Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses

Canan G. Nebigil; Christiane Moog; Stéphan Vagner; Nadia Benkirane-Jessel; Duncan R. Smith; Laurent Désaubry

doi:10.1016/j.ejmech.2020.112653

Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses

Canan G. Nebigil
, Christiane Moog
, Stéphan Vagner
, Nadia Benkirane-Jessel
, Duncan R. Smith
, Laurent Désaubry

Medical Biotechnology Sciences Academic Group

FMTS
Hopitaux Universitaires Strasbourg
Institut Curie
Université Paris-Sud
University of Strasbourg

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Original language	English
Article number	112653
Journal	European Journal of Medicinal Chemistry
Volume	203
DOIs	https://doi.org/10.1016/j.ejmech.2020.112653
Publication status	Published - 1 Oct 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COVID-19
Chikungunya virus
Coronavirus
Ebola virus
Natural products
Picornaviruses
Prohibitin
SARS-CoV-2
Zika virus
eIF4A

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10.1016/j.ejmech.2020.112653

Cite this

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title = "Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses",

abstract = "Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).",

keywords = "COVID-19, Chikungunya virus, Coronavirus, Ebola virus, Natural products, Picornaviruses, Prohibitin, SARS-CoV-2, Zika virus, eIF4A",

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doi = "10.1016/j.ejmech.2020.112653",

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T2 - From traditional Chinese medicine to antiviral activity against coronaviruses

AU - Nebigil, Canan G.

AU - Moog, Christiane

AU - Vagner, Stéphan

AU - Benkirane-Jessel, Nadia

AU - Smith, Duncan R.

AU - Désaubry, Laurent

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AB - Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

KW - COVID-19

KW - Chikungunya virus

KW - Coronavirus

KW - Ebola virus

KW - Natural products

KW - Picornaviruses

KW - Prohibitin

KW - SARS-CoV-2

KW - Zika virus

KW - eIF4A

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DO - 10.1016/j.ejmech.2020.112653

M3 - Article

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JF - European Journal of Medicinal Chemistry

M1 - 112653

ER -

Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses

Abstract

UN SDGs

Keywords

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