IBX/n-Bu4NBr/CH2Cl2-H2O: A new mild system for selective oxidation of secondary alcohols

Chutima Kuhakarn; Krisada Kittigowittana; Manat Pohmakotr; Vichai Reutrakul

doi:10.1016/j.tet.2005.07.051

IBX/n-Bu₄NBr/CH₂Cl₂-H₂O: A new mild system for selective oxidation of secondary alcohols

Chutima Kuhakarn
, Krisada Kittigowittana
, Manat Pohmakotr
, Vichai Reutrakul

Mahidol University

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

A new alternative system for the chemoselective oxidation of secondary hydroxyl group to ketone with IBX/n-Bu₄NBr in CH₂Cl ₂-H₂O has been developed. Under the reaction conditions, the secondary hydroxyl group was highly chemoselectively oxidized to the corresponding ketone, in moderate to good yields at rt, in the presence of primary hydroxyl group within the same molecule.

Original language	English
Pages (from-to)	8995-9000
Number of pages	6
Journal	Tetrahedron
Volume	61
Issue number	38
DOIs	https://doi.org/10.1016/j.tet.2005.07.051
Publication status	Published - 19 Sept 2005
Externally published	Yes

Keywords

IBX oxidation
Selective oxidation

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10.1016/j.tet.2005.07.051

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title = "IBX/n-Bu4NBr/CH2Cl2-H2O: A new mild system for selective oxidation of secondary alcohols",

abstract = "A new alternative system for the chemoselective oxidation of secondary hydroxyl group to ketone with IBX/n-Bu4NBr in CH2Cl 2-H2O has been developed. Under the reaction conditions, the secondary hydroxyl group was highly chemoselectively oxidized to the corresponding ketone, in moderate to good yields at rt, in the presence of primary hydroxyl group within the same molecule.",

keywords = "IBX oxidation, Selective oxidation",

author = "Chutima Kuhakarn and Krisada Kittigowittana and Manat Pohmakotr and Vichai Reutrakul",

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TY - JOUR

T1 - IBX/n-Bu4NBr/CH2Cl2-H2O

T2 - A new mild system for selective oxidation of secondary alcohols

AU - Kuhakarn, Chutima

AU - Kittigowittana, Krisada

AU - Pohmakotr, Manat

AU - Reutrakul, Vichai

PY - 2005/9/19

Y1 - 2005/9/19

N2 - A new alternative system for the chemoselective oxidation of secondary hydroxyl group to ketone with IBX/n-Bu4NBr in CH2Cl 2-H2O has been developed. Under the reaction conditions, the secondary hydroxyl group was highly chemoselectively oxidized to the corresponding ketone, in moderate to good yields at rt, in the presence of primary hydroxyl group within the same molecule.

AB - A new alternative system for the chemoselective oxidation of secondary hydroxyl group to ketone with IBX/n-Bu4NBr in CH2Cl 2-H2O has been developed. Under the reaction conditions, the secondary hydroxyl group was highly chemoselectively oxidized to the corresponding ketone, in moderate to good yields at rt, in the presence of primary hydroxyl group within the same molecule.

KW - IBX oxidation

KW - Selective oxidation

UR - https://www.scopus.com/pages/publications/23944511343

U2 - 10.1016/j.tet.2005.07.051

DO - 10.1016/j.tet.2005.07.051

M3 - Article

AN - SCOPUS:23944511343

SN - 0040-4020

VL - 61

SP - 8995

EP - 9000

JO - Tetrahedron

JF - Tetrahedron

IS - 38

ER -

IBX/n-Bu₄NBr/CH₂Cl₂-H₂O: A new mild system for selective oxidation of secondary alcohols

Abstract

Keywords

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