Diagnosis of murine typhus by serology in peninsular Malaysia: A case report where rickettsial illnesses, leptospirosis and dengue co-circulate

Yazli Yuhana; Ampai Tanganuchitcharnchai; Pimpan Sujariyakul; Piengchan Sonthayanon; Kesinee Chotivanich; Daniel H. Paris; Sasithon Pukrittayakamee; Stuart D. Blacksell; Borimas Hanboonkunupakarn

doi:10.3390/tropicalmed4010023

Diagnosis of murine typhus by serology in peninsular Malaysia: A case report where rickettsial illnesses, leptospirosis and dengue co-circulate

Yazli Yuhana
, Ampai Tanganuchitcharnchai
, Pimpan Sujariyakul
, Piengchan Sonthayanon
, Kesinee Chotivanich
, Daniel H. Paris
, Sasithon Pukrittayakamee
, Stuart D. Blacksell
, Borimas Hanboonkunupakarn

Faculty of Tropical Medicine, Mahidol University
Universiti Teknologi MARA
Mahidol University
Swiss Tropical and Public Health Institute, Parasite Chemotherapy
University of Basel
Churchill Hospital

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Murine typhus is a rarely diagnosed cause of acute febrile illness in Malaysia, and its true disease burden is unknown. We report a case of an acute murine typhus infection in a patient living in a small city in Peninsular Malaysia, presenting with fever, rash, and headache. Unresponsive to the initial empirical treatment for leptospirosis, he showed a rapid response to doxycycline when murine typhus was diagnosed later. This case highlights the importance of considering murine typhus as a diagnostic in cases of acute febrile illness in urban and sub-urban areas, such as that of in Peninsular Malaysia.

Original language	English
Journal	Tropical Medicine and Infectious Disease
Volume	4
Issue number	1
DOIs	https://doi.org/10.3390/tropicalmed4010023
Publication status	Published - 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Diagnosis
Malaysia
Murine typhus
Serology

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10.3390/tropicalmed4010023

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Yuhana, Y., Tanganuchitcharnchai, A., Sujariyakul, P., Sonthayanon, P., Chotivanich, K., Paris, D. H., Pukrittayakamee, S., Blacksell, S. D., & Hanboonkunupakarn, B. (2019). Diagnosis of murine typhus by serology in peninsular Malaysia: A case report where rickettsial illnesses, leptospirosis and dengue co-circulate. Tropical Medicine and Infectious Disease, 4(1). https://doi.org/10.3390/tropicalmed4010023

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title = "Diagnosis of murine typhus by serology in peninsular Malaysia: A case report where rickettsial illnesses, leptospirosis and dengue co-circulate",

abstract = "Murine typhus is a rarely diagnosed cause of acute febrile illness in Malaysia, and its true disease burden is unknown. We report a case of an acute murine typhus infection in a patient living in a small city in Peninsular Malaysia, presenting with fever, rash, and headache. Unresponsive to the initial empirical treatment for leptospirosis, he showed a rapid response to doxycycline when murine typhus was diagnosed later. This case highlights the importance of considering murine typhus as a diagnostic in cases of acute febrile illness in urban and sub-urban areas, such as that of in Peninsular Malaysia.",

keywords = "Diagnosis, Malaysia, Murine typhus, Serology",

author = "Yazli Yuhana and Ampai Tanganuchitcharnchai and Pimpan Sujariyakul and Piengchan Sonthayanon and Kesinee Chotivanich and Paris, \{Daniel H.\} and Sasithon Pukrittayakamee and Blacksell, \{Stuart D.\} and Borimas Hanboonkunupakarn",

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doi = "10.3390/tropicalmed4010023",

language = "English",

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journal = "Tropical Medicine and Infectious Disease",

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Yuhana, Y, Tanganuchitcharnchai, A, Sujariyakul, P, Sonthayanon, P , Chotivanich, K, Paris, DH, Pukrittayakamee, S, Blacksell, SD & Hanboonkunupakarn, B 2019, 'Diagnosis of murine typhus by serology in peninsular Malaysia: A case report where rickettsial illnesses, leptospirosis and dengue co-circulate', Tropical Medicine and Infectious Disease, vol. 4, no. 1. https://doi.org/10.3390/tropicalmed4010023

TY - JOUR

T1 - Diagnosis of murine typhus by serology in peninsular Malaysia

T2 - A case report where rickettsial illnesses, leptospirosis and dengue co-circulate

AU - Yuhana, Yazli

AU - Tanganuchitcharnchai, Ampai

AU - Sujariyakul, Pimpan

AU - Sonthayanon, Piengchan

AU - Chotivanich, Kesinee

AU - Paris, Daniel H.

AU - Pukrittayakamee, Sasithon

AU - Blacksell, Stuart D.

AU - Hanboonkunupakarn, Borimas

PY - 2019

Y1 - 2019

N2 - Murine typhus is a rarely diagnosed cause of acute febrile illness in Malaysia, and its true disease burden is unknown. We report a case of an acute murine typhus infection in a patient living in a small city in Peninsular Malaysia, presenting with fever, rash, and headache. Unresponsive to the initial empirical treatment for leptospirosis, he showed a rapid response to doxycycline when murine typhus was diagnosed later. This case highlights the importance of considering murine typhus as a diagnostic in cases of acute febrile illness in urban and sub-urban areas, such as that of in Peninsular Malaysia.

AB - Murine typhus is a rarely diagnosed cause of acute febrile illness in Malaysia, and its true disease burden is unknown. We report a case of an acute murine typhus infection in a patient living in a small city in Peninsular Malaysia, presenting with fever, rash, and headache. Unresponsive to the initial empirical treatment for leptospirosis, he showed a rapid response to doxycycline when murine typhus was diagnosed later. This case highlights the importance of considering murine typhus as a diagnostic in cases of acute febrile illness in urban and sub-urban areas, such as that of in Peninsular Malaysia.

KW - Diagnosis

KW - Malaysia

KW - Murine typhus

KW - Serology

UR - https://www.scopus.com/pages/publications/85075800736

U2 - 10.3390/tropicalmed4010023

DO - 10.3390/tropicalmed4010023

M3 - Article

AN - SCOPUS:85075800736

SN - 2414-6366

VL - 4

JO - Tropical Medicine and Infectious Disease

JF - Tropical Medicine and Infectious Disease

IS - 1

ER -

Diagnosis of murine typhus by serology in peninsular Malaysia: A case report where rickettsial illnesses, leptospirosis and dengue co-circulate

Abstract

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Keywords

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