TY - GEN
T1 - Effect of surfactant on characteristics of solid lipid nanoparticles (SLN)
AU - Kullavadee, Karn Orachai
AU - Uracha, Ruktanonchai
AU - Smith, Siwaporn Meejoo
PY - 2012
Y1 - 2012
N2 - SLN have shown a great promise as an alternative drug carrier for intravenous and dermal applications. This work focuses on the basic properties of drug-free Compritol® ATO 888 based SLN systems by using cationic surfactant (CPC) and nonionic surfactant (Tween 80). Effects of surfactant on the physical properties of SLNs were investigated in the absence of model drug to avoid the interaction between drug and surfactant. These SLN samples have different particle size, zeta potential and morphology. DSC was used to quantify the crystallinity of SLN systems. It was found that %RI of both SLNs was similar, indicating that types of surfactant did not affect on crystallization of solid lipid. Spherical-like particle was observed with SLN-C, while rod-like particle was found with SLN-T. The results demonstrated that surfactant plays an important role on SLN physical characteristics.
AB - SLN have shown a great promise as an alternative drug carrier for intravenous and dermal applications. This work focuses on the basic properties of drug-free Compritol® ATO 888 based SLN systems by using cationic surfactant (CPC) and nonionic surfactant (Tween 80). Effects of surfactant on the physical properties of SLNs were investigated in the absence of model drug to avoid the interaction between drug and surfactant. These SLN samples have different particle size, zeta potential and morphology. DSC was used to quantify the crystallinity of SLN systems. It was found that %RI of both SLNs was similar, indicating that types of surfactant did not affect on crystallization of solid lipid. Spherical-like particle was observed with SLN-C, while rod-like particle was found with SLN-T. The results demonstrated that surfactant plays an important role on SLN physical characteristics.
KW - Raman mapping and drug distribution
KW - Raman spectroscopy
KW - Solid lipid nanoparticles
KW - Surfactant
UR - https://www.scopus.com/pages/publications/81855187238
U2 - 10.4028/www.scientific.net/AMR.364.313
DO - 10.4028/www.scientific.net/AMR.364.313
M3 - Conference contribution
AN - SCOPUS:81855187238
SN - 9783037853016
T3 - Advanced Materials Research
SP - 313
EP - 316
BT - Nanomaterials
T2 - 2011 International Conference on Nanomaterials, Synthesis and Characterization, ICNSC2011
Y2 - 4 July 2011 through 5 July 2011
ER -