Cytotoxicity against cholangiocarcinoma and HepG2 cell lines of lignan derivatives from Hernandia nymphaeifolia

Jittra Suthiwong; Jaroon Wandee; Siripit Pitchuanchom; Punchapat Sojikul; Veerapol Kukongviriyapan; Chavi Yenjai

doi:10.1007/s00044-018-2214-9

Cytotoxicity against cholangiocarcinoma and HepG2 cell lines of lignan derivatives from Hernandia nymphaeifolia

Jittra Suthiwong
, Jaroon Wandee
, Siripit Pitchuanchom
, Punchapat Sojikul
, Veerapol Kukongviriyapan
, Chavi Yenjai

Khon Kaen University
Faculty of Medicine, Khon Kaen University
Mahasarakham University
Mahidol University

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Twelve lignan derivatives were synthesized from deoxypodophyllotoxin isolated from Hernandia nymphaeifolia. Cytotoxicity evaluation against cholangiocarcinoma, KKU-100, and HepG2 cell lines showed that compounds 3, 9, 10, and 13 exhibited stronger cytotoxicity than the starting material, 1, with IC₅₀ ranging from 0.42 to 2.01 μM. Compound 10 displayed interesting activity by showing IC₅₀ values of 0.75 and 0.46 μM against KKU-100 and HepG2 cell lines, respectively. From these observation, 10 seems to be useful as a lead compound for the development of anticancer agents.

Original language	English
Pages (from-to)	2042-2049
Number of pages	8
Journal	Medicinal Chemistry Research
Volume	27
Issue number	8
DOIs	https://doi.org/10.1007/s00044-018-2214-9
Publication status	Published - 1 Aug 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Deoxypodophyllotoxin
HepG2
Hernandia nymphaeifolia
KKU-100

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10.1007/s00044-018-2214-9

Cite this

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title = "Cytotoxicity against cholangiocarcinoma and HepG2 cell lines of lignan derivatives from Hernandia nymphaeifolia",

abstract = "Twelve lignan derivatives were synthesized from deoxypodophyllotoxin isolated from Hernandia nymphaeifolia. Cytotoxicity evaluation against cholangiocarcinoma, KKU-100, and HepG2 cell lines showed that compounds 3, 9, 10, and 13 exhibited stronger cytotoxicity than the starting material, 1, with IC50 ranging from 0.42 to 2.01 μM. Compound 10 displayed interesting activity by showing IC50 values of 0.75 and 0.46 μM against KKU-100 and HepG2 cell lines, respectively. From these observation, 10 seems to be useful as a lead compound for the development of anticancer agents.",

keywords = "Deoxypodophyllotoxin, HepG2, Hernandia nymphaeifolia, KKU-100",

author = "Jittra Suthiwong and Jaroon Wandee and Siripit Pitchuanchom and Punchapat Sojikul and Veerapol Kukongviriyapan and Chavi Yenjai",

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doi = "10.1007/s00044-018-2214-9",

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TY - JOUR

T1 - Cytotoxicity against cholangiocarcinoma and HepG2 cell lines of lignan derivatives from Hernandia nymphaeifolia

AU - Suthiwong, Jittra

AU - Wandee, Jaroon

AU - Pitchuanchom, Siripit

AU - Sojikul, Punchapat

AU - Kukongviriyapan, Veerapol

AU - Yenjai, Chavi

PY - 2018/8/1

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N2 - Twelve lignan derivatives were synthesized from deoxypodophyllotoxin isolated from Hernandia nymphaeifolia. Cytotoxicity evaluation against cholangiocarcinoma, KKU-100, and HepG2 cell lines showed that compounds 3, 9, 10, and 13 exhibited stronger cytotoxicity than the starting material, 1, with IC50 ranging from 0.42 to 2.01 μM. Compound 10 displayed interesting activity by showing IC50 values of 0.75 and 0.46 μM against KKU-100 and HepG2 cell lines, respectively. From these observation, 10 seems to be useful as a lead compound for the development of anticancer agents.

AB - Twelve lignan derivatives were synthesized from deoxypodophyllotoxin isolated from Hernandia nymphaeifolia. Cytotoxicity evaluation against cholangiocarcinoma, KKU-100, and HepG2 cell lines showed that compounds 3, 9, 10, and 13 exhibited stronger cytotoxicity than the starting material, 1, with IC50 ranging from 0.42 to 2.01 μM. Compound 10 displayed interesting activity by showing IC50 values of 0.75 and 0.46 μM against KKU-100 and HepG2 cell lines, respectively. From these observation, 10 seems to be useful as a lead compound for the development of anticancer agents.

KW - Deoxypodophyllotoxin

KW - HepG2

KW - Hernandia nymphaeifolia

KW - KKU-100

UR - https://www.scopus.com/pages/publications/85049671953

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DO - 10.1007/s00044-018-2214-9

M3 - Article

AN - SCOPUS:85049671953

SN - 1054-2523

VL - 27

SP - 2042

EP - 2049

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 8

ER -

Cytotoxicity against cholangiocarcinoma and HepG2 cell lines of lignan derivatives from Hernandia nymphaeifolia

Abstract

UN SDGs

Keywords

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