Cytotoxic alkaloids from leaves and twigs of Dasymaschalon sootepense

Sakchai Hongthong; Chutima Kuhakarn; Vichai Reutrakul; Surawat Jariyawat; Pawinee Piyachaturawat; Narong Nuntasaen; Thaworn Jaipetch

doi:10.1177/1934578x1400900711

Cytotoxic alkaloids from leaves and twigs of Dasymaschalon sootepense

Sakchai Hongthong
, Chutima Kuhakarn
, Vichai Reutrakul
, Surawat Jariyawat
, Pawinee Piyachaturawat
, Narong Nuntasaen
, Thaworn Jaipetch

Mahidol University
Wildlife and Plant Conservation Department
Mahidol University

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the cytotoxic ethyl acetate fraction of the sequential methanol extract from the leaves and twigs of Dasymaschalon sootepense led to the isolation of a new 7-hydroxy aporphine alkaloid, 6a,7-dehydrodasymachaline (1) along with the five known compounds (-)-nordicentrine (2), dicentrinone (3), (-)-sinactine (4), aristolactam AII (5) and epiberberine (6). Their structures were elucidated by spectroscopic methods. This is the first report of alkaloids 1-2 and 5-6 from the genus Dasymaschalon. Compounds 1 and 5 showed cytotoxicity against a panel of cancer cell lines.

Original language	English
Pages (from-to)	929-932
Number of pages	4
Journal	Natural Product Communications
Volume	9
Issue number	7
DOIs	https://doi.org/10.1177/1934578x1400900711
Publication status	Published - Jul 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alkaloids
Aporphine alkaloids
Aristolactams
Cytotoxicity
Dasymaschalon sootepense

Access to Document

10.1177/1934578x1400900711

Cite this

@article{23e56015321a4376a1f3ac63dd85bfe7,

title = "Cytotoxic alkaloids from leaves and twigs of Dasymaschalon sootepense",

abstract = "Bioassay-guided fractionation of the cytotoxic ethyl acetate fraction of the sequential methanol extract from the leaves and twigs of Dasymaschalon sootepense led to the isolation of a new 7-hydroxy aporphine alkaloid, 6a,7-dehydrodasymachaline (1) along with the five known compounds (-)-nordicentrine (2), dicentrinone (3), (-)-sinactine (4), aristolactam AII (5) and epiberberine (6). Their structures were elucidated by spectroscopic methods. This is the first report of alkaloids 1-2 and 5-6 from the genus Dasymaschalon. Compounds 1 and 5 showed cytotoxicity against a panel of cancer cell lines.",

keywords = "Alkaloids, Aporphine alkaloids, Aristolactams, Cytotoxicity, Dasymaschalon sootepense",

author = "Sakchai Hongthong and Chutima Kuhakarn and Vichai Reutrakul and Surawat Jariyawat and Pawinee Piyachaturawat and Narong Nuntasaen and Thaworn Jaipetch",

year = "2014",

month = jul,

doi = "10.1177/1934578x1400900711",

language = "English",

volume = "9",

pages = "929--932",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "SAGE Publications Inc.",

number = "7",

}

TY - JOUR

T1 - Cytotoxic alkaloids from leaves and twigs of Dasymaschalon sootepense

AU - Hongthong, Sakchai

AU - Kuhakarn, Chutima

AU - Reutrakul, Vichai

AU - Jariyawat, Surawat

AU - Piyachaturawat, Pawinee

AU - Nuntasaen, Narong

AU - Jaipetch, Thaworn

PY - 2014/7

Y1 - 2014/7

N2 - Bioassay-guided fractionation of the cytotoxic ethyl acetate fraction of the sequential methanol extract from the leaves and twigs of Dasymaschalon sootepense led to the isolation of a new 7-hydroxy aporphine alkaloid, 6a,7-dehydrodasymachaline (1) along with the five known compounds (-)-nordicentrine (2), dicentrinone (3), (-)-sinactine (4), aristolactam AII (5) and epiberberine (6). Their structures were elucidated by spectroscopic methods. This is the first report of alkaloids 1-2 and 5-6 from the genus Dasymaschalon. Compounds 1 and 5 showed cytotoxicity against a panel of cancer cell lines.

AB - Bioassay-guided fractionation of the cytotoxic ethyl acetate fraction of the sequential methanol extract from the leaves and twigs of Dasymaschalon sootepense led to the isolation of a new 7-hydroxy aporphine alkaloid, 6a,7-dehydrodasymachaline (1) along with the five known compounds (-)-nordicentrine (2), dicentrinone (3), (-)-sinactine (4), aristolactam AII (5) and epiberberine (6). Their structures were elucidated by spectroscopic methods. This is the first report of alkaloids 1-2 and 5-6 from the genus Dasymaschalon. Compounds 1 and 5 showed cytotoxicity against a panel of cancer cell lines.

KW - Alkaloids

KW - Aporphine alkaloids

KW - Aristolactams

KW - Cytotoxicity

KW - Dasymaschalon sootepense

UR - https://www.scopus.com/pages/publications/84905110963

U2 - 10.1177/1934578x1400900711

DO - 10.1177/1934578x1400900711

M3 - Article

C2 - 25230495

AN - SCOPUS:84905110963

SN - 1934-578X

VL - 9

SP - 929

EP - 932

JO - Natural Product Communications

JF - Natural Product Communications

IS - 7

ER -

Cytotoxic alkaloids from leaves and twigs of Dasymaschalon sootepense

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this