Kinetics and Longevity of Antibody Response to Influenza a H5N1 Virus Infection in Humans

Rungrueng Kitphati; Phisanu Pooruk; Hatairat Lerdsamran; Siriwan Poosuwan; Suda Louisirirotchanakul; Prasert Auewarakul; Kulkanya Chokphaibulkit; Pirom Noisumdaeng; Pathom Sawanpanyalert; Pilaipan Puthavathana

doi:10.1128/CVI.00062-09

Kinetics and Longevity of Antibody Response to Influenza a H5N1 Virus Infection in Humans

Rungrueng Kitphati
, Phisanu Pooruk
, Hatairat Lerdsamran
, Siriwan Poosuwan
, Suda Louisirirotchanakul
, Prasert Auewarakul
, Kulkanya Chokphaibulkit
, Pirom Noisumdaeng
, Pathom Sawanpanyalert
, Pilaipan Puthavathana

Ministry of Public Health
Siriraj Hospital

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Anti-H5N1 antibody was determined by microneutralization, hemagglutination inhibition, and Western blotting assays in serial blood samples collected from eight Thai patients, including four fatal cases and four survivors. The antibody was detected as early as 5 days and, typically, with an increase in titer in paired blood at about 15 days after disease onset. The anti-H5 antibody response was long-lasting, for almost 5 years in cases which can be followed that far. In addition, cross-neutralizing activity to related clade 1 viruses was observed.

Original language	English
Pages (from-to)	978-981
Number of pages	4
Journal	Clinical and Vaccine Immunology
Volume	16
Issue number	7
DOIs	https://doi.org/10.1128/CVI.00062-09
Publication status	Published - Jul 2009

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10.1128/CVI.00062-09

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abstract = "Anti-H5N1 antibody was determined by microneutralization, hemagglutination inhibition, and Western blotting assays in serial blood samples collected from eight Thai patients, including four fatal cases and four survivors. The antibody was detected as early as 5 days and, typically, with an increase in titer in paired blood at about 15 days after disease onset. The anti-H5 antibody response was long-lasting, for almost 5 years in cases which can be followed that far. In addition, cross-neutralizing activity to related clade 1 viruses was observed.",

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AU - Kitphati, Rungrueng

AU - Pooruk, Phisanu

AU - Lerdsamran, Hatairat

AU - Poosuwan, Siriwan

AU - Louisirirotchanakul, Suda

AU - Auewarakul, Prasert

AU - Chokphaibulkit, Kulkanya

AU - Noisumdaeng, Pirom

AU - Sawanpanyalert, Pathom

AU - Puthavathana, Pilaipan

PY - 2009/7

Y1 - 2009/7

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AB - Anti-H5N1 antibody was determined by microneutralization, hemagglutination inhibition, and Western blotting assays in serial blood samples collected from eight Thai patients, including four fatal cases and four survivors. The antibody was detected as early as 5 days and, typically, with an increase in titer in paired blood at about 15 days after disease onset. The anti-H5 antibody response was long-lasting, for almost 5 years in cases which can be followed that far. In addition, cross-neutralizing activity to related clade 1 viruses was observed.

UR - https://www.scopus.com/pages/publications/67650355473

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AN - SCOPUS:67650355473

SN - 1556-6811

VL - 16

SP - 978

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JO - Clinical and Vaccine Immunology

JF - Clinical and Vaccine Immunology

IS - 7

ER -

Kinetics and Longevity of Antibody Response to Influenza a H5N1 Virus Infection in Humans

Abstract

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