Mucosal-Associated Lymphoid Tissue Lymphoma in Southeast Asia: A 15-Year Retrospective Multicenter Study

Kannadit Prayongratana; Tanapun Thamgrang; Chonlada Laoruangroj; Lalita Norasetthada; Thanawat Rattanathammethee; Udomsak Bunworasate; Kitsada Wudhikarn; Jakrawadee Julamanee; Panarat Noiperm; Suporn Chuncharunee; Pimjai Niparuck; Archrob Khuhapinant; Noppadol Siritanaratkul; Piyapong Kanya; Kanchana Chansung; Chittima Sirijerachai; Dusit Jit-Uaekul; Juthatip Chaloemwong; Nonglak Kanitsap; Peerapon Wong; Nisa Makruasi; Somchai Wongkhantee; Tawatchai Suwanban; Tanin Intragumtornchai

doi:10.3390/hematolrep17060063

Mucosal-Associated Lymphoid Tissue Lymphoma in Southeast Asia: A 15-Year Retrospective Multicenter Study

Kannadit Prayongratana
, Tanapun Thamgrang
, Chonlada Laoruangroj
, Lalita Norasetthada
, Thanawat Rattanathammethee
, Udomsak Bunworasate
, Kitsada Wudhikarn
, Jakrawadee Julamanee
, Panarat Noiperm
, Suporn Chuncharunee
, Pimjai Niparuck
, Archrob Khuhapinant
, Noppadol Siritanaratkul
, Piyapong Kanya
, Kanchana Chansung
, Chittima Sirijerachai
, Dusit Jit-Uaekul
, Juthatip Chaloemwong
, Nonglak Kanitsap
, Peerapon Wong

Nisa Makruasi, Somchai Wongkhantee, Tawatchai Suwanban, Tanin Intragumtornchai

Phramongkutklao Hospital
Faculty of Medicine, Chiang Mai University
Faculty of Medicine, Chulalongkorn University
Faculty of Medicine, Prince of Songkla University
Ramathibodi Hospital
Siriraj Hospital
Division of Hematology
Khon Kaen University
Vajira Hospital
Nakornping Hospital
Faculty of Medicine, Thammasat University
Naresuan University
Srinakharinwirot University
Khon Kaen Regional Hospital
Rajavithi Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To describe the epidemiology, survival rate, and prognostic factors of mucosal-associated lymphoid tissue (MALT) lymphoma. Patients and Methods: This investigation utilized the Thai Lymphoma Study Group (TLSG) registry to gather data on patients diagnosed with MALT lymphoma. The analysis included demographic details, therapeutic interventions, and survival statistics. Results: The TLSG registry prospectively included 8404 patients with lymphoma. Among them, marginal-zone lymphoma (MZL) was the second most common subtype, with 670 histologically confirmed cases, accounting for 8.0% of the total cohort. An analysis of the MZL subtypes showed that MALT lymphoma was the most common, accounting for 77.8% of the diagnoses. This was followed by nodal MZL at 17.5% and splenic MZL at 7.7%. The distribution of primary disease sites indicated that the ocular adnexa (49.2%), stomach (12.9%), and sinonasal region (12.5%) were the three most common locations. Three variables were found to be statistically significant predictors of survival in the multivariate analysis: ECOG performance status > 2, age exceeding 65 years, and involvement of more than two extranodal organs. These identified prognostic factors were further assessed for their effect on overall survival (OS) and progression-free survival (PFS). A risk classification was established: the low-risk group comprised patients with zero identified risk factors, whereas the high-risk group included patients who had any of the specified risk factors. A comparison of five-year survival rates showed significantly more favorable outcomes for low-risk patients who had a PFS of 83.3% (vs. 66.1%, p = 0.028) and an OS of 97.8% (vs. 76.7%, p < 0.001) compared to the high-risk group. Conclusions: In this cohort, where MZL was the second most common lymphoma and MALT lymphoma was the predominant subtype, our analysis revealed that patients with no risk factors experienced statistically significant improvements in both PFS and OS.

Original language	English
Article number	63
Journal	Hematology Reports
Volume	17
Issue number	6
DOIs	https://doi.org/10.3390/hematolrep17060063
Publication status	Published - Dec 2025

Keywords

MALT lymphoma
extranodal marginal-zone lymphoma
marginal-zone lymphoma
mucosal-associated lymphoid tissue lymphoma

Access to Document

10.3390/hematolrep17060063

Cite this

Prayongratana, K., Thamgrang, T., Laoruangroj, C., Norasetthada, L., Rattanathammethee, T., Bunworasate, U., Wudhikarn, K., Julamanee, J., Noiperm, P., Chuncharunee, S., Niparuck, P., Khuhapinant, A., Siritanaratkul, N., Kanya, P., Chansung, K., Sirijerachai, C., Jit-Uaekul, D., Chaloemwong, J., Kanitsap, N., ... Intragumtornchai, T. (2025). Mucosal-Associated Lymphoid Tissue Lymphoma in Southeast Asia: A 15-Year Retrospective Multicenter Study. Hematology Reports, 17(6), Article 63. https://doi.org/10.3390/hematolrep17060063

@article{7a33292dc4d04f13aff27384fe00ccad,

title = "Mucosal-Associated Lymphoid Tissue Lymphoma in Southeast Asia: A 15-Year Retrospective Multicenter Study",

abstract = "Objective: To describe the epidemiology, survival rate, and prognostic factors of mucosal-associated lymphoid tissue (MALT) lymphoma. Patients and Methods: This investigation utilized the Thai Lymphoma Study Group (TLSG) registry to gather data on patients diagnosed with MALT lymphoma. The analysis included demographic details, therapeutic interventions, and survival statistics. Results: The TLSG registry prospectively included 8404 patients with lymphoma. Among them, marginal-zone lymphoma (MZL) was the second most common subtype, with 670 histologically confirmed cases, accounting for 8.0\% of the total cohort. An analysis of the MZL subtypes showed that MALT lymphoma was the most common, accounting for 77.8\% of the diagnoses. This was followed by nodal MZL at 17.5\% and splenic MZL at 7.7\%. The distribution of primary disease sites indicated that the ocular adnexa (49.2\%), stomach (12.9\%), and sinonasal region (12.5\%) were the three most common locations. Three variables were found to be statistically significant predictors of survival in the multivariate analysis: ECOG performance status > 2, age exceeding 65 years, and involvement of more than two extranodal organs. These identified prognostic factors were further assessed for their effect on overall survival (OS) and progression-free survival (PFS). A risk classification was established: the low-risk group comprised patients with zero identified risk factors, whereas the high-risk group included patients who had any of the specified risk factors. A comparison of five-year survival rates showed significantly more favorable outcomes for low-risk patients who had a PFS of 83.3\% (vs. 66.1\%, p = 0.028) and an OS of 97.8\% (vs. 76.7\%, p < 0.001) compared to the high-risk group. Conclusions: In this cohort, where MZL was the second most common lymphoma and MALT lymphoma was the predominant subtype, our analysis revealed that patients with no risk factors experienced statistically significant improvements in both PFS and OS.",

keywords = "MALT lymphoma, extranodal marginal-zone lymphoma, marginal-zone lymphoma, mucosal-associated lymphoid tissue lymphoma",

author = "Kannadit Prayongratana and Tanapun Thamgrang and Chonlada Laoruangroj and Lalita Norasetthada and Thanawat Rattanathammethee and Udomsak Bunworasate and Kitsada Wudhikarn and Jakrawadee Julamanee and Panarat Noiperm and Suporn Chuncharunee and Pimjai Niparuck and Archrob Khuhapinant and Noppadol Siritanaratkul and Piyapong Kanya and Kanchana Chansung and Chittima Sirijerachai and Dusit Jit-Uaekul and Juthatip Chaloemwong and Nonglak Kanitsap and Peerapon Wong and Nisa Makruasi and Somchai Wongkhantee and Tawatchai Suwanban and Tanin Intragumtornchai",

note = "Publisher Copyright: {\textcopyright} 2025 by the authors.",

year = "2025",

month = dec,

doi = "10.3390/hematolrep17060063",

language = "English",

volume = "17",

journal = "Hematology Reports",

issn = "2038-8322",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "6",

}

Prayongratana, K, Thamgrang, T, Laoruangroj, C, Norasetthada, L, Rattanathammethee, T, Bunworasate, U, Wudhikarn, K, Julamanee, J, Noiperm, P, Chuncharunee, S, Niparuck, P , Khuhapinant, A, Siritanaratkul, N, Kanya, P, Chansung, K, Sirijerachai, C, Jit-Uaekul, D, Chaloemwong, J, Kanitsap, N, Wong, P, Makruasi, N, Wongkhantee, S, Suwanban, T & Intragumtornchai, T 2025, 'Mucosal-Associated Lymphoid Tissue Lymphoma in Southeast Asia: A 15-Year Retrospective Multicenter Study', Hematology Reports, vol. 17, no. 6, 63. https://doi.org/10.3390/hematolrep17060063

TY - JOUR

T1 - Mucosal-Associated Lymphoid Tissue Lymphoma in Southeast Asia

T2 - A 15-Year Retrospective Multicenter Study

AU - Prayongratana, Kannadit

AU - Thamgrang, Tanapun

AU - Laoruangroj, Chonlada

AU - Norasetthada, Lalita

AU - Rattanathammethee, Thanawat

AU - Bunworasate, Udomsak

AU - Wudhikarn, Kitsada

AU - Julamanee, Jakrawadee

AU - Noiperm, Panarat

AU - Chuncharunee, Suporn

AU - Niparuck, Pimjai

AU - Khuhapinant, Archrob

AU - Siritanaratkul, Noppadol

AU - Kanya, Piyapong

AU - Chansung, Kanchana

AU - Sirijerachai, Chittima

AU - Jit-Uaekul, Dusit

AU - Chaloemwong, Juthatip

AU - Kanitsap, Nonglak

AU - Wong, Peerapon

AU - Makruasi, Nisa

AU - Wongkhantee, Somchai

AU - Suwanban, Tawatchai

AU - Intragumtornchai, Tanin

PY - 2025/12

Y1 - 2025/12

N2 - Objective: To describe the epidemiology, survival rate, and prognostic factors of mucosal-associated lymphoid tissue (MALT) lymphoma. Patients and Methods: This investigation utilized the Thai Lymphoma Study Group (TLSG) registry to gather data on patients diagnosed with MALT lymphoma. The analysis included demographic details, therapeutic interventions, and survival statistics. Results: The TLSG registry prospectively included 8404 patients with lymphoma. Among them, marginal-zone lymphoma (MZL) was the second most common subtype, with 670 histologically confirmed cases, accounting for 8.0% of the total cohort. An analysis of the MZL subtypes showed that MALT lymphoma was the most common, accounting for 77.8% of the diagnoses. This was followed by nodal MZL at 17.5% and splenic MZL at 7.7%. The distribution of primary disease sites indicated that the ocular adnexa (49.2%), stomach (12.9%), and sinonasal region (12.5%) were the three most common locations. Three variables were found to be statistically significant predictors of survival in the multivariate analysis: ECOG performance status > 2, age exceeding 65 years, and involvement of more than two extranodal organs. These identified prognostic factors were further assessed for their effect on overall survival (OS) and progression-free survival (PFS). A risk classification was established: the low-risk group comprised patients with zero identified risk factors, whereas the high-risk group included patients who had any of the specified risk factors. A comparison of five-year survival rates showed significantly more favorable outcomes for low-risk patients who had a PFS of 83.3% (vs. 66.1%, p = 0.028) and an OS of 97.8% (vs. 76.7%, p < 0.001) compared to the high-risk group. Conclusions: In this cohort, where MZL was the second most common lymphoma and MALT lymphoma was the predominant subtype, our analysis revealed that patients with no risk factors experienced statistically significant improvements in both PFS and OS.

AB - Objective: To describe the epidemiology, survival rate, and prognostic factors of mucosal-associated lymphoid tissue (MALT) lymphoma. Patients and Methods: This investigation utilized the Thai Lymphoma Study Group (TLSG) registry to gather data on patients diagnosed with MALT lymphoma. The analysis included demographic details, therapeutic interventions, and survival statistics. Results: The TLSG registry prospectively included 8404 patients with lymphoma. Among them, marginal-zone lymphoma (MZL) was the second most common subtype, with 670 histologically confirmed cases, accounting for 8.0% of the total cohort. An analysis of the MZL subtypes showed that MALT lymphoma was the most common, accounting for 77.8% of the diagnoses. This was followed by nodal MZL at 17.5% and splenic MZL at 7.7%. The distribution of primary disease sites indicated that the ocular adnexa (49.2%), stomach (12.9%), and sinonasal region (12.5%) were the three most common locations. Three variables were found to be statistically significant predictors of survival in the multivariate analysis: ECOG performance status > 2, age exceeding 65 years, and involvement of more than two extranodal organs. These identified prognostic factors were further assessed for their effect on overall survival (OS) and progression-free survival (PFS). A risk classification was established: the low-risk group comprised patients with zero identified risk factors, whereas the high-risk group included patients who had any of the specified risk factors. A comparison of five-year survival rates showed significantly more favorable outcomes for low-risk patients who had a PFS of 83.3% (vs. 66.1%, p = 0.028) and an OS of 97.8% (vs. 76.7%, p < 0.001) compared to the high-risk group. Conclusions: In this cohort, where MZL was the second most common lymphoma and MALT lymphoma was the predominant subtype, our analysis revealed that patients with no risk factors experienced statistically significant improvements in both PFS and OS.

KW - MALT lymphoma

KW - extranodal marginal-zone lymphoma

KW - marginal-zone lymphoma

KW - mucosal-associated lymphoid tissue lymphoma

UR - https://www.scopus.com/pages/publications/105025799204

U2 - 10.3390/hematolrep17060063

DO - 10.3390/hematolrep17060063

M3 - Article

AN - SCOPUS:105025799204

SN - 2038-8322

VL - 17

JO - Hematology Reports

JF - Hematology Reports

IS - 6

M1 - 63

ER -

Mucosal-Associated Lymphoid Tissue Lymphoma in Southeast Asia: A 15-Year Retrospective Multicenter Study

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this