Abstract
The present experiments were performed to investigate the differential involvement of the opioid receptor subtypes in the antinociception of intrathecal (IT) butorphanol compared to IT morphine. A single dose (26 nmol) of IT nor-binaltorphimine (nor-BNI), β-funaltrexamine (β-FNA), and naltrindole (NTI) demonstrated a significant attenuation in the overall antinociception of IT butorphanol (52 nmol) or IT morphine (26 nmol). However, IT butorphanol elicits thermal antinociceptive effect through K > δ ≤ μ, whereas morphine acts on μ > δ >> (K). These results indicate that the antinociceptive effect of both IT butorphanol and IT morphine are mediated through μ, δ, and (K) opioid receptors in different relative orders.
| Original language | English |
|---|---|
| Pages (from-to) | 723-727 |
| Number of pages | 5 |
| Journal | Pharmacology Biochemistry and Behavior |
| Volume | 59 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 1998 |
| Externally published | Yes |
Keywords
- Antinociceptive
- Butorphanol
- Intrathecal
- Morphine
Fingerprint
Dive into the research topics of 'Differential involvement of opioid receptors in intrathecal butorphanol- induced analgesia: Compared to morphine'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver