Abstract
An efficient synthetic method for coumarin derivatives was developed using a dual organocatalytic reaction. A combination of ptoluenesulfonic acid monohydrate and piperidine was found to efficiently catalyze the cyclization between salicylaldehydes and alkynoic esters to give various coumarin derivatives in good yield and high selectivity. Mechanistic and kinetic data suggested that the conjugate addition between piperidine and alkynoic esters played a crucial role in the reaction mechanism.
| Original language | English |
|---|---|
| Article number | st-2022-u0084-c |
| Pages (from-to) | 1399-1404 |
| Number of pages | 6 |
| Journal | Synlett |
| Volume | 33 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - 1 Apr 2022 |
| Externally published | Yes |
Keywords
- alkynoic ester
- conjugate addition
- coumarin
- organocatalysis
- p -toluenesulfonic acid
- piperidine
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