Abstract
Two new compounds, nanaomycin F and G, were isolated by physicochemical screening method from cultured broth of Streptomyces rosa subsp. notoensis OS-3966, which is known to produce nanaomycin A, B, C, D, and E. Nanaomycin F is a new nanaomycin analog, a 4a-hydroxyl analog of nanaomycin B. Nanaomycin G has a unique skeleton with 1-indanone infused with a tetrahydropyran ring. Nanaomycin A possesses broad antimicrobial activity but nanaomycin F and G demonstrated no bioactivity against all bacteria and fungi tested in this study. In addition, in both nanaomycin F and G, the production of superoxide radicals was majorly decreased in comparison to nanaomycin A. It was considered that the antimicrobial properties were lost as a result of the decrease in production of the superoxide radicals.
| Original language | English |
|---|---|
| Pages (from-to) | 596-600 |
| Number of pages | 5 |
| Journal | Journal of Bioscience and Bioengineering |
| Volume | 120 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Nov 2015 |
Keywords
- Nanaomycin F
- Nanaomycin G
- Nanaomycin analogs
- Physicochemical screening
- Streptomyces sp.
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