Eremophilane sesquiterpenes and diphenyl thioethers from the soil fungus Penicillium copticola PSU-RSPG138

Charuwan Daengrot; Vatcharin Rukachaisirikul; Chittreeya Tansakul; Tienthong Thongpanchang; Souwalak Phongpaichit; Kawitsara Bowornwiriyapan; Jariya Sakayaroj

doi:10.1021/np5005328

Eremophilane sesquiterpenes and diphenyl thioethers from the soil fungus Penicillium copticola PSU-RSPG138

Charuwan Daengrot
, Vatcharin Rukachaisirikul
, Chittreeya Tansakul
, Tienthong Thongpanchang
, Souwalak Phongpaichit
, Kawitsara Bowornwiriyapan
, Jariya Sakayaroj

Prince of Songkla University
Mahidol University
National Science and Technology Development Agency (NSTDA)

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Four new compounds including two eremophilane sesquiterpenes, penicilleremophilanes A (1) and B (2), as well as two sulfur-containing biphenols, penicillithiophenols A (3) and B (4), were isolated from the soil fungus Penicillium copticola PSU-RSPG138 together with 16 known compounds. Their structures were elucidated by spectroscopic methods. Known sporogen AO-1 exhibited significant antimalarial activity against Plasmodium falciparum with an IC₅₀ value of 1.53 μM and cytotoxic activity to noncancerous (Vero) cell lines with an IC₅₀ value of 4.23 μM. Although compound 1 was approximately half as active against P. falciparum with the IC₅₀ value of 3.45 μM, it showed much weaker cytotoxic activity.

Original language	English
Pages (from-to)	615-622
Number of pages	8
Journal	Journal of Natural Products
Volume	78
Issue number	4
DOIs	https://doi.org/10.1021/np5005328
Publication status	Published - 24 Apr 2015
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1021/np5005328

Cite this

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title = "Eremophilane sesquiterpenes and diphenyl thioethers from the soil fungus Penicillium copticola PSU-RSPG138",

abstract = "Four new compounds including two eremophilane sesquiterpenes, penicilleremophilanes A (1) and B (2), as well as two sulfur-containing biphenols, penicillithiophenols A (3) and B (4), were isolated from the soil fungus Penicillium copticola PSU-RSPG138 together with 16 known compounds. Their structures were elucidated by spectroscopic methods. Known sporogen AO-1 exhibited significant antimalarial activity against Plasmodium falciparum with an IC50 value of 1.53 μM and cytotoxic activity to noncancerous (Vero) cell lines with an IC50 value of 4.23 μM. Although compound 1 was approximately half as active against P. falciparum with the IC50 value of 3.45 μM, it showed much weaker cytotoxic activity.",

author = "Charuwan Daengrot and Vatcharin Rukachaisirikul and Chittreeya Tansakul and Tienthong Thongpanchang and Souwalak Phongpaichit and Kawitsara Bowornwiriyapan and Jariya Sakayaroj",

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doi = "10.1021/np5005328",

language = "English",

volume = "78",

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T1 - Eremophilane sesquiterpenes and diphenyl thioethers from the soil fungus Penicillium copticola PSU-RSPG138

AU - Daengrot, Charuwan

AU - Rukachaisirikul, Vatcharin

AU - Tansakul, Chittreeya

AU - Thongpanchang, Tienthong

AU - Phongpaichit, Souwalak

AU - Bowornwiriyapan, Kawitsara

AU - Sakayaroj, Jariya

PY - 2015/4/24

Y1 - 2015/4/24

N2 - Four new compounds including two eremophilane sesquiterpenes, penicilleremophilanes A (1) and B (2), as well as two sulfur-containing biphenols, penicillithiophenols A (3) and B (4), were isolated from the soil fungus Penicillium copticola PSU-RSPG138 together with 16 known compounds. Their structures were elucidated by spectroscopic methods. Known sporogen AO-1 exhibited significant antimalarial activity against Plasmodium falciparum with an IC50 value of 1.53 μM and cytotoxic activity to noncancerous (Vero) cell lines with an IC50 value of 4.23 μM. Although compound 1 was approximately half as active against P. falciparum with the IC50 value of 3.45 μM, it showed much weaker cytotoxic activity.

AB - Four new compounds including two eremophilane sesquiterpenes, penicilleremophilanes A (1) and B (2), as well as two sulfur-containing biphenols, penicillithiophenols A (3) and B (4), were isolated from the soil fungus Penicillium copticola PSU-RSPG138 together with 16 known compounds. Their structures were elucidated by spectroscopic methods. Known sporogen AO-1 exhibited significant antimalarial activity against Plasmodium falciparum with an IC50 value of 1.53 μM and cytotoxic activity to noncancerous (Vero) cell lines with an IC50 value of 4.23 μM. Although compound 1 was approximately half as active against P. falciparum with the IC50 value of 3.45 μM, it showed much weaker cytotoxic activity.

UR - https://www.scopus.com/pages/publications/84928819084

U2 - 10.1021/np5005328

DO - 10.1021/np5005328

M3 - Article

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SN - 0163-3864

VL - 78

SP - 615

EP - 622

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 4

ER -

Eremophilane sesquiterpenes and diphenyl thioethers from the soil fungus Penicillium copticola PSU-RSPG138

Abstract

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