Management Approach for Residual and Recurrent Mitral Regurgitation After Transcatheter Edge-to-Edge Repair

P.A.VillablancaPedro A.REMART Working Group

doi:10.1016/j.jcin.2026.02.045

Management Approach for Residual and Recurrent Mitral Regurgitation After Transcatheter Edge-to-Edge Repair

P.A.VillablancaPedro A.REMART Working Group

Department of Medicine

Henry Ford Health System
Atlantic Health
Chinese University of Hong Kong
Ludwig-Maximilians-University of Munich
Institute of Pharmacology
Leipzig Heart Center
Leeds Teaching Hospitals NHS Trust
Harvard Medical School
Roslyn
Chinese Academy of Medical Sciences and Peking Union Medical College
Hirslanden Clinic
The Christ Hospital - Cincinnati
San Raffaele Scientific Institute
University of Cambridge
St Antonius Hosp
Dept. of Med., Washington Hosp. Ctr.
University of California
University of Michigan Health System
Columbia University Medical Center
CardioVascular Center Frankfurt
Rigshospitalet
NCH Rooney Heart Institute
Mount Sinai Health System and Icahn School of Medicine at Mount Sinai
National Heart Center
Asan Medical Center
Clinique Pasteur
Minneapolis Heart Institute
Baylor College of Medicine
Vanderbilt University Medical Center
King Fahad Armed Forces Hospital
Ministry of Health Kuwait
MC 1035
West Virginia University
Tulane University School of Medicine
Queen Elizabeth Hospital Hong Kong
Zhejiang University School of Medicine
William Beaumont Hospital
Hôpital Bichat-Claude Bernard
Johannes Gutenberg University
International Heart Surgery Center Greece
Univ. of Nebraska Medical Center
Hong Kong Asia Heart Center
Aswan Heart Centre
Central Chest Institute of Thailand
Rajavithi Hospital
Hong Kong Sanatorium and Hospital
Mayo Clinic Rochester
Clemenceau Medical Center
Stanford University Medical Center
Prince Charles Hosp
Hirslanden Clinic Cecil
Universitair Ziekenhuis Brussel
University of Washington
Tokai University School of Medicine
Keio University School of Medicine
Nagoya Heart Center
Northwestern Memorial Hospital
National University Hospital
Asian Heart and Vascular Centre Singapore
Washington University in St. Louis
Fudan University
Sótero del Río Hospital
University of São Paulo
Oregon Health & Science University
University Medical Center Mainz
Inst Cardiol
University of Texas Health Science Center at Houston
University of Birmingham
University of California Irvine Medical Center
Yale School of Medicine
Los Robles Regional Medical Center

Research output: Contribution to journal › Review article › peer-review

Abstract

Mitral valve transcatheter edge-to-edge repair (M-TEER) is an established treatment option for patients with severe mitral regurgitation (MR) at high risk for surgery. However, the rate of recurrent MR ≥ 3+ after M-TEER may be up to 10% at 1 year. As the volume of M-TEER procedures increases, the number of patients experiencing recurrent MR post-TEER is also rising. M-TEER reshapes valve anatomy and complicates further treatment strategies for MR. In this review, the authors provide practical management considerations for patients with residual or recurrent MR after M-TEER.

Original language	English
Pages (from-to)	1071-1086
Number of pages	16
Journal	JACC: Cardiovascular Interventions
Volume	19
Issue number	9
DOIs	https://doi.org/10.1016/j.jcin.2026.02.045
Publication status	Published - 11 May 2026

Keywords

M-TEER
edge-to-edge repair
mitral regurgitation
recurrent MR
residual MR

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10.1016/j.jcin.2026.02.045

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@article{cd7ed9b8449a489d8f4c4ca5f21d5260,

title = "Management Approach for Residual and Recurrent Mitral Regurgitation After Transcatheter Edge-to-Edge Repair",

abstract = "Mitral valve transcatheter edge-to-edge repair (M-TEER) is an established treatment option for patients with severe mitral regurgitation (MR) at high risk for surgery. However, the rate of recurrent MR ≥ 3+ after M-TEER may be up to 10\% at 1 year. As the volume of M-TEER procedures increases, the number of patients experiencing recurrent MR post-TEER is also rising. M-TEER reshapes valve anatomy and complicates further treatment strategies for MR. In this review, the authors provide practical management considerations for patients with residual or recurrent MR after M-TEER.",

keywords = "M-TEER, edge-to-edge repair, mitral regurgitation, recurrent MR, residual MR",

author = "\{P.A.VillablancaPedro A.REMART Working Group\} and Fang, \{Jonathan X.\} and Gennaro Giustino and So, \{Kent Chak Yu\} and Lukas Stolz and Mateo Marin-Cuartas and Annette Maznyczka and Baron, \{Suzanne J.\} and Khan, \{Jaffar M.\} and Mi Chen and Maurizio Taramasso and Puvi Seshiah and Paolo Denti and Lee, \{Alex P.W.\} and Calvert, \{Patrick A.\} and Swanns, \{Martin J.\} and Toby Rogers and Singh, \{Gagan D.\} and Gorav Ailawadi and J{\"o}rg Hausleiter and Isaac George and Borger, \{Michael A.\} and Horst Sievert and Francesco Maisano and Ottavio Alfieri and \{de Backer\}, Ole and Wang, \{Dee Dee\} and McCabe, \{James M.\} and Hahn, \{Rebecca T.\} and Tang, \{Gilbert H.L.\} and Villablanca, \{Pedro A.\} and Fang, \{Jonathan X.\} and Gennaro Giustino and \{Chak-Yu So\}, Kent and Lukas Stolz and Mateo Marin-Cuartas and Kang, \{Do Yoon\} and Annette Maznyczka and Juri Iwata and Nadira Hamid and Ningyan Wong and Baron, \{Suzanne J.\} and Khan, \{Jaffar M.\} and Mi Chen and Maurizio Taramasso and Syed Zaid and Kashish Goel and Alessandro Beneduce and Mirvat Alasnag and Faisal Almajid and Krissada Meemook",

note = "Publisher Copyright: {\textcopyright} 2026 American College of Cardiology Foundation.",

year = "2026",

month = may,

day = "11",

doi = "10.1016/j.jcin.2026.02.045",

language = "English",

volume = "19",

pages = "1071--1086",

journal = "JACC: Cardiovascular Interventions",

issn = "1936-8798",

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T1 - Management Approach for Residual and Recurrent Mitral Regurgitation After Transcatheter Edge-to-Edge Repair

AU - P.A.VillablancaPedro A.REMART Working Group

AU - Fang, Jonathan X.

AU - Giustino, Gennaro

AU - So, Kent Chak Yu

AU - Stolz, Lukas

AU - Marin-Cuartas, Mateo

AU - Maznyczka, Annette

AU - Baron, Suzanne J.

AU - Khan, Jaffar M.

AU - Chen, Mi

AU - Taramasso, Maurizio

AU - Seshiah, Puvi

AU - Denti, Paolo

AU - Lee, Alex P.W.

AU - Calvert, Patrick A.

AU - Swanns, Martin J.

AU - Rogers, Toby

AU - Singh, Gagan D.

AU - Ailawadi, Gorav

AU - Hausleiter, Jörg

AU - George, Isaac

AU - Borger, Michael A.

AU - Sievert, Horst

AU - Maisano, Francesco

AU - Alfieri, Ottavio

AU - de Backer, Ole

AU - Wang, Dee Dee

AU - McCabe, James M.

AU - Hahn, Rebecca T.

AU - Tang, Gilbert H.L.

AU - Villablanca, Pedro A.

AU - Fang, Jonathan X.

AU - Giustino, Gennaro

AU - Chak-Yu So, Kent

AU - Stolz, Lukas

AU - Marin-Cuartas, Mateo

AU - Kang, Do Yoon

AU - Maznyczka, Annette

AU - Iwata, Juri

AU - Hamid, Nadira

AU - Wong, Ningyan

AU - Baron, Suzanne J.

AU - Khan, Jaffar M.

AU - Chen, Mi

AU - Taramasso, Maurizio

AU - Zaid, Syed

AU - Goel, Kashish

AU - Beneduce, Alessandro

AU - Alasnag, Mirvat

AU - Almajid, Faisal

AU - Meemook, Krissada

PY - 2026/5/11

Y1 - 2026/5/11

N2 - Mitral valve transcatheter edge-to-edge repair (M-TEER) is an established treatment option for patients with severe mitral regurgitation (MR) at high risk for surgery. However, the rate of recurrent MR ≥ 3+ after M-TEER may be up to 10% at 1 year. As the volume of M-TEER procedures increases, the number of patients experiencing recurrent MR post-TEER is also rising. M-TEER reshapes valve anatomy and complicates further treatment strategies for MR. In this review, the authors provide practical management considerations for patients with residual or recurrent MR after M-TEER.

AB - Mitral valve transcatheter edge-to-edge repair (M-TEER) is an established treatment option for patients with severe mitral regurgitation (MR) at high risk for surgery. However, the rate of recurrent MR ≥ 3+ after M-TEER may be up to 10% at 1 year. As the volume of M-TEER procedures increases, the number of patients experiencing recurrent MR post-TEER is also rising. M-TEER reshapes valve anatomy and complicates further treatment strategies for MR. In this review, the authors provide practical management considerations for patients with residual or recurrent MR after M-TEER.

KW - M-TEER

KW - edge-to-edge repair

KW - mitral regurgitation

KW - recurrent MR

KW - residual MR

UR - https://www.scopus.com/pages/publications/105038810176

U2 - 10.1016/j.jcin.2026.02.045

DO - 10.1016/j.jcin.2026.02.045

M3 - Review article

C2 - 42120115

AN - SCOPUS:105038810176

SN - 1936-8798

VL - 19

SP - 1071

EP - 1086

JO - JACC: Cardiovascular Interventions

JF - JACC: Cardiovascular Interventions

IS - 9

ER -

Management Approach for Residual and Recurrent Mitral Regurgitation After Transcatheter Edge-to-Edge Repair

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Keywords

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