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Label-free guided mode resonance sensor for detection of glycated hemoglobin

  • Boonrasri Seeleang
  • , Chamras Promptmas
  • , Sakoolkan Boonruang
  • , Waleed S. Mohammed
  • , Romuald Jolivot
  • Mahidol University
  • National Electronics and Computer Technology Center
  • Bangkok University

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Citations (Scopus)

Abstract

This paper demonstrates the use of Guided Mode Resonance (GMR) optical sensor platform for detection of Glycated Hemoglobin (HbA1c) in human blood. HbA1c is an importance biomarker for monitoring a long-Term glucose level in diabetes patients. Here, the sensing approach utilizes boronate affinity by modification of the GMR surface with 3- Aminophenylboronic acid (PBA). The sensing signal is then measured via a resonance shift in a reflection spectrum as the change of the refractive index on the sensor surface. In preliminary experiment, standard HbA1c samples with concentration covering the detection range (5% and 10 %) are used. The results show a good trend of resonance shift corresponding to amount of HbA1c.

Original languageEnglish
Title of host publication2017 Conference on Lasers and Electro-Optics Pacific Rim, CLEO-PR 2017
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1-2
Number of pages2
ISBN (Electronic)9781509062904
DOIs
Publication statusPublished - 22 Nov 2017
Event2017 Conference on Lasers and Electro-Optics Pacific Rim, CLEO-PR 2017 - Singapore, Singapore
Duration: 31 Jul 20174 Aug 2017

Publication series

Name2017 Conference on Lasers and Electro-Optics Pacific Rim, CLEO-PR 2017
Volume2017-January

Conference

Conference2017 Conference on Lasers and Electro-Optics Pacific Rim, CLEO-PR 2017
Country/TerritorySingapore
CitySingapore
Period31/07/174/08/17

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Boronate affinity
  • Glycated hemoglobin
  • Guided mode resonance
  • Optical sensor
  • Photonic crystals slab

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