Membrane microparticles in VTE and cancer

Nigel S. Key; Pichika Chantrathammachart; Patrick W. Moody; Jen Yea Chang

doi:10.1016/S0049-3848(10)70020-7

Membrane microparticles in VTE and cancer

Nigel S. Key
, Pichika Chantrathammachart
, Patrick W. Moody
, Jen Yea Chang

University of North Carolina at Chapel Hill

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Microparticles (MPs) are cellular vesicles produced by all cells in response to apoptosis or cellular activation. In this brief review, the evidence that MPs mediate the thrombotic propensity that characterizes patients with cancer is evaluated. It is concluded that while considerable data exist to support a critical pathophysiologic role of host or tumor cell-derived MPs in cancer-associated thrombosis, causality is not yet firmly established. The results of prospective clinical studies that are currently underway should clarify any causative relationship.

Original language	English
Pages (from-to)	S80-S83
Journal	Thrombosis Research
Volume	125
DOIs	https://doi.org/10.1016/S0049-3848(10)70020-7
Publication status	Published - Apr 2010
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
Microparticle
Thrombosis
Tissue factor

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10.1016/S0049-3848(10)70020-7

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title = "Membrane microparticles in VTE and cancer",

abstract = "Microparticles (MPs) are cellular vesicles produced by all cells in response to apoptosis or cellular activation. In this brief review, the evidence that MPs mediate the thrombotic propensity that characterizes patients with cancer is evaluated. It is concluded that while considerable data exist to support a critical pathophysiologic role of host or tumor cell-derived MPs in cancer-associated thrombosis, causality is not yet firmly established. The results of prospective clinical studies that are currently underway should clarify any causative relationship.",

keywords = "Cancer, Microparticle, Thrombosis, Tissue factor",

author = "Key, \{Nigel S.\} and Pichika Chantrathammachart and Moody, \{Patrick W.\} and Chang, \{Jen Yea\}",

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language = "English",

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AU - Key, Nigel S.

AU - Chantrathammachart, Pichika

AU - Moody, Patrick W.

AU - Chang, Jen Yea

PY - 2010/4

Y1 - 2010/4

N2 - Microparticles (MPs) are cellular vesicles produced by all cells in response to apoptosis or cellular activation. In this brief review, the evidence that MPs mediate the thrombotic propensity that characterizes patients with cancer is evaluated. It is concluded that while considerable data exist to support a critical pathophysiologic role of host or tumor cell-derived MPs in cancer-associated thrombosis, causality is not yet firmly established. The results of prospective clinical studies that are currently underway should clarify any causative relationship.

AB - Microparticles (MPs) are cellular vesicles produced by all cells in response to apoptosis or cellular activation. In this brief review, the evidence that MPs mediate the thrombotic propensity that characterizes patients with cancer is evaluated. It is concluded that while considerable data exist to support a critical pathophysiologic role of host or tumor cell-derived MPs in cancer-associated thrombosis, causality is not yet firmly established. The results of prospective clinical studies that are currently underway should clarify any causative relationship.

KW - Cancer

KW - Microparticle

KW - Thrombosis

KW - Tissue factor

UR - https://www.scopus.com/pages/publications/77955508425

U2 - 10.1016/S0049-3848(10)70020-7

DO - 10.1016/S0049-3848(10)70020-7

M3 - Article

C2 - 20434013

AN - SCOPUS:77955508425

SN - 0049-3848

VL - 125

SP - S80-S83

JO - Thrombosis Research

JF - Thrombosis Research

ER -

Membrane microparticles in VTE and cancer

Abstract

UN SDGs

Keywords

Access to Document

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