Minimal Residual Disease Negativity Does Not Overcome Poor Prognosis in High-Risk Multiple Myeloma: A Single-Center Retrospective Study

Chutima Kunacheewa; Hans C. Lee; Krina Patel; Sheeba Thomas; Behrang Amini; Samer Srour; Qaiser Bashir; Yago Nieto; Muzzaffar H. Qazilbash; Donna M. Weber; Lei Feng; Robert Z. Orlowski; Pei Lin; Elisabet E. Manasanch

doi:10.1016/j.clml.2020.01.001

Minimal Residual Disease Negativity Does Not Overcome Poor Prognosis in High-Risk Multiple Myeloma: A Single-Center Retrospective Study

Chutima Kunacheewa
, Hans C. Lee
, Krina Patel
, Sheeba Thomas
, Behrang Amini
, Samer Srour
, Qaiser Bashir
, Yago Nieto
, Muzzaffar H. Qazilbash
, Donna M. Weber
, Lei Feng
, Robert Z. Orlowski
, Pei Lin
, Elisabet E. Manasanch

The University of Texas MD Anderson Cancer Center

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Patients with multiple myeloma (MM) who experience deep remissions, including minimal residual disease (MRD) negativity, have better clinical outcomes compared to those do not. We aimed to describe the effect of testing for MRD negativity in a cohort of MM patients outside of a clinical trial. For most patients, MRD negativity supports improved clinical outcomes. However, in our cohort of patients with high-risk MM, MRD negativity does not seem to affect the overall poor prognosis.

Original language	English
Pages (from-to)	e221-e238
Journal	Clinical Lymphoma, Myeloma and Leukemia
Volume	20
Issue number	5
DOIs	https://doi.org/10.1016/j.clml.2020.01.001
Publication status	Published - May 2020
Externally published	Yes

Keywords

Genetic risk
High-risk myeloma
Minimal residual disease
Newly diagnosed myeloma
Prognosis

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10.1016/j.clml.2020.01.001

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Kunacheewa, C., Lee, H. C., Patel, K., Thomas, S., Amini, B., Srour, S., Bashir, Q., Nieto, Y., Qazilbash, M. H., Weber, D. M., Feng, L., Orlowski, R. Z., Lin, P., & Manasanch, E. E. (2020). Minimal Residual Disease Negativity Does Not Overcome Poor Prognosis in High-Risk Multiple Myeloma: A Single-Center Retrospective Study. Clinical Lymphoma, Myeloma and Leukemia, 20(5), e221-e238. https://doi.org/10.1016/j.clml.2020.01.001

@article{b6c86bdd453a4fdea97f1cab4184f08c,

title = "Minimal Residual Disease Negativity Does Not Overcome Poor Prognosis in High-Risk Multiple Myeloma: A Single-Center Retrospective Study",

abstract = "Patients with multiple myeloma (MM) who experience deep remissions, including minimal residual disease (MRD) negativity, have better clinical outcomes compared to those do not. We aimed to describe the effect of testing for MRD negativity in a cohort of MM patients outside of a clinical trial. For most patients, MRD negativity supports improved clinical outcomes. However, in our cohort of patients with high-risk MM, MRD negativity does not seem to affect the overall poor prognosis.",

keywords = "Genetic risk, High-risk myeloma, Minimal residual disease, Newly diagnosed myeloma, Prognosis",

author = "Chutima Kunacheewa and Lee, \{Hans C.\} and Krina Patel and Sheeba Thomas and Behrang Amini and Samer Srour and Qaiser Bashir and Yago Nieto and Qazilbash, \{Muzzaffar H.\} and Weber, \{Donna M.\} and Lei Feng and Orlowski, \{Robert Z.\} and Pei Lin and Manasanch, \{Elisabet E.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = may,

doi = "10.1016/j.clml.2020.01.001",

language = "English",

volume = "20",

pages = "e221--e238",

journal = "Clinical Lymphoma, Myeloma and Leukemia",

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Kunacheewa, C, Lee, HC, Patel, K, Thomas, S, Amini, B, Srour, S, Bashir, Q, Nieto, Y, Qazilbash, MH, Weber, DM, Feng, L, Orlowski, RZ, Lin, P & Manasanch, EE 2020, 'Minimal Residual Disease Negativity Does Not Overcome Poor Prognosis in High-Risk Multiple Myeloma: A Single-Center Retrospective Study', Clinical Lymphoma, Myeloma and Leukemia, vol. 20, no. 5, pp. e221-e238. https://doi.org/10.1016/j.clml.2020.01.001

TY - JOUR

T1 - Minimal Residual Disease Negativity Does Not Overcome Poor Prognosis in High-Risk Multiple Myeloma

T2 - A Single-Center Retrospective Study

AU - Kunacheewa, Chutima

AU - Lee, Hans C.

AU - Patel, Krina

AU - Thomas, Sheeba

AU - Amini, Behrang

AU - Srour, Samer

AU - Bashir, Qaiser

AU - Nieto, Yago

AU - Qazilbash, Muzzaffar H.

AU - Weber, Donna M.

AU - Feng, Lei

AU - Orlowski, Robert Z.

AU - Lin, Pei

AU - Manasanch, Elisabet E.

PY - 2020/5

Y1 - 2020/5

N2 - Patients with multiple myeloma (MM) who experience deep remissions, including minimal residual disease (MRD) negativity, have better clinical outcomes compared to those do not. We aimed to describe the effect of testing for MRD negativity in a cohort of MM patients outside of a clinical trial. For most patients, MRD negativity supports improved clinical outcomes. However, in our cohort of patients with high-risk MM, MRD negativity does not seem to affect the overall poor prognosis.

AB - Patients with multiple myeloma (MM) who experience deep remissions, including minimal residual disease (MRD) negativity, have better clinical outcomes compared to those do not. We aimed to describe the effect of testing for MRD negativity in a cohort of MM patients outside of a clinical trial. For most patients, MRD negativity supports improved clinical outcomes. However, in our cohort of patients with high-risk MM, MRD negativity does not seem to affect the overall poor prognosis.

KW - Genetic risk

KW - High-risk myeloma

KW - Minimal residual disease

KW - Newly diagnosed myeloma

KW - Prognosis

UR - https://www.scopus.com/pages/publications/85078989364

U2 - 10.1016/j.clml.2020.01.001

DO - 10.1016/j.clml.2020.01.001

M3 - Article

C2 - 32037287

AN - SCOPUS:85078989364

SN - 2152-2650

VL - 20

SP - e221-e238

JO - Clinical Lymphoma, Myeloma and Leukemia

JF - Clinical Lymphoma, Myeloma and Leukemia

IS - 5

ER -

Minimal Residual Disease Negativity Does Not Overcome Poor Prognosis in High-Risk Multiple Myeloma: A Single-Center Retrospective Study

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Keywords

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