Metal-ion regulation of gene expression in yeast

Dennis R. Winge; Laran T. Jensen; Chandra Srinivasan

doi:10.1016/S1367-5931(98)80063-X

Metal-ion regulation of gene expression in yeast

Dennis R. Winge
, Laran T. Jensen
, Chandra Srinivasan

University of Utah Health

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Metal-responsive transcription factors exist in yeast to modulate expression of genes that encode proteins involved in cellular uptake of copper, iron and zinc ions. These signal transduction pathways function in the cellular regulation of the intracellular concentration of free metal ions. A second component of metal homeostasis is the regulation of metal-ion binding through protein-mediated metallation. Copper-specific chaperones exist in yeast that route copper ions to the site of biosynthesis of copper-metalloenzymes.

Original language	English
Pages (from-to)	216-221
Number of pages	6
Journal	Current Opinion in Chemical Biology
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/S1367-5931(98)80063-X
Publication status	Published - Apr 1998
Externally published	Yes

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10.1016/S1367-5931(98)80063-X

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title = "Metal-ion regulation of gene expression in yeast",

abstract = "Metal-responsive transcription factors exist in yeast to modulate expression of genes that encode proteins involved in cellular uptake of copper, iron and zinc ions. These signal transduction pathways function in the cellular regulation of the intracellular concentration of free metal ions. A second component of metal homeostasis is the regulation of metal-ion binding through protein-mediated metallation. Copper-specific chaperones exist in yeast that route copper ions to the site of biosynthesis of copper-metalloenzymes.",

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AU - Jensen, Laran T.

AU - Srinivasan, Chandra

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AB - Metal-responsive transcription factors exist in yeast to modulate expression of genes that encode proteins involved in cellular uptake of copper, iron and zinc ions. These signal transduction pathways function in the cellular regulation of the intracellular concentration of free metal ions. A second component of metal homeostasis is the regulation of metal-ion binding through protein-mediated metallation. Copper-specific chaperones exist in yeast that route copper ions to the site of biosynthesis of copper-metalloenzymes.

UR - https://www.scopus.com/pages/publications/0032039713

U2 - 10.1016/S1367-5931(98)80063-X

DO - 10.1016/S1367-5931(98)80063-X

M3 - Article

C2 - 9667925

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VL - 2

SP - 216

EP - 221

JO - Current Opinion in Chemical Biology

JF - Current Opinion in Chemical Biology

IS - 2

ER -

Metal-ion regulation of gene expression in yeast

Abstract

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