Gamma Irradiation Synthesis of Sugar-Derived Carbon-Dot-Functionalized Glutathione for Hg2+ Detection and Antioxidant Activity

Kanokorn Wechakorn; Pacharaphon Khaopueak; Varistha Chobpattana; Natakorn Sapermsap; Sorawis Sangtawesin; Tanagorn Sangtawesin

doi:10.1021/acsomega.4c08009

Gamma Irradiation Synthesis of Sugar-Derived Carbon-Dot-Functionalized Glutathione for Hg²⁺ Detection and Antioxidant Activity

Kanokorn Wechakorn
, Pacharaphon Khaopueak
, Varistha Chobpattana
, Natakorn Sapermsap
, Sorawis Sangtawesin
, Tanagorn Sangtawesin

Rajamangala Institute of Technology
Suranaree University of Technology
Thailand Institute of Nuclear Technology (Public Organization)

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Mercury, a particularly toxic heavy metal from industrial processes, poses significant risks to both people and the environment when it accumulates to dangerous levels, damaging the liver, kidneys, and nervous system. Therefore, fluorescent organic carbon dots (CDs) were developed for detecting Hg²⁺ ions. These CDs were easily synthesized, chemically stable, biocompatible, low in toxicity, and environmentally friendly. In this work, glutathione-functionalized CDs (CDs-GSH) were produced from sugar using the EDC/NHS coupling method. Gamma irradiation induced the chemical reactions necessary to produce fluorescent CDs. CDs-GSH demonstrated significant selectivity for Hg²⁺ with an 83% reduction in fluorescence intensity. Additionally, they exhibited a phenolic content of 19.1 μg/mg GAE and strong antioxidant characteristics, with DPPH radical scavenging activity of 63% at 1.0 mg/mL. Due to their stability, selectivity, and antioxidant qualities, high-value CDs can be produced from table sugar using an environmentally friendly synthesis process, offering potential applications in sensing and antioxidant activity.

Original language	English
Pages (from-to)	4496-4504
Number of pages	9
Journal	ACS Omega
Volume	10
Issue number	5
DOIs	https://doi.org/10.1021/acsomega.4c08009
Publication status	Published - 11 Feb 2025
Externally published	Yes

Access to Document

10.1021/acsomega.4c08009

Cite this

@article{cf1e8c2a3568432db8380a490d2835aa,

title = "Gamma Irradiation Synthesis of Sugar-Derived Carbon-Dot-Functionalized Glutathione for Hg2+ Detection and Antioxidant Activity",

abstract = "Mercury, a particularly toxic heavy metal from industrial processes, poses significant risks to both people and the environment when it accumulates to dangerous levels, damaging the liver, kidneys, and nervous system. Therefore, fluorescent organic carbon dots (CDs) were developed for detecting Hg2+ ions. These CDs were easily synthesized, chemically stable, biocompatible, low in toxicity, and environmentally friendly. In this work, glutathione-functionalized CDs (CDs-GSH) were produced from sugar using the EDC/NHS coupling method. Gamma irradiation induced the chemical reactions necessary to produce fluorescent CDs. CDs-GSH demonstrated significant selectivity for Hg2+ with an 83\% reduction in fluorescence intensity. Additionally, they exhibited a phenolic content of 19.1 μg/mg GAE and strong antioxidant characteristics, with DPPH radical scavenging activity of 63\% at 1.0 mg/mL. Due to their stability, selectivity, and antioxidant qualities, high-value CDs can be produced from table sugar using an environmentally friendly synthesis process, offering potential applications in sensing and antioxidant activity.",

author = "Kanokorn Wechakorn and Pacharaphon Khaopueak and Varistha Chobpattana and Natakorn Sapermsap and Sorawis Sangtawesin and Tanagorn Sangtawesin",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors. Published by American Chemical Society.",

year = "2025",

month = feb,

day = "11",

doi = "10.1021/acsomega.4c08009",

language = "English",

volume = "10",

pages = "4496--4504",

journal = "ACS Omega",

issn = "2470-1343",

publisher = "American Chemical Society",

number = "5",

}

TY - JOUR

T1 - Gamma Irradiation Synthesis of Sugar-Derived Carbon-Dot-Functionalized Glutathione for Hg2+ Detection and Antioxidant Activity

AU - Wechakorn, Kanokorn

AU - Khaopueak, Pacharaphon

AU - Chobpattana, Varistha

AU - Sapermsap, Natakorn

AU - Sangtawesin, Sorawis

AU - Sangtawesin, Tanagorn

PY - 2025/2/11

Y1 - 2025/2/11

N2 - Mercury, a particularly toxic heavy metal from industrial processes, poses significant risks to both people and the environment when it accumulates to dangerous levels, damaging the liver, kidneys, and nervous system. Therefore, fluorescent organic carbon dots (CDs) were developed for detecting Hg2+ ions. These CDs were easily synthesized, chemically stable, biocompatible, low in toxicity, and environmentally friendly. In this work, glutathione-functionalized CDs (CDs-GSH) were produced from sugar using the EDC/NHS coupling method. Gamma irradiation induced the chemical reactions necessary to produce fluorescent CDs. CDs-GSH demonstrated significant selectivity for Hg2+ with an 83% reduction in fluorescence intensity. Additionally, they exhibited a phenolic content of 19.1 μg/mg GAE and strong antioxidant characteristics, with DPPH radical scavenging activity of 63% at 1.0 mg/mL. Due to their stability, selectivity, and antioxidant qualities, high-value CDs can be produced from table sugar using an environmentally friendly synthesis process, offering potential applications in sensing and antioxidant activity.

AB - Mercury, a particularly toxic heavy metal from industrial processes, poses significant risks to both people and the environment when it accumulates to dangerous levels, damaging the liver, kidneys, and nervous system. Therefore, fluorescent organic carbon dots (CDs) were developed for detecting Hg2+ ions. These CDs were easily synthesized, chemically stable, biocompatible, low in toxicity, and environmentally friendly. In this work, glutathione-functionalized CDs (CDs-GSH) were produced from sugar using the EDC/NHS coupling method. Gamma irradiation induced the chemical reactions necessary to produce fluorescent CDs. CDs-GSH demonstrated significant selectivity for Hg2+ with an 83% reduction in fluorescence intensity. Additionally, they exhibited a phenolic content of 19.1 μg/mg GAE and strong antioxidant characteristics, with DPPH radical scavenging activity of 63% at 1.0 mg/mL. Due to their stability, selectivity, and antioxidant qualities, high-value CDs can be produced from table sugar using an environmentally friendly synthesis process, offering potential applications in sensing and antioxidant activity.

UR - https://www.scopus.com/pages/publications/85216960328

U2 - 10.1021/acsomega.4c08009

DO - 10.1021/acsomega.4c08009

M3 - Article

AN - SCOPUS:85216960328

SN - 2470-1343

VL - 10

SP - 4496

EP - 4504

JO - ACS Omega

JF - ACS Omega

IS - 5

ER -

Gamma Irradiation Synthesis of Sugar-Derived Carbon-Dot-Functionalized Glutathione for Hg²⁺ Detection and Antioxidant Activity

Abstract

Access to Document

Other files and links

Fingerprint

Cite this