Expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS) induced in Burkholderia pseudomallei-infected mouse macrophages requires bacterial internalization

P. Ekchariyawat; S. Pudla; K. Limposuwan; S. Arjcharoen; S. Sirisinha; P. Utaisincharoen

doi:10.1016/j.micpath.2006.11.004

Expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS) induced in Burkholderia pseudomallei-infected mouse macrophages requires bacterial internalization

P. Ekchariyawat
, S. Pudla
, K. Limposuwan
, S. Arjcharoen
, S. Sirisinha
, P. Utaisincharoen

Mahidol University

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We recently reported that Burkholderia pseudomallei was able to activate the expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS). In the present study, we presented evidence showing that the induction of these negative regulators was most probably triggered from within rather than at the cell surface of mouse macrophage cell line (RAW264.7) suggesting that macrophage activation most likely requires the interaction of bacteria with a putative host cell cytoplasmic component(s).

Original language	English
Pages (from-to)	104-110
Number of pages	7
Journal	Microbial Pathogenesis
Volume	42
Issue number	2-3
DOIs	https://doi.org/10.1016/j.micpath.2006.11.004
Publication status	Published - Feb 2007
Externally published	Yes

Keywords

B. pseudomallei
CIS
Melioidosis
SOCS
SOCS3

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10.1016/j.micpath.2006.11.004

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Ekchariyawat, P., Pudla, S., Limposuwan, K., Arjcharoen, S., Sirisinha, S., & Utaisincharoen, P. (2007). Expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS) induced in Burkholderia pseudomallei-infected mouse macrophages requires bacterial internalization. Microbial Pathogenesis, 42(2-3), 104-110. https://doi.org/10.1016/j.micpath.2006.11.004

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title = "Expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS) induced in Burkholderia pseudomallei-infected mouse macrophages requires bacterial internalization",

abstract = "We recently reported that Burkholderia pseudomallei was able to activate the expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS). In the present study, we presented evidence showing that the induction of these negative regulators was most probably triggered from within rather than at the cell surface of mouse macrophage cell line (RAW264.7) suggesting that macrophage activation most likely requires the interaction of bacteria with a putative host cell cytoplasmic component(s).",

keywords = "B. pseudomallei, CIS, Melioidosis, SOCS, SOCS3",

author = "P. Ekchariyawat and S. Pudla and K. Limposuwan and S. Arjcharoen and S. Sirisinha and P. Utaisincharoen",

year = "2007",

month = feb,

doi = "10.1016/j.micpath.2006.11.004",

language = "English",

volume = "42",

pages = "104--110",

journal = "Microbial Pathogenesis",

issn = "0882-4010",

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number = "2-3",

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Ekchariyawat, P, Pudla, S, Limposuwan, K, Arjcharoen, S, Sirisinha, S & Utaisincharoen, P 2007, 'Expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS) induced in Burkholderia pseudomallei-infected mouse macrophages requires bacterial internalization', Microbial Pathogenesis, vol. 42, no. 2-3, pp. 104-110. https://doi.org/10.1016/j.micpath.2006.11.004

Expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS) induced in Burkholderia pseudomallei-infected mouse macrophages requires bacterial internalization. / Ekchariyawat, P.; Pudla, S.; Limposuwan, K. et al.
In: Microbial Pathogenesis, Vol. 42, No. 2-3, 02.2007, p. 104-110.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS) induced in Burkholderia pseudomallei-infected mouse macrophages requires bacterial internalization

AU - Ekchariyawat, P.

AU - Pudla, S.

AU - Limposuwan, K.

AU - Arjcharoen, S.

AU - Sirisinha, S.

AU - Utaisincharoen, P.

PY - 2007/2

Y1 - 2007/2

N2 - We recently reported that Burkholderia pseudomallei was able to activate the expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS). In the present study, we presented evidence showing that the induction of these negative regulators was most probably triggered from within rather than at the cell surface of mouse macrophage cell line (RAW264.7) suggesting that macrophage activation most likely requires the interaction of bacteria with a putative host cell cytoplasmic component(s).

AB - We recently reported that Burkholderia pseudomallei was able to activate the expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS). In the present study, we presented evidence showing that the induction of these negative regulators was most probably triggered from within rather than at the cell surface of mouse macrophage cell line (RAW264.7) suggesting that macrophage activation most likely requires the interaction of bacteria with a putative host cell cytoplasmic component(s).

KW - B. pseudomallei

KW - CIS

KW - Melioidosis

KW - SOCS

KW - SOCS3

UR - https://www.scopus.com/pages/publications/33847143167

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DO - 10.1016/j.micpath.2006.11.004

M3 - Article

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AN - SCOPUS:33847143167

SN - 0882-4010

VL - 42

SP - 104

EP - 110

JO - Microbial Pathogenesis

JF - Microbial Pathogenesis

IS - 2-3

ER -

Ekchariyawat P, Pudla S, Limposuwan K, Arjcharoen S, Sirisinha S, Utaisincharoen P. Expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS) induced in Burkholderia pseudomallei-infected mouse macrophages requires bacterial internalization. Microbial Pathogenesis. 2007 Feb;42(2-3):104-110. doi: 10.1016/j.micpath.2006.11.004

Expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS) induced in Burkholderia pseudomallei-infected mouse macrophages requires bacterial internalization

Abstract

Keywords

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