In vitro efficacy of antimalarial drugs against Plasmodium vivax on the western border of Thailand

Kesinee Chotivanich; Rachanee Udomsangpetch; Wirongrong Chierakul; Paul N. Newton; Ronatrai Ruangveerayuth; Sasithon Pukrittayakamee; Sornchai Looareesuwan; Nicholas J. White

doi:10.4269/ajtmh.2004.70.395

In vitro efficacy of antimalarial drugs against Plasmodium vivax on the western border of Thailand

Kesinee Chotivanich
, Rachanee Udomsangpetch
, Wirongrong Chierakul
, Paul N. Newton
, Ronatrai Ruangveerayuth
, Sasithon Pukrittayakamee
, Sornchai Looareesuwan
, Nicholas J. White

Department of Clinical Tropical Medicine

Mahidol University
Faculty of Tropical Medicine, Mahidol University
Churchill Hospital
Mae Sot Hospital

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

The susceptibility of 20 isolates of Plasmodium vivax on the Thailand-Myanmar border to seven antimalarial drugs was evaluated using the schizont maturation inhibition technique. The geometric mean 50% inhibition concentration (IC₅₀) values were quinine = 308 ng/mL, amodiaquine = 14 ng/mL, chloroquine = 50 ng/mL, mefloquine = 127 ng/mL, sulfadoxine/pyrimethamine (80:1) = 800/10 ng/mL, pyrimethamine = 8 ng/mL, and artesunate = 0.5 ng/mL. Compared with P. falciparum in this area, P. vivax was more sensitive to chloroquine and artesunate, equally sensitive to quinine, and more resistant to mefloquine.

Original language	English
Pages (from-to)	395-397
Number of pages	3
Journal	American Journal of Tropical Medicine and Hygiene
Volume	70
Issue number	4
DOIs	https://doi.org/10.4269/ajtmh.2004.70.395
Publication status	Published - Apr 2004

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.4269/ajtmh.2004.70.395

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title = "In vitro efficacy of antimalarial drugs against Plasmodium vivax on the western border of Thailand",

abstract = "The susceptibility of 20 isolates of Plasmodium vivax on the Thailand-Myanmar border to seven antimalarial drugs was evaluated using the schizont maturation inhibition technique. The geometric mean 50\% inhibition concentration (IC50) values were quinine = 308 ng/mL, amodiaquine = 14 ng/mL, chloroquine = 50 ng/mL, mefloquine = 127 ng/mL, sulfadoxine/pyrimethamine (80:1) = 800/10 ng/mL, pyrimethamine = 8 ng/mL, and artesunate = 0.5 ng/mL. Compared with P. falciparum in this area, P. vivax was more sensitive to chloroquine and artesunate, equally sensitive to quinine, and more resistant to mefloquine.",

author = "Kesinee Chotivanich and Rachanee Udomsangpetch and Wirongrong Chierakul and Newton, \{Paul N.\} and Ronatrai Ruangveerayuth and Sasithon Pukrittayakamee and Sornchai Looareesuwan and White, \{Nicholas J.\}",

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doi = "10.4269/ajtmh.2004.70.395",

language = "English",

volume = "70",

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AU - Chotivanich, Kesinee

AU - Udomsangpetch, Rachanee

AU - Chierakul, Wirongrong

AU - Newton, Paul N.

AU - Ruangveerayuth, Ronatrai

AU - Pukrittayakamee, Sasithon

AU - Looareesuwan, Sornchai

AU - White, Nicholas J.

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N2 - The susceptibility of 20 isolates of Plasmodium vivax on the Thailand-Myanmar border to seven antimalarial drugs was evaluated using the schizont maturation inhibition technique. The geometric mean 50% inhibition concentration (IC50) values were quinine = 308 ng/mL, amodiaquine = 14 ng/mL, chloroquine = 50 ng/mL, mefloquine = 127 ng/mL, sulfadoxine/pyrimethamine (80:1) = 800/10 ng/mL, pyrimethamine = 8 ng/mL, and artesunate = 0.5 ng/mL. Compared with P. falciparum in this area, P. vivax was more sensitive to chloroquine and artesunate, equally sensitive to quinine, and more resistant to mefloquine.

AB - The susceptibility of 20 isolates of Plasmodium vivax on the Thailand-Myanmar border to seven antimalarial drugs was evaluated using the schizont maturation inhibition technique. The geometric mean 50% inhibition concentration (IC50) values were quinine = 308 ng/mL, amodiaquine = 14 ng/mL, chloroquine = 50 ng/mL, mefloquine = 127 ng/mL, sulfadoxine/pyrimethamine (80:1) = 800/10 ng/mL, pyrimethamine = 8 ng/mL, and artesunate = 0.5 ng/mL. Compared with P. falciparum in this area, P. vivax was more sensitive to chloroquine and artesunate, equally sensitive to quinine, and more resistant to mefloquine.

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EP - 397

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

IS - 4

ER -

In vitro efficacy of antimalarial drugs against Plasmodium vivax on the western border of Thailand

Abstract

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