Molecular characterization of Pegarn: A Drosophila homolog of UNC-51 kinase

A. Ahantarig; L. V. Chadwell; I. B. Terrazas; C. T. Garcia; J. J. Nazarian; H. K. Lee; M. J. Lundell; J. A. Cassill

doi:10.1007/s11033-008-9314-4

Molecular characterization of Pegarn: A Drosophila homolog of UNC-51 kinase

A. Ahantarig
, L. V. Chadwell
, I. B. Terrazas
, C. T. Garcia
, J. J. Nazarian
, H. K. Lee
, M. J. Lundell
, J. A. Cassill

Mahidol University
University of Texas at San Antonio

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

We have isolated and characterized the gene encoding a Drosophila melanogaster homolog of Caenorhabditis elegans UNC-51 (uncoordinated movement-51): Pegarn. Developmental Northern blot shows the Pegarn gene is expressed at all stages of development. The protein is detected throughout the Drosophila third instar larval central nervous system (CNS) in axons projecting out from the ventral ganglion and in the optic anlagen of the optic lobe. Heterozygous Pegarn mutant embryos show defects in larval axonal neuronal patterning, but survive to adulthood. Homozygous mutants have an even more deformed pattern of neuronal development and do not survive through the larval stages. The data from this research suggest the critical roles of Pegarn in CNS and PNS axonal formation in Drosophila melanogaster and indicates its similar role in other multicellular species.

Original language	English
Pages (from-to)	1311-1321
Number of pages	11
Journal	Molecular Biology Reports
Volume	36
Issue number	6
DOIs	https://doi.org/10.1007/s11033-008-9314-4
Publication status	Published - Jul 2009
Externally published	Yes

Keywords

Central nervous system
Commissures
Connectives
Midlines
Uncoordinated movement-51
Ventral ganglion

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10.1007/s11033-008-9314-4

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title = "Molecular characterization of Pegarn: A Drosophila homolog of UNC-51 kinase",

abstract = "We have isolated and characterized the gene encoding a Drosophila melanogaster homolog of Caenorhabditis elegans UNC-51 (uncoordinated movement-51): Pegarn. Developmental Northern blot shows the Pegarn gene is expressed at all stages of development. The protein is detected throughout the Drosophila third instar larval central nervous system (CNS) in axons projecting out from the ventral ganglion and in the optic anlagen of the optic lobe. Heterozygous Pegarn mutant embryos show defects in larval axonal neuronal patterning, but survive to adulthood. Homozygous mutants have an even more deformed pattern of neuronal development and do not survive through the larval stages. The data from this research suggest the critical roles of Pegarn in CNS and PNS axonal formation in Drosophila melanogaster and indicates its similar role in other multicellular species.",

keywords = "Central nervous system, Commissures, Connectives, Midlines, Uncoordinated movement-51, Ventral ganglion",

author = "A. Ahantarig and Chadwell, \{L. V.\} and Terrazas, \{I. B.\} and Garcia, \{C. T.\} and Nazarian, \{J. J.\} and Lee, \{H. K.\} and Lundell, \{M. J.\} and Cassill, \{J. A.\}",

year = "2009",

month = jul,

doi = "10.1007/s11033-008-9314-4",

language = "English",

volume = "36",

pages = "1311--1321",

journal = "Molecular Biology Reports",

issn = "0301-4851",

publisher = "Springer Science and Business Media B.V.",

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TY - JOUR

T1 - Molecular characterization of Pegarn

T2 - A Drosophila homolog of UNC-51 kinase

AU - Ahantarig, A.

AU - Chadwell, L. V.

AU - Terrazas, I. B.

AU - Garcia, C. T.

AU - Nazarian, J. J.

AU - Lee, H. K.

AU - Lundell, M. J.

AU - Cassill, J. A.

PY - 2009/7

Y1 - 2009/7

N2 - We have isolated and characterized the gene encoding a Drosophila melanogaster homolog of Caenorhabditis elegans UNC-51 (uncoordinated movement-51): Pegarn. Developmental Northern blot shows the Pegarn gene is expressed at all stages of development. The protein is detected throughout the Drosophila third instar larval central nervous system (CNS) in axons projecting out from the ventral ganglion and in the optic anlagen of the optic lobe. Heterozygous Pegarn mutant embryos show defects in larval axonal neuronal patterning, but survive to adulthood. Homozygous mutants have an even more deformed pattern of neuronal development and do not survive through the larval stages. The data from this research suggest the critical roles of Pegarn in CNS and PNS axonal formation in Drosophila melanogaster and indicates its similar role in other multicellular species.

AB - We have isolated and characterized the gene encoding a Drosophila melanogaster homolog of Caenorhabditis elegans UNC-51 (uncoordinated movement-51): Pegarn. Developmental Northern blot shows the Pegarn gene is expressed at all stages of development. The protein is detected throughout the Drosophila third instar larval central nervous system (CNS) in axons projecting out from the ventral ganglion and in the optic anlagen of the optic lobe. Heterozygous Pegarn mutant embryos show defects in larval axonal neuronal patterning, but survive to adulthood. Homozygous mutants have an even more deformed pattern of neuronal development and do not survive through the larval stages. The data from this research suggest the critical roles of Pegarn in CNS and PNS axonal formation in Drosophila melanogaster and indicates its similar role in other multicellular species.

KW - Central nervous system

KW - Commissures

KW - Connectives

KW - Midlines

KW - Uncoordinated movement-51

KW - Ventral ganglion

UR - https://www.scopus.com/pages/publications/67651096073

U2 - 10.1007/s11033-008-9314-4

DO - 10.1007/s11033-008-9314-4

M3 - Article

C2 - 18636236

AN - SCOPUS:67651096073

SN - 0301-4851

VL - 36

SP - 1311

EP - 1321

JO - Molecular Biology Reports

JF - Molecular Biology Reports

IS - 6

ER -

Molecular characterization of Pegarn: A Drosophila homolog of UNC-51 kinase

Abstract

Keywords

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