized retroviruses, identifying six novel, previously unreported HERV-K(HML2) elements (HERV-K is human endogenous retrovirus K). These elements are absent from the human genome (hg38) and appear to be unique to archaic hominids. These findings provide further evidence supporting the recent activity of the HERV-K(HML2) group, which has been implicated in human disease. They will also provide insights into the evolution of archaic hominids.

UR - https://www.scopus.com/pages/publications/84908010616

U2 - 10.1128/JVI.01825-14

DO - 10.1128/JVI.01825-14

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VL - 88

SP - 12907

EP - 12909

JO - Journal of Virology

JF - Journal of Virology

IS - 21

ER -

Novel denisovan and neanderthal retroviruses

Abstract

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