Malnutrition and risks of atrial fibrillation recurrence after catheter ablation

Phuuwadith Wattanachayakul; Thitiphan Srikulmontri; Vitchapong Prasitsumrit; Thanathip Suenghataiphorn; Pojsakorn Danpanichkul; Jakrin Kewcharoen; Nipith Charoenngam; Sumeet Mainigi

doi:10.1002/joa3.13196

Malnutrition and risks of atrial fibrillation recurrence after catheter ablation

Phuuwadith Wattanachayakul
, Thitiphan Srikulmontri
, Vitchapong Prasitsumrit
, Thanathip Suenghataiphorn
, Pojsakorn Danpanichkul
, Jakrin Kewcharoen
, Nipith Charoenngam
, Sumeet Mainigi

Department of Medicine Jefferson Einstein Hospital Philadelphia Pennsylvania USA.
Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand
Department of Medicine Griffin Hospital Derby Connecticut USA.
Department of Medicine Texas Tech University Lubbock Texas USA.
Division of Cardiology University of California san Francisco San Francisco California USA.
Endocrine Unit Massachusetts General Hospital
Harvard Medical School Boston Massachusetts USA.
Sidney Kimmel Medical College Thomas Jefferson University Philadelphia Pennsylvania USA.

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Recent data showed an association between malnutrition and increased all-cause mortality and thromboembolic risk in patients with atrial fibrillation (AF). However, the impact of malnutrition on the clinical outcomes for patients undergoing catheter ablation for AF is still debated. Our study aimed to examine this relationship using all existing available data.

METHODS: We conducted a systematic review of MEDLINE and EMBASE databases from inception to April 2024, analyzing the association between malnutrition, assessed by the Geriatric Nutritional Risk Index (GNRI), and the risk of AF recurrence in patients who underwent catheter ablation for AF, compared to those without malnutrition. Relative Risk (RR) or hazard ratio (HR) and 95% CIs were retrieved from each study and combined using the generic inverse variance method.

RESULTS: We included 3 cohort studies with 1697 participants undergoing AF ablation (10.9%) who had malnutrition indicated by GNRI score below 98. Patients with malnutrition had a higher risk of AF recurrence following catheter ablation for AF compared to those without malnutrition (Pooled RR = 2.74, 95% CI 1.36-5.51, I 2 = 67%, p = .005).

CONCLUSIONS: Our pooled analysis indicates that malnourished patients undergoing catheter ablation for AF have an increased risk of AF recurrence compared to non-malnourished patients.

Original language	English
Pages (from-to)	e13196
Journal	Journal of Arrhythmia
Volume	41
Issue number	1
DOIs	https://doi.org/10.1002/joa3.13196
Publication status	Published - Feb 2025
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 2 Zero Hunger

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10.1002/joa3.13196

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@article{2986467211ac4cf0b188225061ac3198,

title = "Malnutrition and risks of atrial fibrillation recurrence after catheter ablation",

abstract = "BACKGROUND: Recent data showed an association between malnutrition and increased all-cause mortality and thromboembolic risk in patients with atrial fibrillation (AF). However, the impact of malnutrition on the clinical outcomes for patients undergoing catheter ablation for AF is still debated. Our study aimed to examine this relationship using all existing available data.METHODS: We conducted a systematic review of MEDLINE and EMBASE databases from inception to April 2024, analyzing the association between malnutrition, assessed by the Geriatric Nutritional Risk Index (GNRI), and the risk of AF recurrence in patients who underwent catheter ablation for AF, compared to those without malnutrition. Relative Risk (RR) or hazard ratio (HR) and 95\% CIs were retrieved from each study and combined using the generic inverse variance method.RESULTS: We included 3 cohort studies with 1697 participants undergoing AF ablation (10.9\%) who had malnutrition indicated by GNRI score below 98. Patients with malnutrition had a higher risk of AF recurrence following catheter ablation for AF compared to those without malnutrition (Pooled RR = 2.74, 95\% CI 1.36-5.51, I 2 = 67\%, p = .005). CONCLUSIONS: Our pooled analysis indicates that malnourished patients undergoing catheter ablation for AF have an increased risk of AF recurrence compared to non-malnourished patients.",

author = "Phuuwadith Wattanachayakul and Thitiphan Srikulmontri and Vitchapong Prasitsumrit and Thanathip Suenghataiphorn and Pojsakorn Danpanichkul and Jakrin Kewcharoen and Nipith Charoenngam and Sumeet Mainigi",

note = "{\textcopyright} 2024 The Author(s). Journal of Arrhythmia published by John Wiley \& Sons Australia, Ltd on behalf of Japanese Heart Rhythm Society.",

year = "2025",

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doi = "10.1002/joa3.13196",

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journal = "Journal of Arrhythmia",

issn = "1880-4276",

publisher = "John Wiley \& Sons Inc.",

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T1 - Malnutrition and risks of atrial fibrillation recurrence after catheter ablation

AU - Wattanachayakul, Phuuwadith

AU - Srikulmontri, Thitiphan

AU - Prasitsumrit, Vitchapong

AU - Suenghataiphorn, Thanathip

AU - Danpanichkul, Pojsakorn

AU - Kewcharoen, Jakrin

AU - Charoenngam, Nipith

AU - Mainigi, Sumeet

PY - 2025/2

Y1 - 2025/2

N2 - BACKGROUND: Recent data showed an association between malnutrition and increased all-cause mortality and thromboembolic risk in patients with atrial fibrillation (AF). However, the impact of malnutrition on the clinical outcomes for patients undergoing catheter ablation for AF is still debated. Our study aimed to examine this relationship using all existing available data.METHODS: We conducted a systematic review of MEDLINE and EMBASE databases from inception to April 2024, analyzing the association between malnutrition, assessed by the Geriatric Nutritional Risk Index (GNRI), and the risk of AF recurrence in patients who underwent catheter ablation for AF, compared to those without malnutrition. Relative Risk (RR) or hazard ratio (HR) and 95% CIs were retrieved from each study and combined using the generic inverse variance method.RESULTS: We included 3 cohort studies with 1697 participants undergoing AF ablation (10.9%) who had malnutrition indicated by GNRI score below 98. Patients with malnutrition had a higher risk of AF recurrence following catheter ablation for AF compared to those without malnutrition (Pooled RR = 2.74, 95% CI 1.36-5.51, I 2 = 67%, p = .005). CONCLUSIONS: Our pooled analysis indicates that malnourished patients undergoing catheter ablation for AF have an increased risk of AF recurrence compared to non-malnourished patients.

AB - BACKGROUND: Recent data showed an association between malnutrition and increased all-cause mortality and thromboembolic risk in patients with atrial fibrillation (AF). However, the impact of malnutrition on the clinical outcomes for patients undergoing catheter ablation for AF is still debated. Our study aimed to examine this relationship using all existing available data.METHODS: We conducted a systematic review of MEDLINE and EMBASE databases from inception to April 2024, analyzing the association between malnutrition, assessed by the Geriatric Nutritional Risk Index (GNRI), and the risk of AF recurrence in patients who underwent catheter ablation for AF, compared to those without malnutrition. Relative Risk (RR) or hazard ratio (HR) and 95% CIs were retrieved from each study and combined using the generic inverse variance method.RESULTS: We included 3 cohort studies with 1697 participants undergoing AF ablation (10.9%) who had malnutrition indicated by GNRI score below 98. Patients with malnutrition had a higher risk of AF recurrence following catheter ablation for AF compared to those without malnutrition (Pooled RR = 2.74, 95% CI 1.36-5.51, I 2 = 67%, p = .005). CONCLUSIONS: Our pooled analysis indicates that malnourished patients undergoing catheter ablation for AF have an increased risk of AF recurrence compared to non-malnourished patients.

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DO - 10.1002/joa3.13196

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SN - 1880-4276

VL - 41

SP - e13196

JO - Journal of Arrhythmia

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Malnutrition and risks of atrial fibrillation recurrence after catheter ablation

Abstract

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