Molecularly imprinted polymers for the extraction and determination of water-soluble vitamins: A review from 2001 to 2020

Molecularly imprinted polymers (MIPs) have been developed as alternative materials or artificial receptors to antibodies, with good memory as template molecules, and have received tremendous attention in various applications. MIPs have been applied for chemical and biological templates due to properties such as chemical and thermal stability, high specificity, high selectivity, reusability, and reproducibility. These attractive properties have resulted in MIPs being considered materials for template separation and determination in complex samples. Water-soluble vitamins are important compounds that are involved in many metabolic processes to maintain body homeostasis. Insufficiency/deficiency of these vitamins, especially in underdeveloped/developing countries, leads to many health problems. In this review, we present the progression of each water-soluble vitamin imprinted polymer in terms of MIP-based extraction, magnetic MIP-based extraction and MIP-based sensors from 2001 to 2020. Finally, challenges and future perspectives of MIPs in this field are discussed.